STM Journals Peer-reviewed research from Consortium e-Learning Network

Research & Reviews: A Journal of Drug Formulation, Development and Production Original Research

Formulation and Evaluation of a Polyherbal Lip Scrub Containing Beetroot, Licorice, and Aloe Vera

  1. Sayli S. Saw Department of Pharmacy, School of Pharmacy, Rai University, Ahmedabad
  2. Deepak Mourya Department of Pharmacy, School of Pharmacy, Rai University, Ahmedabad
  3. Shubham Singh Department of Pharmaceutics, School of Pharmacy, Rai University, Ahmedabad
  4. Sanjesh Rathi Department of Pharmaceutics, School of Pharmacy, Rai University, Ahmedabad

Abstract

The current research is aimed at developing and assessing a polyherbal lip scrub which contains beetroot extract, licorice extract and aloe vera gel to enhance better exfoliation, nutritional and depigmentation. The fusion method was applied to the herbal extract formulations by varying systematically the concentration of the herbal extracts to develop the 4 formulations (F1-F4) each of 15 g. These prepared formulations were tested on their important physicochemical and functional properties such as pH, spreadability, viscosity, homogeneity, washability, skin irritation and stability. All the formulations showed acceptable properties with a pH range of 4.05 to 4.32, which were suitable to use in lips. The spreadability was between 4.5 and 5.6 cm with formulation F2 having the highest value (5.6 cm), which means that the formulation is easy to apply. The range present was 4200-6200 cP with F2 being in optimal position of balance between firmness and spreadability. Good homogeneity of all batches, uniform distribution of exfoliating particles, no phase separation. There was no irritation, redness, or inflammation at the time of the skin compatibility study. The stability studies were realized under the long-term and under the accelerated conditions the studies have shown no significant changes in the physicochemical properties. Of all the formulations, F2 was found as the optimized batch, based on its balanced mix, good spreadability, sufficient viscosity and stability in general. These results indicate that the designed polyherbal lip scrub is a stable and well-working formulation that could provide a gentle exfoliation effect as well as an increased lip care option making it a promising natural substitute of conventional products.

Keywords

References (14)

  1. Swati Saxena, Arvind Kumar Pankaj, Kanchan Bisht, Anita Rani, Jyoti Chopra, Sachin Panwar, et al. Histological changes of lower lip from its cutaneous to mucosa region in males. Asian Journal of Medical Sciences. 2022;13(11):284-289. doi:10.3126/ajms.v13i11.44371
  2. Cho YT, Su H, Wu CY, Jeng J, Lee CW, Wu DC, et al. The study of distribution of ingested terbinafine on skin with ambient ionization tandem mass spectrometry. Journal of Food and Drug Analysis. 2022;30(2):303-315. doi:10.38212/2224-6614.3413
  3. Lugović-Mihić L, Špiljak B, Blagec T, Delaš Aždajić M, Franceschi N, Gašić A, et al. Factors Participating in the Occurrence of Inflammation of the Lips (Cheilitis) and Perioral Skin. Cosmetics. 2023;10(1):9. doi:10.3390/cosmetics10010009
  4. Ortiz-Contreras J, Navarro-Cáceres P, Kasprzak J, Fonseca GM. Study of Lip Conditions Associated with Lip Print Patterns: A New Perspective on Cheiloscopy. International Journal of Morphology. 2024;42(3):567-576. doi:10.4067/s0717-95022024000300567
  5. Sutthiboonyapan P, Sriratanasak N, Innets B, Angkanaporn N, Suntornchot P, Panyain W, et al. A Randomized Double‐Blind Controlled Evaluation of the Therapeutic Benefits of an Herbal Lip Hydrant. Journal of Cosmetic Dermatology. 2025;24(3). doi:10.1111/jocd.70041
  6. Naga Ganesh M, Govinda Rao Kamala. The Role of Herbal Cosmeceuticals in Skin Care. Journal of Pharma Insights and Research. 2025;3(5):078-088. doi:10.69613/svt6tx36
  7. Gaurang K Parmar, Shubham Singh, Sanjesh Rathi. Recent Advances in Novel Drug Delivery System for Antidepressants: Emphasis on Gastroretentive and Sustained-Release Technologies. The Bioscan [Internet]. 2026 Apr. 14 [cited 2026 Apr. 28];21(2):158-75. Available from: https://thebioscan.com/index.php/pub/article/view/5614
  8. Mehak preet kour, Drashti patel, Harshil patel, Darshan mistri, Akshat patel, Mrs. Chandni Panchal. Formulation and Evaluation of Lip balm prepared using beet root extract. International Journal For Multidisciplinary Research. 2024;6(4). doi:10.36948/ijfmr.2024.v06i04.25355
  9. Fatima Grace X, Himana Begam K, Janani A, Jayaram M. Formulation and evaluation of natural lip balm. International Journal of Pharmaceutical Chemistry and Analysis. 2024;11(2):184-187. doi:10.18231/j.ijpca.2024.027
  10. P. Panchal J, Rathi S, Singh S. Nanoparticles for Pulmonary Drug Delivery System: A Review of Recent Development. J Neonatal Surg [Internet]. 2025 Dec. 7 [cited 2026 Apr. 28];14(33S):981-9.
  11. Kansara V, Rathi S, Singh S. Solid Self-Microemulsifying Drug Delivery Systems (S-SMEDDS): Advances in Oral Bioavailability Enhancement. J Neonatal Surg [Internet]. 2025 Dec. 12 [cited 2026 Apr. 28];14(33S):990-1003.
  12. Ananda A, Rosanti AS, Dwiningrum R, Suswidiantoro V. Optimization of Lip balm Formulation Containing Beetroot Extract (Beta Vulgaris L.) With a Combination of Grapeseed oil and Avocado oil Using the Simplex Lattice Design Method. JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI). 2026;4(3):322-332. doi:10.36002/js.v4i3.4318
  13. Prakash Kumar, Aradhya, Sandeep Kumar, Rohini Mishra. Formulation and Evaluation of Herbal Lipstick by Using Beta Vulgaris (Beet Root): A Review Paper. International Journal of Scientific Research in Science and Technology. 2025;12(4):139-150. doi:10.32628/ijsrst2512607
  14. Terse P, Mane S, Patil T, Ruke S, Mane G. Natural Protection: The Benefits of Herbal Lip Balm for Healthier Lips. Research Journal of Topical and Cosmetic Sciences. 2025;16(2):111. doi:10.52711/2321-5844.2025.00018
Support