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Research & Reviews: A Journal of Drug Formulation, Development and Production Original Research

Formulation and Evaluation of Luliconazole Loaded Microemulgel

  1. Shendre Kamalesh Vishnu Department of Pharmaceutics, P.S.G.V.P. Mandal’s College of Pharmacy, Shahada
  2. Dhankani Mansi Amitkumar Department of Pharmaceutics, P.S.G.V.P. Mandal’s College of Pharmacy, Shahada
  3. Dhankani Amitkumar Rajkumar Department of Quality Assurance, P.S.G.V.P. Mandal’s College of Pharmacy, Shahada
  4. Pawar Sunil Pandit Department of Pharmacognosy, P.S.G.V.P. Mandal’s College of Pharmacy, Shahada

Abstract

The aim of present study is to formulate and evaluate Luliconazole Microemulgel. Microemulgel is combination of microemulsion and gel. The problem associated with delivery of hydrophobic drug can be solved by incorporating drug in microemulsion and then microemulsion is combined with gel to form microemulgel. Solubility of Luliconazole is determined and it was found to be soluble in ethanol, methanol, chloroform, while it was insoluble in water. The melting point of Luliconazole was determined and found to be within the range of 149°C to 151°C. Further confirmation of drug authenticity and purity was done by UV Spectroscopy where maximum absorption peak found at 297 nm. FTIR study shown that drug and excipients are compatible with each other. formulation batches was prepared and optimized on the basis of evaluating parameters such as Physical Appearance, pH, Spreadability, Extrudability, Rheological study, drug content, zeta potential, In Vitro drug release. The Formulation batch F4 shown highest in vitro cumulative drug release 90.86% and drug content 97.08%.

Keywords

References (10)

  1. Kuller R. Saini S, N., Rana, A. C. Emulgel: A surrogate approach for topical used hydrophobic drugs, International Journal of Pharma and Bio sciences, 2011; 13):117-128.
  2. Michael S, Kenneth A. Skin Structure, Pharmaceuticals, Cosmetics, and the Efficacy of Topically Applied Agents. Dermatologic, Cosmetic, and Cosmetic Development, Therapeutic and Novel Approaches. Informa Healthcare USA, Inc, 2008; 01(01):01-10.
  3. Ueda C, Shah V, Derdzinski K, Ewing G, Flynn G, Maibach H, Marques M, Rytting H, Shaw S, Thakker K, Yacobi A. Topical and Transdermal Drug Products. United states Pharmacopeia, 2009; 35(03):750-764.
  4. Bhowmik D, Gopinath H, Kumar P, Duraivel S, Kumar S. Recent advances in Novel Topical Drug Delivery System. The Pharma innovation, 2012; 01(09):12 31
  5. Shah A, Kamdar K, Shah R, Keraliya R, Emulgel: A Topical Preparation for Hydrophobic Drugs, Pharma Tech Medica, 2013;02(05):370-376.
  6. P Kushwah, P K Sharma, S S Koka, A Gupta, R Sharma, G N Darwhekar Microemulgel: A Novel Approach For Topical Drug Delivery, Journal of Applied Pharmaceutical Research Volume 9, Issue 3, Year of Publication 2021, Page 14 – 20.
  7. Sumeet Patidar, Gaurav Kant Saraog Latest Developments in Microemulgels: A Novel Approach in Drug Delivery Systems. International Journal of Newgen Research in Pharmacy & Healthcare Volume-3, Issue-1, June 2025
  8. Panchaxari Mallappa Dandagi, Pratibha Pandey, Anand Panchakshari Gadad, Vinayak Shivamurthy Mastiholimath; Formulation and Evaluation of Microemulsion Based Luliconazole Gel for Topical Delivery; Indian Journal of Pharmaceutical Education and Research | Vol 54 | Issue 2 | Apr-Jun, 2020.
  9. Shilpi Rathore, Mrs. Sunita Patidar, Mrs. Apurva Pagare; Microemulgel: A Novel Vehicle for Antimicrobial Drugs; International Journal of Pharmaceutics and Drug Research; 2023; 11(S), 177-188.
  10. Ms. Pratiksha S Suryawanshi, Dr.Rajashree S. Chavan, Mr.Nilesh R Bhosale, Dr.Prashant H Khade, Ms.Aishwarya B Kashid. Review On Microemulsion Based Gel On Topical Drug Delivery System. 2024 IJRTI | Volume 9, Issue 12 December 2024 | ISSN: 2456-3315.
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