Research and Reviews: A Journal of Pharmaceutical Science
Volume 11, Issue 3 (2020)
Published
Table of contents
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Dipeptidyl peptidase-IV (DPP-IV) Inhibitors – a promising oral anti-diabetic drug
Abstract: Dipeptidyl-peptidase IV (DPP-4) inhibitors inhibit the degradation of the incretins i.e glucagon-like peptide1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). Incretins augment the insulin release by a blood glucose-dependent mechanism. Generally DPP-IV enzyme is responsible for inactivating incretins and this enzyme inhibition will prolong and enhance the activity of GLP-1 and GIP. DPP-IV inhibitors increase post prandial insulin secretion, decreases glucagon secretion and seems to have beneficial effect on cardiovascular system, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 3, 2020 · pp. 1–6 Read article
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A Review and Update on Pharm.D in India
Abstract: The Pharm.D program in India was introduced in 2008 by Pharmacy Council of India (PCI) under the legal framework of Pharm.D Regulation 2008. As approved by the Government of India, Ministry of Health , letter No.V.13013/1/2007-PMS, dated the 13th March, 2008 and notified by the Pharmacy Council of India. Pharm.D (Doctor of Pharmacy) meaning in New Latin Pharmaciae Doctor is a professional doctorate degree in pharmacy. Pharm D is first …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 3, 2020 · pp. 14–18 Read article
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Quantitative Determination of Isomeric Components of essential oils by RP-HPLC-PDA in multi-herbal tablets
Abstract: Essential oils are lipophilic and highly volatile secondary plant metabolites, principally mono- and sesquiterpenes. The widespread usage and applications in biopharmaceutics and cosmoceutics of these components drives their quality assessments criteria to be established. Gas chromatography is one of the predominantly used technique for analyzing volatile oils. Although Gas Chromatography employs estimation designs operated at elevated temperatures leading for plausible structural alterations of thermo labile compounds. Hence, a novel gradient …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 3, 2020 · pp. 19–28 Read article
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Design, Synthesis and Pharmacological Evaluation of Pyrazoline Substituted Benzimidazole Derivatives as Antibacterial and Antifungal Agents
Abstract: Background: Benzimidazoles are important heterocyclic compounds possessing a variety of biological activities such as anticancer, antioxidant, antiinflammatory, analgesic, anti-viral, anti-bacterial, anti-fungal and hypoglycemic activities. Pyrazolines are used as antitumor, immunosuppressive, antibacterial and anti tubercular agents. Aim : The present research focused on incorporating pyrazoline nucleus into benzimidazole nucleus to form a potent antibacterial and antifungal agent. Method: The in silico design of novel pyrazoline substituted benzimidazole derivatives was done using …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 3, 2020 · pp. 29–41 Read article
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A Comparative Pharmaceutical Analysis on Different Extracts of Areca Catechu by Maceration & Percolation with Areca Tea
Abstract: This study evaluates the dissimilarity in phytochemical and Quality control analysis of different extract of Areca catechu by maceration and percolation and from Homoeopathic trituration along with Areca tea of Nivedan Nimpe. Homoeopathic pharmacopeia of India states that Areca catechu can be prepared homoeopathically by trituration process in 7th[1 & 9th volume but Areca mother tincture is available in the market [2]. Through this study, authors have tried to investigate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 3, 2020 · pp. 42–47 Read article
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Synthesis and Anti - Inflammatory Activity of A Novel Series of Quinoxaline2, 3-Dione Derivatives
Abstract: Aim: The aim of the present study is to synthesis and screening the anti-inflammatory effect of novel series of quinoxaline 2, 3Dione derivatives containing a 4-thiazolidinone (T1-T5) nucleus. Method: Thesynthesis of thiazolidinones by reacting N-substituted arylidene/heteroarylidene Quinoxaline 2, 3-dione with thioglycollic acid in the presence of dry benzene. All the title compounds were tested for their anti-inflammatory activity of the synthesized compounds was evaluated by Carrangeenan induced paw edema method …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 3, 2020 · pp. 7–13 Read article