Research and Reviews: A Journal of Pharmaceutical Science

Latest articles

• Published Subscription Review Article 14 Sep 2026

  AI Enabled Pharma Supply Chain Market

  By R. Ganesh

  Abstract: Pharmaceutical supply chains are changing because of artificial intelligence (AI). The pharmaceutical industry has always had to deal with uncertainty. From the start of research to the final delivery of medicines to patients, it faces scientific risks, government rules, and supply chain problems. In recent years, these challenges have gotten worse because there is more drug shortage, political issues are messing up transportation, and regulators are asking for more openness …

  Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article →

• Published Subscription Review Article 7 Aug 2026

  Acetaminophen: Current Understanding and Future Directions in Pharmacology

  By Chetan J. Girase, Prashant R. Wagh, Anand G. Gavale, Sujata S. Girase, Narendrasing R. Girase, Ghanshyam M. Chavan

  Abstract: In this review, acetaminophen is described as one of the most widely used analgesic and antipyretic medications worldwide due to its effectiveness and reduced gastrointestinal toxicity compared with traditional NSAIDs. Its precise mode of action is still unclear despite widespread therapeutic use. Acetaminophen has little peripheral anti-inflammatory effect and largely acts within the central nervous system, in contrast to NSAIDs, which mainly block peripheral cyclooxygenase (COX) enzymes and lower inflammation. …

  Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article →

• Published Subscription Review Article 21 Jun 2026

  Monoclonal antibodies in targeted cancer therapy advances, resistance mechanisms, and next-gen formats (Bispesifics, ADCs)

  By Aayush K. Ramraje, Bhupendra M. Mahale, Akshata M. Girase, Ghanshyam M. Chavan

  Abstract: Breast cancer is one of the leading causes of cancer-related morbidity and death worldwide, which emphasizes the need for more effective and focused treatment strategies. antibody-mediated drug delivery techniques. Specifically, antibody–drug conjugates (ADCs) have emerged as a potential approach that combines the specificity of monoclonal antibodies with the potent cytotoxicity of anticancer drugs. By selectively targeting tumor-associated antigens, ADCs enhance drug accumulation within cancer cells while minimizing systemic toxicity associated …

  Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 62–79 Read article →

• Published Subscription Original Research 4 Jun 2026

  Antimicrobial Resistance: A Growing Serious Threat for Global Public Health

  By Hemansi N. Patil, Akash S. Jain, Divakar R. Patil, Azam Z. Shaikh, Kanhaiyalal P. Patil, Hitendra S. Chaudhari, S. P. Pawar

  Abstract: Antibiotics, among the most significant discoveries of the 20th century, have prevented infectious diseases from claiming millions of lives. However, their widespread use and misuse have created strong selection pressure, enabling microbes to develop antimicrobial resistance (AMR) to many drugs. Over time, AMR has spread primarily through human-to-human contact, both within healthcare settings and in the community. It is driven by a complex interplay of healthcare and agricultural factors, including …

  Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 13–26 Read article →

• Published Subscription Original Research 3 May 2026

  Development and Characterization of a Solid Dispersion of an Anti-Diabetic Drug Using Pectin as a Natural Polymer

  By Atul Sahu, Pawan Kumar

  Abstract: Aim: The current study sought to improve the solubility and oral bioavailability of gliclazide by creating solid dispersions and oral dispersible tablets (ODTs) with enhanced physicochemical characteristics and maintained antidiabetic action. Methods: Preformulation studies were conducted to evaluate the physicochemical properties of gliclazide, including physical appearance, melting point, solubility, and partition coefficient. Solid dispersions were prepared using hydrophilic carriers-pectin and PVP K30, and subsequently characterized by Fourier Transform Infrared Spectroscopy …

  Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 01–12 Read article →

• Published Subscription Original Research 2 May 2026

  Hydrolysis-Driven Optimization of Hydroxypropyl Maize Starch for Improved Micro-Pellet Binding and Quick Solubility of Spirulina-Based Micro-Pellets

  By Ajay Giripunje, Srikanth Billa, Someshwarnath Pandey, Vishnudev Gupta, Bishwabhusana Palai

  Abstract: Acid hydrolysis is a well-established approach for modifying the physicochemical properties of polysaccharides & macromolecules including hydroxypropyl Maize starch (HPMS). In this study, the effect of varying concentrations of hydrochloric acid on the partial hydrolytic degradation of HPMS (Lycoat RS-780) was investigated at 85°C for 4 h, yielding polymers of different molecular weights. The Acid-mediated degradation effects on polymer characteristics were systematically assessed using capillary viscometry and gel permeation chromatography …

  Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 41–61 Read article →

• Published Subscription Review Article 22 Apr 2026

  Plant-Derived Antimicrobials as Next-Generation Solutions to Multidrug Resistance

  By Rohit kumar, Shraddha Pareek, Tanya Sharma, Kamalesh Mistry

  Abstract: The steady rise of multidrug-resistant (MDR) pathogens is reshaping how clinicians, researchers, and policymakers think about infection control. When bacteria acquire the ability to survive exposure to three or more antibiotic classes at once—whether through efflux pumps, enzyme-mediated drug destruction, target modifications, or reduced membrane permeability—treatment options narrow dramatically, hospital stays lengthen, and mortality climbs. Conventional pharmaceutical pipelines have struggled to keep pace with this biological arms race, pushing the …

  Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 27–40 Read article →

• Published Subscription Review Article 31 Mar 2026

  Drug Resistance in Targeted Cancer Treatment: Clinical Difficulties, Molecular Mechanisms, and Emerging Strategies

  By Bharath B., Darshan G., Hamsa Priya M.

  Abstract: Targeted cancer therapy, which selectively inhibits the molecular mechanisms responsible for tumor growth and development, has revolutionized modern oncology. Targeted therapies have lower systemic toxicity and better therapeutic efficacy when compared to traditional chemotherapy. However, the emergence of medication resistance often limits the long-term efficacy of these treatments, ultimately resulting in treatment failure and disease progression. Drug resistance develops through a number of intricate biological processes and can be innate …

  Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 130–138 Read article →

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