Research and Reviews: A Journal of Pharmaceutical Science
Volume 8, Issue 2 (2017)
Published
Table of contents
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Quantitative Structure Activity Relationship Studies of Some New 4-Thiazolidinone Derivatives as Antimicrobial Agents
Abstract: In the present study, quantitative structure activity relationship (QSAR) studies have beenperformed on series of 24 compounds of 4-thiazolidinone derivatives with antimicrobialactivity using Chemoffice version 8.0 software. The QSAR models have been developed byusing multiple linear regressions in order to identify descriptors, which are actually focusingtowards the biological activity. Leave one out (LOO) method was employed in crossvalidation analysis to validate the developed model. The best predictive QSAR model derived,had …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 1–3 Read article
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A Comprehensive Review on Buccal Drug Delivery System
Abstract: Buccal delivery involves the running of the desired drug through the buccal mucosal membrane lining of the oral cavity. The buccal region of the oral cavity is a striking target for administration of the drug of choice because it offers some discrete advantages over all other routes. However, the mucosal lining of the oral cavity drugs which undergo rigorous firstpass metabolism, for those drugs, buccal route are excellent. Buccal drug …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 20–32 Read article
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Formulation, Optimization and Evaluation of Flurbiprofen Liposomal Gel
Abstract: The present study deals with effect of various combinations of lecithin, cholesterol, chloroform-methanol and tween-80 on liposomes of flurbiprofen. Optimization of the flurbiprofen liposomes by Design Expert software was done. Vesicle size, drug content, SEM and entrapment efficiency were evaluated. Flurbiprofen gel with optimized liposome using Carbopol 934 as gelling agents, were formulated. pH, spreadability and drug content in the gel were evaluated. Results of skin irritation study showed that …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 33–42 Read article
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3D QSAR Studies of 2,3-Disubstituted Quinazolin Phenyl Acetic Acid Derivatives as Antimicrobial Agents
Abstract: Quantitative structure activity relationship (QSAR) studies have been performed on series of31 compounds of 2,3-disubstituted quinazolin phenyl acetic acid derivatives withantimicrobial activity using Chemoffice version 8.0 software. The QSAR models have beendeveloped by using multiple linear regressions in order to identify descriptors, which areactually focusing towards the biological activity. Leave one out (LOO) method was employedin cross validation analysis to validate the developed model. The best predictive QSAR modelderived, had …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 4–7 Read article
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Two New, Useful and Facile Stability-Indicating UV Spectrophotometric Methods for the Determination of Rosiglitazone in Pharmaceuticals
Abstract: Rosiglitazone (ROS) is an antidiabetic drug belonging to the thiozolidine class. Two simple, rapid, sensitive, accurate and reproducible UV-spectrophotometric methods were developed and subsequently validated for the determination of ROS in bulk and tablet form. The methods are based on the measurement of the absorbance of the drug solution either in 0.1 M NaOH (NaOH method) or in 0.1 M HCl (HCl method) at 316 nm in both instances. The …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 8–19 Read article