Research & Reviews: A Journal of Drug Formulation, Development and Production
Volume 2, Issue 3 (2015)
Published
Table of contents
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Spherical Crystallization: Making Biopharmaceutical Parameters Tilorable
Abstract: Particle engineering is quiet important now a days. It should have good flow and compression properties for good tableting ability and render it suitable for advanced tableting devices. From years dry and wet granulation serves the purpose but since last two decades direct compression has achieved much attention amongst Pharma industry. In order to make the powder blend directly compressible Spherical crystallization methods have been developed; to make it appropriate …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 3, 2015 · pp. 1–12 Read article
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Formulation and Evaluation of Gastro retentive Effervescent Floating Tablets of Famotidine: Effect of Formulation Variables and In Vitro In Vivo Evaluation
Abstract: Gastro retentive effervescent floating tablets of famotidine were developed in an attempt to sustain the drug release as well as to prolong the presence of dosage form in the stomach or upper small intestine until drug is completely released in desired period of time from the formulation with special emphasis to the effect and concentration of different polymers on drug release and floatation. Tablets were prepared by direct compression method …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 3, 2015 · pp. 13–29 Read article
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Design and Development of Sustained Release Tablets using Solid Dispersion of Beclomethasone Dipropionate
Abstract: In present study an attempt was made to enhance the solubility of beclomethasone dipropionate by solid dispersion method followed by formulating sustained release matrix tablet of beclomethasone dipropionate to improve the patient compliance. Beclomethasone dipropionate has poor water solubility and short elimination half-life hence solid dispersion of beclomethasone dipropionate were prepared with β-cyclodextrin and PEG 6000 as carrier by using physical mixture, solvent evaporation and kneading method. The prepared solid …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 3, 2015 · pp. 30–41 Read article
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Formulation of Vancomycin Capsules and Characterization of Related Substances
Abstract: Aim of this research work was to develop vancomycin capsules and analysis of the related substances which was performed using HPLC and mass spectrometer. The impurities present in the formulation were identified and the two unknown impurities present at RRT about 0.65 and 2.10, were isolated, purified and characterized. The first impurity was found to be a polar substance and it was found to arise due to the amide cleavage …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 3, 2015 · pp. 42–51 Read article
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HPLC Method Development and Validation for Simultaneous Estimation of Succinic Acid and Succinylmonocholine in Succinylcholine Chloride Injection
Abstract: Succinylcholine chloride injection USP is a sterile, non-pyrogenic solution to be used as a short-acting, depolarizing, skeletal muscle relaxant. The injection is administered as IM or IV use. Succinylcholine chloride, USP is chemically designated C14H30N2O4 and its molecular weight is 290.399. Succinylcholine chloride has three known impurities: (1) Doublet peak, (2) Succinic acid and (3) Succinylmonocholine chloride. Out of these impurities, succinic acid and succinylmonocholine chloride are degradation impurities, whereas …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 3, 2015 · pp. 52–60 Read article