Research & Reviews: A Journal of Drug Formulation, Development and Production

Latest articles

• Published Subscription Review Article 3 Jun 2026

  Pharmacokinetics of Levothyroxine and Factors Influencing Its Therapeutic Efficacy in Hypothyroidism: A Comprehensive Review

  By Mohd. Farhan, Nalini Kanta Sahoo, Alex Martin, Rajesh Nath, Asad Jamal Ansari, Ebadurrahman, Saurabh Kumar Chauhan

  Abstract: Levothyroxine (LT4) remains the standard therapy for hypothyroidism due to its effectiveness in restoring normal thyroid hormone levels and improving physiological functions. However, its pharmacokinetic profile exhibits considerable variability, which may influence therapeutic outcomes in clinical practice. This review aims to comprehensively evaluate the pharmacokinetics of levothyroxine, including its absorption, distribution, metabolism, and elimination, along with factors affecting its therapeutic efficacy. A structured literature search was conducted using electronic databases, …

  Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 Read article →

• Published Subscription Original Research 3 Jun 2026

  Formulation and Evaluation of a Polyherbal Lip Scrub Containing Beetroot, Licorice, and Aloe Vera

  By Sayli S. Saw, Deepak Mourya, Shubham Singh, Sanjesh Rathi

  Abstract: The current research is aimed at developing and assessing a polyherbal lip scrub which contains beetroot extract, licorice extract and aloe vera gel to enhance better exfoliation, nutritional and depigmentation. The fusion method was applied to the herbal extract formulations by varying systematically the concentration of the herbal extracts to develop the 4 formulations (F1-F4) each of 15 g. These prepared formulations were tested on their important physicochemical and functional …

  Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 Read article →

• Published Subscription Review Article 10 May 2026

  A Review on the Regulatory Study for Implementation of Schedule-M Amendments in Pharmaceutical Industries in India

  By Sahil Sanjay Varpe, Aishwarya Bhandare, Atish Velhal, Prakash Jadhav

  Abstract: A major regulatory change in pharmaceutical manufacturing industry in India is the introduction of the updated Schedule M (2023–2024). The aims to compliance the country's Good Manufacturing Practices (GMP) with international quality standards. The review evaluates the Schedule M amendments implementation strategies, industrial impact and regulatory relevance. Legislative texts, official notices, WHO GMP reports, ICH guidelines, guidance documents of CDSCO and peer-reviewed literature were all explored as part of the …

  Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article →

• Published Subscription Review Article 23 Apr 2026

  Comprehensive Evaluation of Quercetin from Bauhinia purpurea for Its Anti-Acne and Anti-Inflammatory Potential, Including Advances in Quercetin-Loaded Nanogel Formulation

  By Astha Bhandari, Kamlesh Mistry, Tanya Sharma

  Abstract: Acne vulgaris is among the most prevalent chronic inflammatory dermatoses in clinical dermatology, afflicting a substantial proportion of the global adolescent and adult population. Conventional pharmacotherapies — including topical retinoids, benzoyl peroxide, and systemic antibiotics — remain the therapeutic mainstay; however, their long-term utility is progressively undermined by adverse cutaneous reactions, systemic toxicity, and the rising prevalence of antibiotic-resistant Cutibacterium acnes strains. These limitations have intensified scientific interest in plant-derived …

  Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article →

• Published Subscription Original Research 23 Apr 2026

  Formulation and Evaluation of a Natural Excipients-Based Diclofenac Sodium Topical Ointment

  By Meet Rathod, Dhruv Patel, Apurba Chakrabarty, Nilesh Prakash Badgujar

  Abstract: The present study reports the formulation and evaluation of a diclofenac sodium topical ointment incorporating natural excipients to improve skin compatibility and formulation sustainability. Conventional topical non-steroidal anti-inflammatory drug (NSAID) formulations frequently rely on synthetic excipients that may cause dermal irritation and pose environmental concerns. To address these limitations, a 1% w/w diclofenac sodium ointment was developed using aloe vera gel, glycerin, xanthan gum, peppermint oil, vitamin E, and isopropyl …

  Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article →

• Published Subscription Review Article 23 Apr 2026

  Bioenhancer to Boost Herbal Drug Efficacy

  By Jayesh B. Patil, Hitendra S. Chaudhari, Roshan M. Chaudhari, Akash S. Jain, Divakar R. Patil, Sunil P. Pawar

  Abstract: Bioenhancers are natural substances that significantly improve the absorption, bioavailability, and therapeutic efficacy of drugs when co-administered, without showing notable pharmacological activity of their own. In herbal medicine, the concept of bioenhancement has received growing attention as many phytoconstituents exhibit low oral bioavailability due to poor solubility, limited permeability, and extensive first-pass metabolism. The traditional Ayurvedic system first introduced this concept through the discovery of Piperine, the active alkaloid from …

  Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article →

• Published Subscription Review Article 31 Jan 2026

  Outward Material Storage Area and Dispensing Activity for Packaging Material Area

  By Shraddha Dadaso Kharat, Jadhav Shweta Rajendra, Mane Snehal Sandesh

  Abstract: Efficient management of outward material storage and packaging material dispensing is essential for maintaining product quality, regulatory compliance, and streamlined operations in manufacturing industries. This review examines the principles, practices, and challenges associated with the design, organization, and control of outward material storage areas, with a specific focus on packaging material handling. Key aspects discussed include layout optimization, material segregation, environmental controls, documentation practices, and adherence to Good Manufacturing Practices …

  Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 27–32 Read article →

• Published Subscription Review Article 17 Jan 2026

  Stability-Indicating Rp-Hplc Development and Validation for the Estimation of Lercanidipine Hydrochloride Content in Tablet Dosage Form

  By Ratnakar Tripathi, Bhushan Korde, Sunil Kumar Shah, B.K. Dubey, Deepak Kumar Basedia

  Abstract: A sensitive, stability-revealing, and easy reverse-phase high-performance liquid chromatographic (RP-HPLC) technique was developed and rationalized to be in a position to determine Lercanidipine hydrochloride in ingested dosing preparations. It was separated by chromatography on a C 18 column using a mobile phase containing 10 mM potassium dihydrogen phosphate buffer and methanol (20:80, v/v; pH 4.0) at a flow rate of 1.0 mL/min and UV detected at 258 nm. The retention …

  Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 17–26 Read article →

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