Research & Reviews: A Journal of Drug Formulation, Development and Production
Volume 5, Issue 1 (2018)
Published
Table of contents
-
Formulation and Evaluation of Hybrid Polymer Films using Metformin as Model Drug
Abstract: The present work was to formulate transdermal films which can produce a constant and prolonged release of drug using Chitosan and polyethylene oxide. In the present study high molecular weight Chitosan (300 K) and Polyethylene oxide (600 K) were used.initially, pre-formulation studies were performed to check the solubility of drug and polymers. A suitable method was developed for the estimation of absorption maxima of the drug by UV double beam …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 1, 2018 · pp. 1–15 Read article
-
Nephroprotective Effect of Exogenous Melatonin and Plant Extract of Costus Igneous Nak
Abstract: Present study was designed to evaluate the nephroprotective effect of exogenous melatonin and insulin plant extract against diabetic induced renal alterations. Diabetic rat model was developed by intraperitoneal treatment of STZ to adult female rat (15 mg/kg) for continuous 6 days. Diabetes was confirmed by checking the blood glucose level. Following confirmation and successful induction, rats were randomly divided into six different groups group viz. group-I (control), group-II (Diabetic control), …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 1, 2018 · pp. 16–24 Read article
-
Role of Vanadium Salicylic acid coordination Complex in Diabetic cataract induced InVitro in Goat lens
Abstract: Diabetes is one of the major health problems that affect a large number of human populations. Diabetic cataract is one of the most frequent ocular complications rising secondarily to diabetes Vanadium and its various coordination metal complex plays a significant role in reduction of diabetes as well as cataract. We had tried to find out that the synthesized complex of Vanadium –Salicylic acid had a role on diabetic cataract induced …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 1, 2018 · pp. 25–28 Read article
-
Selective Inhibitors of Nuclear Exports—A Novel Anti-Cancer Drug Class: The Review Study
Abstract: For the maintenance of cell homeostasis nucleus-cytoplasmic transport is of great concern. The transport is basically depending on a size of molecule. In different hematological and solid malignancies, the CRM1 is overexpressed so the agents are requiring that particularly inhibit the exportins of nuclear export. This concept favors the SINEs development. The objective of this review study is to understand all about the novel anticancer drugs and their uses in …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 1, 2018 · pp. 29–36 Read article
-
Method, Development and Validation of Emtricitabine and Tenofovir by Using RP-HPLC in Pharmaceutical Dosage Forms
Abstract: A new method was established for simultaneous estimation of Emtricitabine and Tenofovir by RP-HPLC method. The chromatographic conditions were successfully developed for these parathions of Emtricitabine and Tenofovir by using Xterra C185 µm (4.6*250 mm) column, flowrate was1ml/min, mobile phase ratio was phosphate buffer (0.05 M) pH4.6: CAN (55:45% v/v) (pH was adjusted with ortho-phosphoric acid), detection wavelength was 255nm. Theretentiontimewas2.399and3.907 min. for Emtricitabine and Tenofovir, respectively. The percentage purity …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 1, 2018 · pp. 37–41 Read article