Research & Reviews: A Journal of Drug Formulation, Development and Production
Volume 6, Issue 2 (2019)
Published
Table of contents
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Herbal Treatment for Diabetes Mellitus
Abstract: Diabetes is nothing but metabolic disorder in which blood sugar is high. There are many symptoms associated with high blood sugar like frequent urination, increased thirst and hunger. Complications in diabetes can be of two types acute or severe, acute complications include diabetic ketoacidosis, hyperglycemia or death while serious includes complications like cardiovascular disease, stroke, chronic kidney disease, foot ulcers and damage to eyes. Medications to treat diabetes used to …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 1–5 Read article
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Formulation and Evaluation of Curcumin Loaded Transferosomal Nasal In-Situ Gel for Alzheimer’s Disease
Abstract: Objective: To develop a novel delivery of curcumin by formulating its transfersome into nasal in situ gel. Methods: Curcumin transfersomes were prepared by thin film hydration method. Optimization of the formulation was performed using Design Expert software. Formulation and characterization of optimized batch of curcumin transfersomes were performed. The nasal in situ gel was prepared by incorporating the optimized transfersome. Results: The pH, drug content, in-vitro drug release profile and …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 19–31 Read article
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Formulation and Evaluation of Solid Lipid Nanoparticles of BCS Class II Drug
Abstract: In the present study, we explored the potential of antihypertensive drug loaded solid lipid nanoparticles (SLNs), as a new formulation in improving the oral bioavailability of drug, which otherwise reported with poor bioavailability. The problem of poor water-solubility has remained as a significant challenge in pharmaceutical industry. The reduction of drug particle to the nano-level increases the surface area and improves solubility and dissolution of drug and proportionate increase in …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 32–54 Read article
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In-Vitro Evaluation of Extended Release Atorvastatin Tablets by using Natural Gums
Abstract: The present research is the formulation of extended-release tablets Atorvastatin is used as a hypoglycemic agent; it is HMG CoA Reductase inhibitor. All the formulation were prepared with using different grades of xanthan gum, guar gum, sodium alginate, then all the formulations were subjected to pre-compression and post-compression parameters such as angle of repose, bulk density, tapped density, Carr’s index, Hausner's ratio, weight variation, thickness, hardness, friability and drug content. …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 55–62 Read article
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Formulation Development and Evaluation of Furosemide Loaded Solid Lipid Microparticles
Abstract: Furosemide is a loop diuretic because of having very low half-life, low oral bioavailability, degraded in gastric juice; it was chosen to formulate as the solid lipid microparticle (SLMs) to overcome above. In this study, an attempt was made to improve the oral bioavailability of furosemide by preparing SLMs using stearic acid (SA) and cetostearyl alcohol (CsA) as lipid polymers by hot homogenization method at different drug: polymer ratios (1:5, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 6–18 Read article