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1071 articles for “interactive”
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Identification of Hub Genes and Enriched Gene Ontology & Pathways in Idiopathic Pulmonary Fibrosis Through Bioinformatics Approaches
Abstract: Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease marked by aberrant remodeling of lung tissue and excessive extracellular matrix deposition, ultimately leading to respiratory failure. Despite ongoing research, the molecular mechanisms underlying IPF remain incompletely understood. This research aims to uncover differentially expressed genes (DEGs) and related biological pathways through an integrated analysis of microarray data. Two publicly available datasets, GSE110147 and GSE53845, were obtained from the Gene …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 1–13 Read article
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Modulating Immune System of Mosquitoes with A Novel Salicylate Derivative: A Bioinformatics-Based Study
Abstract: The present study aims to compare the interactions of a novel derivative of salicylic acid, 5-(2-nitroethynl) salicylic acid (5-SANA, salicylic acid nitroalkene), and salicylic acid with the critical residues of mosquito’s juvenile hormone binding protein (mJHBP). Given the better water solubility of 5-SANA and salicylic acid, it is believed that they can interact quicker than the natural substrate, juvenile hormone (JH), with the cavity of mJHBP, a circulating protein in …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 · pp. 1–5 Read article
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Adverse Drug Reactions: A Global Health Challenge
Abstract: An adverse drug reaction (ADR) is an unfavorable event with a causal connection to the medication. It is an undesirable event caused by a pharmacological substance. They are a major cause of Mortality all over. They are classified into augmented, chronic, bizarre, and delayed based on the severity of the damage they cause. The primary causes of adverse drug reactions (ADRs) are drug overdose, drug-drug interactions, genetic variations, and individual …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Seismic-Resilient Structural Systems: Geotechnical Engineering
Abstract: Earthquakes represent one of the most destructive natural hazards, capable of causing severe structural damage, loss of life, and substantial economic disruption. Seismic waves propagating through the ground can induce excessive forces and deformations in buildings, often leading to partial or complete collapse. Statistical records indicate that thousands of earthquakes occur globally each year, including several major events that result in significant damage. Past earthquake disasters have repeatedly demonstrated that …
Published in Journal of Geotechnical Engineering · Vol. 13, Issue 1, 2026 · pp. 55–63 Read article
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Integrated Surface Water–Groundwater Dynamics: Implications for Pollution Pathways, Prevention, and Environmental Control
Abstract: Water resources worldwide are increasingly threatened by pollution pressures amplified by climate change and intensified human activities. The vulnerability of surface water and groundwater systems to contamination is strongly governed by their dynamic hydrologic connectivity, which is often overlooked in pollution prevention and control frameworks. Rising global temperatures, altered precipitation regimes, land-use change, and intensified abstraction patterns modify recharge processes, flow paths, and contaminant transport mechanisms across environmental landscapes. This …
Published in International Journal of Pollution: Prevention & Control · Vol. 4, Issue 1, 2026 · pp. 34–40 Read article
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Pharmacokinetics of Levothyroxine and Factors Influencing Its Therapeutic Efficacy in Hypothyroidism: A Comprehensive Review
Abstract: Levothyroxine (LT4) remains the standard therapy for hypothyroidism due to its effectiveness in restoring normal thyroid hormone levels and improving physiological functions. However, its pharmacokinetic profile exhibits considerable variability, which may influence therapeutic outcomes in clinical practice. This review aims to comprehensively evaluate the pharmacokinetics of levothyroxine, including its absorption, distribution, metabolism, and elimination, along with factors affecting its therapeutic efficacy. A structured literature search was conducted using electronic databases, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 Read article
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A Review on Hybrid Inorganic–Polymer Analog Nanocomposites Incorporating Pozzolanic Wastes and nano-Additives
Abstract: The recent progress of polymer matrix nanocomposites (PMNCs) reveals that the performance of matrix and filler is at the core of matrix–filler interaction, interfacial bonding, and well-controlled distribution of nanoscale reinforcements. Applying these concepts, we consider inorganic particulate systems as hybrid nanocomposites, in which a discontinuous inorganic matrix is effectively reinforced via synergistic co-incorporation of pozzolanic wastes and nano-additives. In the composite system described above, silica-, alumina-rich pozzolanic materials serve …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 131–141 Read article
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A Comprehensive Review on the Role of Antacids in the Management of Stomach Disorders
Abstract: Antacids are among the most widely used over-the-counter medications for the symptomatic management of acid-related gastrointestinal disorders, including dyspepsia, gastroesophageal reflux disease (GERD), gastritis, and peptic ulcer disease. These agents provide rapid relief by neutralizing gastric hydrochloric acid, thereby increasing intragastric pH and reducing mucosal irritation. In addition to their therapeutic benefits, the long-term and excessive use of antacids may be associated with adverse effects and toxicological concerns, including electrolyte …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 2, 2026 Read article
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Role of Electron Donors in MgCl2 Supported Ziegler-Natta Catalysis: DFT Approach
Abstract: An insight into the nature of carbonate-based electron donors in high-activity MgCl2 supported Ziegler-Natta (Z-N) catalysts has been studied and compared with conventional phthalate and diether systems by employing density functional theory (DFT) calculations. In the catalyst activation (one of the important processes to produce the active catalyst sites), the conventional monometallic and recently characterized bimetallic (TiCl2(Et)–Cl–AlEt2) active site are studied in the presence/absence of electron donors. These active sites …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 2, 2025 · pp. 51–81 Read article
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POLYMER AND COMPOSITE-BASED GEOSYNTHETIC REINFORCEMENTS FOR SEISMIC STABILITY OF SOIL RETAINING STRUCTURES: MATERIALS, MECHANICS, AND PERFORMANCE REVIEW
Abstract: Geosynthetic materials based on polymer and composites have become important items for the structural performance and seismic resilience of the reinforced soil retaining systems. Mechanically stabilized earth walls in recent geotechnical engineering practice are increasingly based on enhanced polymeric reinforcements for enhanced tensile strength, durability, flexibility, and energy dissipation under dynamic loading. High-density polyethylene, polypropylene, polyester, and fiber-reinforced polymer composites are usually used. The present review focus on the recent …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Veterinary Immunology in Zoonotic Disease Control
Abstract: Zoonotic diseases, which are transmissible between animals and humans, pose a significant threat to global public health, food security, and economic stability. Veterinary immunology plays a pivotal role in understanding host–pathogen interactions, developing preventive strategies, and mitigating the impact of these diseases. Animals serve as reservoirs for a variety of pathogens, including viruses, bacteria, and fungi, which can persist asymptomatically or cause clinical disease. Understanding the immune mechanisms in both …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 3, 2025 · pp. 36–43 Read article
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Computational Molecular Docking Studies to Design Novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)-1H- indol-5-ol Derivatives for Estrogen Receptor Alfa in AF-2 Domain
Abstract: The present manuscript describes the designing of novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)- 1H-indol-5-ol derivatives as specific estrogen receptor alfa modulators and their screening by docking studies to determine the binding interaction for the best-fit conformations in the binding site of the ERα receptor. Based on the results of docking studies, the selected ligands reveal the all- important functional groups of the ligands that interact with active amino acid residues in the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 15–49 Read article
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Future-proofing the Mind: Fostering Robust Innovation in Soft Computing and Computational Intelligence
Abstract: This study examines the impact of Computer Science (CS) and Soft Computing (SC) on a few scholarly disciplines and way of life. The study considers points to improve calculation execution by utilizing computational intelligence (CI) techniques, progressing the steadiness of statistical classification (SC) models, and optimizing them through algorithmic upgrades. These adjustments encourage the method of altering, selecting, and creating oneself, indeed in challenging circumstances. The effect on work, protection, …
Published in Journal of Mobile Computing, Communications & Mobile Networks · Vol. 11, Issue 1, 2024 · pp. 1–6 Read article
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Role Strain Among Male Nursing Students in Selected Nursing Colleges in Mangalore
Abstract: Background: The role is the behavior that is expected out of a person in a particular status. Social standards influence the advantages and responsibility of a status, and roles are performed in accordance with social standards. Role strain is the stress that occurs if they are not able to meet the expected role in their life and are facing inequalities in their profession. Objective: To assess the role strain among …
Published in Journal of Nursing Science & Practice · Vol. 14, Issue 1, 2024 · pp. 6–11 Read article
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Comprehensive Review of Moebius Syndrome: Clinical Landscape, Etiology, and Therapeutic Challenges
Abstract: Moebius syndrome, a rare congenital neuromuscular disorder, presents with non-progressive facial weakness, limited eye abduction, and diverse manifestations affecting cranial nerves. This comprehensive review explores its clinical landscape, emphasizing the need for extensive investigations into its elusive etiology and genetic underpinnings. The estimated prevalence is 1 in 250,000 live births, with sporadic cases prevailing. Initial symptoms, evident from birth, encompass difficulties in sucking, and feeding, and absent facial expressiveness. Beyond …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 27–38 Read article
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Hand Gesture Control Robotic Arm using OpenCV and NodeMCU
Abstract: In this research paper, an innovative method is proposed for controlling a robotic arm through the use of hand gestures, utilizing the advanced features of Node MCU and OpenCV. By bringing together these cutting-edge technologies, the system enables seamless real-time communication and image processing between the user and the robotic arm. The process involves capturing hand gestures through a camera and using the powerful OpenCV library to identify and interpret …
Published in Journal of Semiconductor Devices and Circuits · Vol. 11, Issue 1, 2024 Read article
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Arduino Empowered: Smart Glove Review and Analysis
Abstract: In recent years, there has been a growing interest in wearable technology, particularly in the realm of human-computer interaction (HCI). Smart gloves, equipped with various sensors and actuators, have emerged as a promising interface for facilitating seamless interaction between humans and digital devices. This paper presents the development of Arduino-based smart gloves designed to augment conventional HCI methods by incorporating gesture recognition and tactile feedback capabilities. The smart gloves feature …
Published in Journal of Microcontroller Engineering and Applications · Vol. 11, Issue 1, 2024 Read article
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Ligand Based Drug Virtual Screening in Computer Aided Drug Design: A Review
Abstract: Computer-Aided Drug Design (CADD) has revolutionized the drug discovery process by providing efficient and cost-effective methods for identifying potential drug candidates. Within CADD, ligandbased virtual screening techniques play a pivotal role in the early stages of drug discovery. This review provides a comprehensive overview of ligand-based drug virtual screening, focusing on its principles, applications, challenges, and future directions. Fundamentals of ligand-based virtual screening, including pharmacophore-based methods, similarity searching, and machine …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 2, 2024 · pp. 1–8 Read article
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Quantitative Structure-activity Relationship in Computer-aided Drug Design: A Review
Abstract: Quantitative Structure-Activity Relationship stands at the forefront of Computer-Aided Drug Design, providing a systematic framework for understanding the relationship between the chemical structure of molecules and their biological activity. The present review delves into the multifaceted realm of quantitative structure-activity relationship methodologies within the landscape of drug discovery. Through an exploration of diverse quantitative structure-activity relationship models, molecular descriptors, validation techniques, and recent advancements, the present article aims to elucidate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 55–63 Read article
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Butrin Tackles Retinoblastoma – A Clinical Hypothesis †
Abstract: Breach of association of legumain protein activities to the corresponding cellular components results in over-expression of legumain, and constitutes a key biomarker for a variety of life-taxing sicknesses like cancer, Alzheimer’s/Parkinson’s and acute kidney injury. To suppress the functions of legumain, it is hypothesized that a water soluble and edible biomolecule, namely, butrin (7, 3’, 4’-trihydroxy flavanone-7, 3’-diglucoside) may have the therapeutic potential owing to its special ability to bind …
Published in International Journal of Advance in Molecular Engineering · Vol. 2, Issue 1, 2024 · pp. 26–30 Read article