Formulation and Evaluation of Microballoons of Ramipril

Sonam M Gandhi; Bhumika Patel; Roopa Karki; Atit Pandey; Divakar Goli; Kanchan Singh

doi:10.37591/rrjodfdp.v5i2.115

Abstract

The present study was an attempt to develop microballoons of Ramipril to prolong gastric residence time in stomach and to control drug release in therapeutic range. Ramipril is ACE inhibitor having short half-life of 2–4 h and bioavailability 28%. Microballoon was formulated using Eudragit E100 and HPMC K4M in different ratios by emulsion solvent evaporation technique using methanol as evaporating solvent and liquid paraffin as a processing medium. Microballoons were characterized for micromeritic properties, drug entrapment efficiency, in vitro buoyancy, drug polymer compatibility study, scanning electron microscopy and in vitro release studies. Microballoons were white, free flowing and spherical in shape. It showed 53.23–86.03% of entrapment and release extended up to 12 h. Two months of stability study was carried out at 30±2°C (65±5%RH) for best F8 formulation which showed no significant changes in % drug entrapment efficiency and in vitro release study. Keywords: Microballoons, Ramipril, Eudragit E100, HPMC K4M, emulsion solvent evaporation method, stability studyCite this ArticleGandhi Sonam M, Bhumika Patel, Roopa Karki, et al. Formulation and Evaluation of Microballoons of Ramipril. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2018; 5(2): 13–30p.