Research and Reviews: A Journal of Pharmacology

Latest articles

• Published Subscription Original Research 13 Jun 2026

  Molecular Docking, QSAR Modeling, and ADMET Evaluation of Novel Pyrazolo-Pyrimidine Derivatives as Potential CDK-2 Inhibitors for Cancer Therapy

  By Anu Boora, Sunil Kumar

  Abstract: Cyclin-dependent kinase-2 (CDK-2) is an essential regulator in cell cycle progression and is an important therapeutic target in cancer drug development. In the present study, an integrated computational approach involving molecular docking studies, QSAR modeling, ADMET prediction, and artificial intelligence-based analysis was used to identify pyrazolo-pyrimidine derivatives as potential CDK-2 inhibitors. Based on the molecular docking results, it was found that selected compounds exhibited high binding affinity towards the ATP …

  Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article →

• Published Subscription Review Article 2 Jun 2026

  Non-Small Cell Lung Cancer: Types, Pathogenesis, Diagnosis, and Novel Therapeutic Strategies

  By Nandini Rajendra Jadhav, Dipti R. Rajput, Devyani V. Dhangar, Puja R. Chavhn

  Abstract: Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, accounting for over 85% of all cases globally. It remains one of the primary causes of cancer-related death due to its rapid progression, few early symptoms, and late detection. The three main forms of non-small cell lung cancer (NSCLC) are adenocarcinoma, squamous cell carcinoma, and giant cell carcinoma; each has a unique histology, prognosis, and response to …

  Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article →

• Published Subscription Review Article 2 Jun 2026

  Pharmacodynamics and Drug–Receptor Interactions: Integrating PK/PD Modeling with Modern Drug Development

  By Aayush K. Ramraje, Vilas K. Patil, Avinash V. Kapure, Dhiraj R. Girase, Akshata M. Girase, Bhupendra M. Mahale, Ghanshyam M. Chavan

  Abstract: Understanding drug action requires an integrated perspective of pharmacodynamics and pharmacokinetics, which together determine therapeutic efficacy and safety. This review provides a comprehensive overview of the mechanisms underlying drug action, with particular emphasis on drug–receptor interactions and their role in modulating physiological responses. Drugs exert their effects primarily through interactions with specific biological targets, including receptors, enzymes, ion channels, and transporters, resulting in a spectrum of desired and adverse outcomes. …

  Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article →

• Published Subscription Original Research 10 May 2026

  Evaluation of Anti-cataract Potential of Carbocisteine by Using In Vitro Goat Lens Model

  By Pratik A. Bhand, Hemant J. Pagar

  Abstract: This study includes Carbocisteine has four Oxygen molecules, one Sulfur molecule, and one Nitrogen molecule. Goat eyeballs were used in the present study. They were obtained from the slaughterhouse. Glucose at a concentration of 55 mM was used to induce cataracts; glucose (5.5 mM) concentration served as a normal control, and Ascorbic Acid served as a standard control. Incubation of lenses with glucose 55 mM showed opacification starting after 8 …

  Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article →

• Published Subscription Original Research 4 May 2026

  In Silico Screening and Molecular Docking of Cynodon dactylon phytochemicals against COPD-Associated Proteins

  By Namita Krishnakumar, Deekshitha M

  Abstract: Chronic Obstructive Pulmonary Disease or COPD is a pulmonary disease that obstructs airways and alveoli accompanied by respiratory issues like emphysema and bronchitis. This disease is caused mainly by inflammatory responses of the body to foreign particles that enter the respiratory path including tobacco smoke, air pollutants and irritants. The hallmark of COPD is excessive inflammation caused by imbalance in protease anti-protease activity. Proteases like elastase breakdown the ECM of …

  Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article →

• Published Subscription Review Article 2 May 2026

  Modern Approaches in Lung Cancer Management from Herbal Nanomedicine to Artificial Intelligence

  By Harshala K. Patil, Akash S. Jain, Divakar R. Patil, Azam Z. Shaikh, Sameer R. Shaikh, Priya N. Chaudhari, S. P. Pawar

  Abstract: Lung cancer continues to be a major global health concern and one of the leading causes of cancer-related mortality worldwide. Despite significant advancements in therapy, there is still a pressing need for safer and more effective therapeutic alternatives; problems such drug resistance, side effects, metastasis, and recurrence continue to impact patient outcomes and quality of life. Examining current advancements in the use of herbal drug-loaded nanoparticles as a novel approach …

  Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article →

• Published Subscription Review Article 26 Apr 2026

  Consumer Awareness and Adoption Barriers of E-Pharmacy Services in Delhi/NCR: A Mixed-Methods Investigation

  By Tarun Chopra, Nidhi Bhasin

  Abstract: Background: The rapid digitization of India's pharmaceutical market has positioned e-pharmacies as a transformative force; yet, consumer adoption remains significantly low despite growing awareness. Objectives: This study investigates consumer awareness levels, purchasing behaviors, trust perceptions, and adoption barriers regarding e-pharmacy services among urban Indian consumers. Methods: A sequential explanatory mixed-methods design was employed. Quantitative data were gathered via a structured questionnaire administered to 65 respondents in Delhi. Qualitative insights were …

  Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article →

• Published Subscription Review Article 26 Apr 2026

  SGLT2 Inhibitors in Heart Failure and Chronic Kidney Disease: Expanding Therapeutic Horizons beyond Glycemic Control

  By Hamsa Priya M, Bharath B, Darshan G

  Abstract: Heart failure (HF) and chronic kidney disease (CKD) are closely related clinical diseases that significantly increase morbidity and death worldwide. The co-occurrence of both conditions is frequently referred to as the "cardio-renal syndrome," in which the failure of one organ hastens the decline of the other. The original purpose of sodium–glucose cotransporter-2 (SGLT2) inhibitors was to treat type 2 diabetic mellitus (T2DM) by reducing blood sugar levels. Nevertheless, new data …

  Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article →

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