Research & Reviews: A Journal of Drug Formulation, Development and Production
Volume 8, Issue 1 (2023)
Published
Table of contents
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Application of Prodrug to Improve Skin Permeability: A Review
Abstract: Administration of drug via skin has some limitations such as skin barrier, solubility of drug and partition coefficient etc. Stratum corneum which is an outer skin layer, acts as a barrier to the skin. Thus, prodrug has some applications to improve skin permeability. Prodrugs are defined as the compounds which are initially inactive but covert into their active form when reacted with several chemicals or enzymes at particular active site …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 1, 2023 · pp. 1–11 Read article
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Formulation Development of Meloxicam Loaded Transdermal Patches and Their Evaluation
Abstract: The current studies aim the Formulation and development of transdermal patches of Meloxicam. Meloxicam is a Non- Steroidal Anti-inflammatory Drug. Transdermal patches show better patient compliance over conventional dosage forms because of their longer time of operation resulting in a reduction in less frequent dosing. Six batches of transdermal patches were prepared using different concentrations of hydroxyl propyl methyl cellulose, ethyl cellulose, and polyvinyl pyrrolidone to increase the physical properties …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 1, 2023 · pp. 12–22 Read article
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Review on Impurity Profiling Techniques and their Importance in Pharmaceutical Field
Abstract: Impurity profiling is the process of detection, evaluation and determination of impurities present in any drug (bulk or formulated) or biological product. Impurity profiling comprises elucidation, structure, identification and quantitative determination of impurities and degradation products in bulk drug materials and pharmaceutical formulations done by LC-MS, GC-MS and CE-MS. The present review discusses many facts related to the analytical methods of development for impurity profiling of drugs. Impurity profiling is …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 1, 2023 · pp. 23–32 Read article
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Spectroscopic and Chromatographic Methods for Estimation of Voriconazole in Bulk and Pharmaceutical Dosage Forms
Abstract: Rapid, accurate and precise methods have been developed for estimation of voriconazole in bulk and pharmaceutical dosage forms using Ultraviolet (UV) spectroscopy and reverse phase high performance chromatography (RP-HPLC). The λmax selected in UV spectroscopy method was 255 nm and the calibration curve was linear in the concentration range of 2-50 µg/mL with correlation coefficient (r2)>0.99. In RP-HPLC method, the separation was carried out on Kromasil C18 (250 x 4.6mm, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 1, 2023 · pp. 33–39 Read article
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Development Aspects, Physiochemical Characteristics, Pharmaceutical Requirements and Different Manufacturing Procedures for Dry Powder Inhalation Formulations
Abstract: Dry Powder Inhalation (DPI) products are combination of pharmacologic activity and pharmaceutical properties including procedure used to manufacture. Desirable performance features of DPI are physical and chemical stability, ease of handling, accurate and reproducible delivery to the target organ and availability of drug at the site of action. The physical stability of DPI is of utmost importance as it results in ultimate deposition of drug through various dispersion mechanisms into …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 1, 2023 · pp. 40–48 Read article