Research and Reviews: A Journal of Pharmaceutical Science
Volume 8, Issue 1 (2017)
Published
Table of contents
-
Development and Validation of a New Stability-Indicating HPLC Method for the Determination of Rosiglitazone in Tablets
Abstract: Rosiglitazone (ROS) is an antidiabetic drug belonging to the thiazolidine class. A new stability-indicating high-performance chromatographic (HPLC) method was developed for the determination of ROS in pharmaceuticals, and validated for its suitability following the ICH guidelines. Chromatography was performed on a Chromatopack (250×4.6 mm; 5 µm particle size) column using phosphate buffer of pH 3.2 and methanol (70:30 v/v) as mobile phase pumped at a flow rate of 1 ml …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 1, 2017 · pp. 1–9 Read article
-
Autism Spectrum Disorder
Abstract: Autistic Spectrum Disorder (ASD) is a neurological and developmental disorder that begins early in childhood and last throughout person’s life. It is called spectrum disorder because people with ASD can have a range of symptoms like disabilities in communication, restricted interest and repetitive behavior. Causes: Autism is highly heritable, researchers suspect both environmental and genetic factors as causes. In rare cases, autism is strongly associated with agents that cause birth …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 1, 2017 · pp. 10–16 Read article
-
Development and Validation of HPTLC Methods for Estimation of Trimebutine Maleate in Pharmaceutical Formulation
Abstract: A simple and rapid high-performance thin-layer chromatographic (HPTLC) method was developed and validated for quantitative determination of trimebutine maleate in single dose formulation. Trimebutine maleate was chromatographed on silica gel 60 F 254 TLC plate using methanol–toluene (8:2 v/v) as mobile phase. The plates were developed to a distance of 8 cm at ambient temperature. Trimebutine maleate was quantified by densitometric analysis at 271 nm. The method was found to …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 1, 2017 · pp. 17–22 Read article
-
Current Updates on Risk Factors of Hepatocellular Carcinoma
Abstract: Hepatocellular carcinoma (HCC) has a rising incidence in India frequently due to high prevalence of viral hepatitis, alcoholism, aflatoxin and its complications. HCC may affect more than 100 out of 100,000 people who live in some parts of Asia and Africa. Whatever that affects your probability of getting an ailment is called risk factor. Several risk factors, such as sex and place where you were born, are out of your …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 1, 2017 · pp. 23–31 Read article
-
Modified Nucleosides “(ProTide)†as Potential Anti-HCV Therapeutics
Abstract: Hepatitis C virus (HCV) is among the most common causes of cirrhosis and chronic liver disease worldwide. As a result, many researchers are interested in designing and synthesis of a clinical treatment for HCV. Nucleoside monophosphates and monophosphonates play such an important role for treatments of incurable diseases such as hepatitis. For example, 2'-C-methyladenosine and 2'-C-methyl guanosine have shown activities against HCV in the replicon assay as well as against …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 1, 2017 · pp. 32–39 Read article