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1972 articles for “4-dioxopyrimidine-5-carbonitrile” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Synthesis, Molecular Docking and Biological Evaluation of Novel Chlorobenzenesulfonamide Analogues of Ibuprofen as Anti-Bacterial, Anti-Diabetic and Anti-Alzheimer Agents
Abstract: In this work, we have synthesized novel chlorobenzensulfonamide tertiary amide based analogues of Ibuprofen (Ibu) and investigated them for their anti-bacterial, anti-diabetic and anti-Alzheimer activities. In the first step, Ibu was converted to amide derivatives by incorporating different aromatic amines. These were further converted into sulfonamide analogues (Sul-Ibu, 1-9) by treating it with p-chlorobenzensulfonyl chloride. Sul-Ibu (1-9) were screened against S. aureus, B. subtilis, S. mutans, E. coli, P. aeruginosa, …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 41–55 Read article
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Investigating The Mechanical Properties of Sisal/Areca/Sisal Natural Fiber Reinforced Composite Material Treated with NaOH and Filled with Al2O3 and Tio2
Abstract: Biopolymer-based composites which are obtained from the natural resources like plants, animal or mineral based have recently attracted significant interest because they can be used in interesting ways in biology and materials science. These materials are generally non-toxic, reusable, and recyclable, which are useful in many situations where sustainability and environmental protection are important. Plant Based fibers like Bamboo, Coir, Kenaf, Banana, Sisal, hemp and jute are proving their potentiality …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 413–425 Read article
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Effects of Tendon Gliding Exercises on the Speed of Handwriting Among Female UG Students: Pilot Study
Abstract: Background: Handwriting is an intricate function which requires the combination of fine motor skills, visual and motor coordination abilities, and concentration. Handwriting involves two main movements: horizontal wrist motion and vertical finger movements, along with a rightward translation of the entire arm. Handwriting speed is an important factor in a student’s academic performance, particularly in fields such as statistics. The strength and flexibility of hand muscles can significantly influence writing …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 1–6 Read article
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Soil Salinity Assessment and Irrigation Water Quality of Humbo Woreda, Wolaita Zone, South Ethiopia
Abstract: Soil salinity affects the majority of Ethiopia's irrigated farmland, and chemical properties of irrigation water quality have major role in assessing the irrigation land salinity. The study has the objective of determining the soil salinity and irrigation water quality. The study was conducted in Humbo Woreda, Wolaita Zone in the South Peoples’ Regional State. The study used standard analytical techniques and methods to analyze different physiochemical parameters of both irrigation …
Published in Journal of Water Resource Engineering and Management · Vol. 12, Issue 2, 2025 · pp. 38–51 Read article
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Enhancing Concrete Durability and Mechanical Properties for Pavement Quality Concrete (PQC) Roads Using Basalt Fiber Reinforcement
Abstract: Concrete, by nature, is brittle and has a very low tensile capacity, which is a double whammy in transportation infrastructure, such as pavement quality concrete (PQC), for roadways, where we need durability and strength. One such method is the use of basalt fibre, as it is a much better way of enhancing the road runway way performance of concrete. This research studies the impact of the addition of basalt fibres …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 266–280 Read article
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Production And Purification of Amylase Through Bacterial Strain
Abstract: Amylases are important industrial enzymes with use in detergents, brewing, and food processing because of their ability to hydrolyze starch. In this research, the production and optimization of α-amylase from a potato soil isolated bacterium using agro-waste as a carbon source is investigated. The isolate had a hydrolytic zone of 13.33 mm and the highest activity of 545 U/mL under submerged fermentation with 1% starch. Optimum conditions were pH 7.0, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 · pp. 1–10 Read article
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Thermo-Mechanical and Electrical Properties of Multi-Walled Carbon Nanotube-Enhanced Polyimide Composites for Aerospace Thermal Protection Systems
Abstract: Advanced aerospace thermal protection systems (TPS) require multifunctional materials that simultaneously provide high thermal stability, mechanical strength, and reliable electrical performance. Polyimide (PI) is widely used in aerospace structures due to its lightweight design and exceptional thermal durability, yet its low thermal conductivity and insulating behavior limit its effectiveness in heat dissipation and electromagnetic interference (EMI) shielding applications. This study addresses these limitations by developing multi-walled carbon nanotube (MWCNT)-reinforced polyimide …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 966–982 Read article
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Enhancement of Thermo-hydraulic Properties of a Novel Composite-Based Spiral Fin Tube Heat Exchanger: An Experimental Investigation
Abstract: It is now crucial for engineers to enhance procedures and boost heat exchanger efficiency. Heat exchanger performance can be significantly enhanced by a variety of methods. Composite-based fins or enlarged surfaces are frequently utilized to increase the air-side heat transfer rate in a variety of heat transfer applications. Because composite materials are lightweight, highly thermally conductive, and resistant to corrosion, they were used. A composite based fin's efficiency is influenced …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 238–251 Read article
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Measuring Tree Diversity of Sitaram Peth Village of Bhadravati Taluka of Chandrapur District by Applying Whittaker’s Additive Model
Abstract: Forest plays a major role for sustaining biodiversity and various ecological services. There are 12 tribal districts in the Maharashtra state, which holds about 60 percent of total forest cover of the state. And among these tribal districts, Chandrapur and Gadchiroli together shares about 46 percent of forest cover. For the better conservation and management practices, the tree diversity of these forest should be measured periodically. In the present study, …
Published in Research & Reviews : Journal of Ecology · Vol. 14, Issue 2, 2025 · pp. 49–54 Read article
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Optimization of Fly Ash and Granulated Blast Furnace Slag (FA-GBFS) Mixes for Flexible Pavements
Abstract: This study investigates the compaction, strength, and permeability characteristics of fly ash (FA) stabilized with granulated blast furnace slag (GBFS) to determine the optimal mix proportions for geotechnical applications. Standard Proctor compaction, unconfined compressive strength (UCS), California Bearing Ratio (CBR), and permeability tests were conducted on FA-GBFS mixtures, with GBFS content varying from 10 to 50% by dry weight. The results indicate that increasing GBFS content enhances the maximum dry …
Published in Journal of Geotechnical Engineering · Vol. 12, Issue 2, 2025 · pp. 14–19 Read article
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Lifestyle Factors and Perceptions of Diabetes Among Individuals in North India
Abstract: Background: Diabetes mellitus is influenced by a complex interplay of genetic, environmental, and lifestyle factors. In North India, unique socio-cultural and dietary patterns shape individual behaviors and perceptions toward diabetes. Understanding these lifestyle choices and cultural beliefs is critical for designing interventions that improve adherence to medical treatment and promote healthier outcomes.Methods: A cross-sectional survey was conducted among 1,500 individuals diagnosed with diabetes across selected urban and rural districts in …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 2, 2025 · pp. 1–7 Read article
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Use of Alccofine and Porcelain Waste Aggregate in Concrete Composite for Strength Enhancement
Abstract: Building construction applications benefit from recent studies on alumino-silicate alkaline activation geo-polymers and their supplementary modifier alccofine as well as new process advancements characteristics including flexural strength and split tensile strength determine structural performance and durability. The construction sector utilizes supplementary cementitious materials, waste materials, and Geo Polymer Concrete (GPC) for concrete composites because it requires environmental sustainability along with better functionality and longer service life of concrete structures. This …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 23–33 Read article
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Mechanical Characteristic Analysis of Five-Layer Carbon-Carbon Composite Material
Abstract: The current study investigates the fabrication and mechanical strength of five-layer carbon-carbon composite. The strong five-layer carbon-carbon composite material with high strength and modulus is made of a raw material called precursors. The polyacrylonitrile (PAN) method is used in the fabrication of carbon fiber. The characteristics of the resulting carbon material depend on the composition and structure of the precursor. A sheet of 50 x 40 cm five-layer carbon-carbon composite …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 405–417 Read article
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Synthesis, Molecular Docking and Biological Evaluation of Novel Chlorobenzenesulfonamide Analogues of Ibuprofen as Anti-Bacterial, Anti-Diabetic and Anti-Alzheimer Agents
Abstract: In this work, we have synthesized novel chlorobenzensulfonamide tertiary amide based analogues of Ibuprofen (Ibu) and investigated them for their anti-bacterial, anti-diabetic and anti-Alzheimer activities. In the first step, Ibu was converted to amide derivatives by incorporating different aromatic amines. These were further converted into sulfonamide analogues (Sul-Ibu, 1-9) by treating it with p-chlorobenzensulfonyl chloride. Sul-Ibu (1-9) were screened against S. aureus, B. subtilis, S. mutans, E. coli, P. aeruginosa, …
Published in International Journal of AgroChemistry · Vol. 3, Issue 1, 2025 · pp. 35–49 Read article
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Evaluation of Mechanical Properties of Terminalia Chebula and Teak Wood Sawdust Reinforced Polymer Hybrid Composites
Abstract: This study examines the mechanical characteristics of polymer hybrid composites augmented with sawdust from teak wood and Terminalia chebula (Kadukkai). To examine their effects on mechanical performance, the composites were made with different percentages of biofiller (10%, 20%, 30%, 40%, and 50%) while keeping the proportions of the two reinforcements same. Tensile, flexural, and impact tests were performed to assess their strength properties. The findings showed that flexural strength varied …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 469–476 Read article
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Association between Diabetes Type and Family History of Diabetes: A Cross-Sectional Analysis of Gender Differences and Genetic Influences
Abstract: Introduction: Diabetes mellitus DM is one of the fast-growing chronic metabolic disorder in the world, with high impact and burden in low- and middle-income country. Although genetic predisposition is a central determinant of diabetes risk, particularly for Type 2 diabetes (T2D), the contribution of familial aggregation varies across populations. In many parts of the world where diabetes is rising very fast understanding the relationship between diabetes type and family history …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 43–50 Read article
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Polymer–Gel Composite Phase Change Materials: A Functional Polymer Composite Approach for Solar-Thermal Energy Storage in Building Facades
Abstract: This study investigates polymer–composite phase change materials (PCMs) in the form of polymer–gel hybrids as multifunctional systems for solar–thermal energy storage in building façades. Paraffin- and PEG-based PCMs were embedded into polyurethane and acrylic gel matrices to create shape-stabilized polymer–composites with high PCM loading (70–80 wt%). Differential Scanning Calorimetry (DSC) confirmed distinct melting/freezing transitions at ~56°C (paraffin) and ~42°C (PEG), with enthalpy values of 120–150 J/g, closely matching theoretical predictions, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 36–51 Read article
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A Literature Survey on Biological Activities of Thiazolidine Derivatives
Abstract: Hetercyclic compounds play a vital role in both chemical and life sciences. Among them ,thiazolidinone represent a significant class, characterized by a five- membered saturated ring containing both sulfur and nitrogen atoms. Structurally, thiazolidinones are derived from thiazole, with sulfur position at the 1-position, nitrogen at the 3-position , and a carbonyl group typically located at the 2-, 4-, or 5- position are possible, though structural and functional diversity is …
Published in International Journal of Cheminformatics · Vol. 3, Issue 2, 2025 · pp. 16–21 Read article
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Investigation of Mechanical and Thermal Behavior of Glass Fiber–Enhanced PEEK Parts Produced via Fused Filament Fabrication
Abstract: This study investigates the thermal and mechanical properties of Polyetheretherketone (PEEK) polymer and Glass Fiber (GF) reinforced PEEK polymer fabricated using the Fused Filament Fabrication (FFF) process. Specimens were printed in three building orientations—X, Y, and 45°—to evaluate the influence of layer deposition on polymer material performance. Tensile and flexural tests revealed that GF-PEEK polymer exhibited significantly higher Ultimate Tensile Strength (110 MPa in X-orientation), Young's Modulus (4.5 GPa), and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 65–78 Read article
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Mid-Year Epidemiological Profile of COVID-19 Posi ve Cases in Rajasthan, India
Abstract: Background: COVID-19, caused by SARS-CoV-2, has posed persistent public health challenges globally since its emergence in late 2019. India, through enhanced surveillance and vaccina on, has seen a progressive decline in case burden. Despite improvements, localized surges and emerging variants necessitate con nuous monitoring. Rajasthan, with its urban-rural health dispari es, experienced a modest resurgence of cases in early 2025, raising concerns about exis ng immunity gaps and health system …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 3, 2025 Read article