Research and Reviews: A Journal of Pharmaceutical Science
Volume 15, Issue 2 (2024)
Table of contents
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Factors Affecting Shear Stress on Tablet Hardness and Disintegration
Abstract: The quality and effectiveness of pharmaceutical tablets depend heavily on several factors influencing shear stress on tablet hardness and disintegration. These factors include formulation composition, wherein the selection and concentration of excipients and active ingredients affect how the tablet material responds to shear stress. Additionally, the compression force, speed, and duration during tablet compression are critical, impacting tablet hardness and disintegration properties. Tablet geometry and design, along with tablet press …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 1–19 Read article
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AI Powered Invention in Pharmaceuticals Boosting Innovation
Abstract: Artificial intelligence has the potential to transform the drug discovery process, making the process more efficient, accurate and faster. But the success of artificial intelligence depends on the availability of good data, resolution of ethical issues, and awareness of the limitations of artificial intelligencebased methods. The present article examined the benefits, challenges, and shortcomings of skills in the workplace and suggested strategies and practical actions to overcome current challenges. Data …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 102–107 Read article
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Method of Making Organic Insecticides, Hair Color and Lip Lotion by Utilizing Natural Constituents
Abstract: In today's chemical world, a return to nature has become the need. Since chemicals are now used in almost everything, they have become a necessary component of modern life. For this reason, avoiding the use of chemicals and using products made from natural materials is beneficial for the environment, human life and society in every aspect. In the present paper mainly three products were made. First product was organic plant …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 108–113 Read article
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Phytopharmacognostical Study and Development & Assessment of Topical Herbal Ointment from Leaves of Calotropis gigantea
Abstract: Joint pain is a common problem that affects people all over the world and calls for efficient treatment solutions. The present study investigated the creation of a topical formulation for the treatment of joint pain that uses an extract from the leaves of Calotropis gigantea. C. gigantea is sometimes referred to as huge milk weed and aak leaves. It is a member of the Apocynaceae family. This versatile plant has …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 114–120 Read article
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UV Method of Development and Validation of Olaparib
Abstract: An analytical method must be developed and validated in the discovery, development, and production of pharmaceuticals to ensure the identification, purity, potency, and performance of drug commodities. Quality control laboratories use official test protocols that emerge from the processes. A simple ultraviolet spectrophotometric approach was designed and validated using various characteristics, including linearity. Precision, reproducibility, accuracy, robustness, ruggedness, limit of detection, and limit of quantification are among the measuring criteria. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 20–27 Read article
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Implementing Quality by Design (QbD): Strategies, Challenges, and Best Practices across Industries
Abstract: The present comprehensive review investigated the dynamic landscape of quality standards within the pharmaceutical sector, with a primary focus on the implementation and impact of Quality by Design principles. It illuminated the multifaceted challenges encountered by pharmaceutical companies in upholding stringent quality standards amidst evolving regulatory requirements and complex manufacturing processes. By embracing Quality by Design principles, the industry aims to foster a proactive and systematic approach to product development …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 28–36 Read article
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Estimation of Alogliptin and Dapagliflozin in Synthetic Mixture by RP-HPLC Method
Abstract: The primary objective of the proposed research was to develop and validate analytical methods for the simultaneous quantification of Alogliptin and Dapagliflozin in a synthetic mixture. Alogliptin and Dapagliflozin are medications used for managing diabetes, with Alogliptin inhibiting the enzyme Dipeptidyl peptidase-4 and Dapagliflozin belonging to the class of sodium-glucose cotransporter 2 inhibitors. High-performance liquid chromatography method development was conducted using a C18 column (250 mmX4.6 mm, 5 μm particle …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 37–46 Read article
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An Effective & Novel Approach as Gastro-retentive Drug Delivery Systems
Abstract: Researcher’s curiosity about gastro-retentive drug delivery system increased so high in recent years because of its excellent drug releasing properties to the target site. The delivery system's residence time in the stomach can be extended with the usage of gastro-retentive drug delivery system by using a number of natural and synthetic polymers such as guar gum, hydoxy propyl methyl cellulose which can be used to improve the bioavailability of a …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 47–54 Read article
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Quantitative Structure-activity Relationship in Computer-aided Drug Design: A Review
Abstract: Quantitative Structure-Activity Relationship stands at the forefront of Computer-Aided Drug Design, providing a systematic framework for understanding the relationship between the chemical structure of molecules and their biological activity. The present review delves into the multifaceted realm of quantitative structure-activity relationship methodologies within the landscape of drug discovery. Through an exploration of diverse quantitative structure-activity relationship models, molecular descriptors, validation techniques, and recent advancements, the present article aims to elucidate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 55–63 Read article
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Targeting Dystrophin Restoration and Neuroprotection in Duchenne Muscular Dystrophy: Insights from Withania somnifera
Abstract: Duchenne muscular dystrophy is a genetic disorder. This disease affects men more common than women. Main objective of the present study was to identify the naturally active phytocompounds from Withania somnifera (Ashwagandha). Ashwagandha has a great value in the field of Ayurveda and Indian medicine and is used for treating muscular and neurological disorders. Toxicity prediction, molecular docking, statistical information, drug illness prediction, and Absorption, distribution, metabolism, excretion, and toxicity …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 64–84 Read article
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Advancement and Limitations of Raman Spectroscopy: A Review
Abstract: The present review provided an overview of advances and limitations in Raman spectroscopy— a powerful analytical tool widely used across scientific disciplines. Instrumental advances, including the development of lasers, detectors, and optics, have increased the scope of Raman spectroscopy. These advances have expanded its applications in fields such as information science and biology. The integration of Raman spectroscopy with additional technologies such as microscopy and artificial intelligence further expands analytical …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 85–97 Read article
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Comprehensive Analysis of MRSA Peptides Via Maldi
Abstract: The present study employed Matrix-Assisted Laser Desorption/Ionization Time-of-Flight mass spectrometry to analyze methicillin-resistant Staphylococcus aureus peptides, focusing on various parameters associated with mass-to-charge (m/z) values. Through systematic data collection and analysis, including time, intensity, signal-to-noise ratios, quality factors, resolutions, areas under the peaks, relative intensities, full widths at half maximum, Chi-squared values, and background peaks, comprehensive insights into the spectral characteristics of methicillin-resistant Staphylococcus aureus peptides were obtained. Methicillin-resistant Staphylococcus …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 98–101 Read article