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206 articles for “ACE 2”
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Zeolite-Y Encapsulated Copper (II) and Cobalt (II) Species as Hybrid Nano-catalysts: Structural and Catalytic Aspects
Abstract: Special properties inherent to zeolites in facilitating the construction of novel supramolecular assemblies by encapsulation of guest molecules (metal complexes) into their large cages can be utilized to use these assembled materials as novel catalysts. These modified solids have the advantages of both behaving as the homogeneous and the heterogeneous catalytic system. In the present work, copper (II) and cobalt (II) complexes of 2-amino ethanoic acid (2-AEA) encapsulated in the …
Published in Journal of Catalyst & Catalysis · Vol. 8, Issue 1, 2021 · pp. 19–32 Read article
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Formulation and Evaluation of Microballoons of Ramipril
Abstract: The present study was an attempt to develop microballoons of Ramipril to prolong gastric residence time in stomach and to control drug release in therapeutic range. Ramipril is ACE inhibitor having short half-life of 2–4 h and bioavailability 28%. Microballoon was formulated using Eudragit E100 and HPMC K4M in different ratios by emulsion solvent evaporation technique using methanol as evaporating solvent and liquid paraffin as a processing medium. Microballoons were …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 2, 2018 · pp. 13–30 Read article
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Development of Validated Stability Indicating RP-HPLC Method for Amisulpride Injection
Abstract: Objective of the present work is to develop and validate a simple, cost effective, sensitive and fast RPHPLC method for the analysis of Amisulpride injection. A Waters HPLC system with Octacysilane 150 mm × 4.6 mm column is employed for the analysis using pH 4.5 phosphate buffer solution, acetonitrile and methanol in the ratio of (75:20:5 v/v) as mobile phase. Signal from Amisulpride is detected at 280 nm by UV …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 1, 2023 · pp. 24–40 Read article
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Determination of the Antidiabetic Drug Miglitol in Pharmaceuticals by Ultra-Performance Liquid Chromatography
Abstract: Miglitol (MGL) is a drug used in the treatment of type-2 diabetes mellitus. A new analytical method employing ultra-performance liquid chromatography (UPLC) with UV-detection is presented for the determination of MGL in bulk drug and tablet forms. Analysis was performed in less than 3 min in isocratic mode on a reversed phase BEH C18 (100 mm × 2.1 mm; 1.7 µm particle size) column using phosphate buffer of pH 3.7-acetonitrile …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 9, Issue 2, 2018 · pp. 11–26 Read article
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Optimizing Chromatographic Techniques for Comprehensive Paraben Analysis to Enhance Safety in Consumer Products
Abstract: Parabens (PBs), such as methylparaben (MePB), ethylparaben (EtPB), propylparaben (PrPB), and butylparaben (BuPB), are widely used as preservatives in pharmaceuticals, food, and personal care products due to their antibacterial properties. However, there are growing worries about their potential to disrupt hormonal functions, which has led to stricter regulations. This study focuses on creating a robust high-performance liquid chromatography (HPLC) method for quickly measuring all four parabens in consumer goods. We …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 228–243 Read article
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HPTLC Fingerprinting of Isoflavonoids and Metabolites Quantification from in vivo and in vitro Developed Parts of Pueraria tuberosa (Willd.) DC
Abstract: Pueraria tuberosa (Willd.) DC, a medicinally important plant, produces different types of isoflavonoids including Genestein. This plant requires conservation. In present study, callus was developed from in vivo tuber and in vitro seedling. Murashige and Skoog medium supplement with combination of BAP (6-Benzylaminopurine) (1.5mg/l) and 2,4-D (1.5mg/l) were found to be more effective. Fresh in vitro shoots produced from nodal explants of in vitro germinated seedling on MS medium supplement …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 3, 2019 · pp. 34–45 Read article
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Toxicology-Focused Development and Validation of an RP-HPLC Technique for Quantifying Bempefoic Acid and Rosuvastatin in a Fixed-Dose Combination
Abstract: A straightforward, precise method was developed to simultaneously assess Bempedoic acid and Rosuvastatin in both bulk and tablet forms. Utilizing a DIKMA Spursil C18 column (4.6 mm x 250 mm, 3.0 μm), chromatography was conducted with a mobile phase comprising 30% phosphate buffer and 70% acetonitrile, flowing at 1 ml/min. Operating at ambient temperature, the optimized wavelength for detection was set at 240 nm, revealing retention times of 4.418 min …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 1–9 Read article
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Stability Indicating HPLC Method for Drugs Indicated for Helicobacter Pylori-associated Ulcers
Abstract: Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 Triple therapy regimen that comprises a proton pump inhibitor likes Omeprazole, antibiotics like Doxycycline and Tinidazole can be used for treatment of peptic ulceration which is caused by H. pylori. A validated HPLC method was developed as a stability-indicating HPLC method for these drugs and its impurities. New method overcame interference between Doxycycline and its epimer on achiral column by using …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 1, 2015 · pp. 28–46 Read article
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A New RP-HPLC Method for Simultaneous Estimation of Atorvastatin and Fenofibrate in Its Bulk and Tablet Dosage Form
Abstract: Objective: A New method was established for simultaneous estimation of Atorvastatin and Fenofibrate by RP-HPLC method. Methods: Chromatographic separations were carried using Phenomenex C18 column (4.6 × 250 mm, 5 µm) column with a mobile phase composition of 0.1 M Ammonium acetate:acetonitrile (60:40) have been delivered at a flow rate of 1ml/min and the detection was carried out using waters HPLC auto sampler, separation module 2695 with PDA detector at …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 3, 2023 · pp. 12–18 Read article
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Responses of Phytoplankton Community Structure to Polycyclic Aromatic Hydrocarbon Constituents in Imo River, Oyigbo, Niger Delta, Nigeria
Abstract: Phytoplankton perform a pivotal role in the food chain and serve as indicator species in environmental studies. Polycyclic aromatic hydrocarbons (PAHs) are toxic group of divergent chemicals with two or more aromatic rings coalesce side by side representing serious persistent organic contaminants posing environmental risk to aquatic life and human. Imo River receive contaminants from illegal oil refinery. The study was conducted to assess the responses of phytoplankton community structure …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 1, 2025 · pp. 45–53 Read article
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Formation, Analysis and Characterization of Wood Pyrolysed Oil
Abstract: Pyrolysis of wood is the possible path for converting biomass to higher valuable products such as bio-oil, bio-char and bio-gas. Bio-oil or liquid bio-fuels have higher heating values, so it can store and transport more conveniently the by-products bio-char and bio-gas, which can be used to provide heat required in the process. This work is focused on the formation, analysis and characterization of bio-oil which was obtained from the mixed …
Published in Emerging Trends in Chemical Engineering · Vol. 3, Issue 2, 2016 · pp. 36–41 Read article
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Isolation and Partial Characterization of a Lectin from Seeds of Pongamia Glabra
Abstract: Lectins are non-immunogenic proteins that selectively bind carbohydrates without processing them enzymatically.They have wide range of applications in agricultural and biomedical research and it is useful in the antidotal treatment of snake bite. Seed lectins can be attributed to the importance of legume seeds as a rich source of dietary protein. The Pongamia glabra were homogenized by using distilled acetone. The defatted dried seed meal was mixed with 20mm Phosphate …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 1, Issue 1, 2011 · pp. 87–95 Read article
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Reactivity of Monochlorotetrakis2-Isopropylphenoxoniobium(V), [NbCl(OC6H4CH(CH3)2-2)4] towards Chelating Ligands
Abstract: The niobium(V) complexes with the formula [NbCl(OC₆H₄CH(CH₃)₂-2)₄] were successfully synthesized in high yields through the reaction of niobium pentachloride with four equivalent amounts of 2-isopropylphenol in carbon tetrachloride. The synthesized complexes were characterized and confirmed by elemental analysis, molar conductance measurements, infrared (IR) spectroscopy, ^1H and ^13C NMR spectroscopy, as well as mass spectrometric analysis. The spectroscopic studies have shown these to exhibit dimeric structures bridging through isopropylphenoxo groups. The …
Published in International Journal of Minerals · Vol. 3, Issue 1, 2026 · pp. 37–45 Read article
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HPTLC Method Development and Validation for Rabeprazole Sodium in Pharmaceutical Formulation
Abstract: Background: The most common medication for acid related disorders stands as Proton pump inhibitor (PPI) Rabeprazole Sodium. The pharmaceutical formulations require essential quality control of Rabeprazole Sodium through reliable analytical methods to maintain reliability. HPTLC provides a cost-effective rapid method for drug quantification compared to conventional HPLC methods so how HPTLC stands as an appropriate method for drug determination. Objective: The emphasis of this research project involves developing and validating …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 18–24 Read article
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Preliminary Phytochemical Screening, Antioxidant and antibacterial activity of Helicteres isora leaf extracts.
Abstract: Objective: To evaluate phytochemical screening, Anti-oxidant and anti-bacterial activity of Helicteres isora leaf extracts. Methods: Petroleum ether, chloroform, acetone, ethanol and hydroalcoholic extracts of leaves were used for the phytochemical screening. Anti-oxidant activity was measured using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide (No) radical scavenging tests; antibacterial activity was assessed using disc diffusion techniques. Results: The percentage yields for the petroleum ether, chloroform, acetone, ethanol and the hydroalcoholic extract were …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 13, Issue 2, 2022 · pp. 11–17 Read article
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Supplementing Wheat Protein to Improve and Complement Its Nutritional Quality
Abstract: Protein concentrates from lobia seeds, soybean, hyacinth beans and milk (casein and whey) were prepared following isoelectric precipitation. The percent moisture/protein content of these concentrates was 5.01±0.03/84.81±2.19; 5.15±0.06/86.60±1.66; 5.11±0.03/83.28±1.42, 8.19±0.15/86.03±0.68 and10.21±0.04/77.5±0.68 respectively. Acidic and alkaline hydrolysis of these concentrates was carried out in steam under pressure conditions (121°C) at different time intervals (60, 120 and 180 min). Hydrolysis treatment in both the conditions for 180 min resulted into improved separation …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 4, Issue 2, 2015 · pp. 13–20 Read article
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Chemical Constituents and Tyrosinase Inhibitory Activity of Ethyl Acetate Extract of the Leaves of Morus alba L. from Vietnam
Abstract: AbstractFour compounds (DB1–4) were isolated from the Mulberry leaves (Morus alba L.) collected in Thai Nguyen province by chromatographic methods. These compounds were identified as: Kaempferol-3-O-β-D-glucopyranoside (DB1), quercetin 3-O-α-L-rhamnopyranoside (DB2), isofraxidin-7-O-β -D-glucopyranoside (DB3), and (±) -3, 5, 6, 7, 8, 4’-hexahydroxyflavane (DB4). Their structures were elucidated by spectroscopic methods, including mass spectrometry (MS) and nuclear magnetic resonance (NMR). Compound DB4 was isolated from Mulberry leaves for the first time. Compound …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 1, 2018 · pp. 21–26 Read article
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Brain GST Inhibition, An Additional Mode of Action Following Beta-Cyfluthrin Intoxication in Albino Rat
Abstract: The aim of the study was to reveal the neurotoxic effect of an orally administered beta-cyfluthrin, a type-II pyrethroid in albino rats on the basis of activity of brain GST (Glutathione-s-transferase), AChE (acetylcholinesterase) and of total proteins level at different doses 35.48 and 5.06, 2.53, 1.68, 1.27 mg/kg body weight, for acute (1 day) and sub-acute (7, 14, 21 and 28 days) treatments respectively. Results reveal that beta-cyfluthrin administration inhibits …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 3, 2014 · pp. 30–36 Read article
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Exploring the Bioactive Potential of Himalayan Lichens: Phytochemical and Antimicrobial Profiling of Xanthoparmelia tinctina and Pyxine subcinerea Extracts
Abstract: The symbiotic association that develops between cyanobacteria, algae, and fungi results in the composite organism known as lichens, which has traits similar to those of plants but differs in its separate parent organisms. Lichens can have a variety of morphological characteristics, including foliose structures that resemble flat leaves, crustose structures that resemble flake crystals, fruticose branches that have short, leafless branches, and leprose-powder-like appearances. Due to their therapeutic potential, lichens …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 2, 2024 · pp. 21–28 Read article
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Structural, Optical, Surface, and Gas-Sensing Properties of rGO/Sn1–xZnxO₂ Nanocomposites
Abstract: rGO/Sn₁–ₓZnₓO₂ nanocomposites with x = 0.00–0.75 were synthesized by sol–gel auto-combustion followed by wet impregnation with reduced graphene oxide. The adopted synthesis route enabled homogeneous Zn incorporation into the SnO₂ matrix and uniform distribution of rGO, leading to improved structural integrity and interfacial contact between the two components. XRD confirmed a dominant tetragonal cassiterite SnO₂ structure, while FTIR, FESEM, EDS, UV–visible, and BET analyses verified oxide–rGO coupling, Zn-dependent structural modification, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 429–452 Read article