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35 articles for “anti-inflammatory compounds”
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Design, Synthesis, and Spectroscopic Elucidation of 3-Methyl-1-Phenylpyrazol-5-One: A Cheminformatics-Aided Approach to Heterocyclic Drug Scaffolds
Abstract: Pyrazolone, a notable heterocyclic compound, has drawn increasing interest due to its broad pharmacological profile and structural versatility. The synthesis, characterisation, and biological assessment of new pyrazolone derivatives are examined in this work. A comprehensive review of existing synthetic strategies is presented, emphasizing green and efficient methodologies. Novel derivatives were synthesized using varied starting materials and catalytic systems, followed by structural confirmation through spectroscopic analyses, including NMR, IR, and mass …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 29–40 Read article
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Multi-Target Molecular Docking of Anantmul (Hemidesmus indicus) Compounds for Tay-Sachs Disease Treatment
Abstract: This research aimed to study the effects of the plant Anantmul (Hemidesmus indicus) in the treatment of Tay-Sachs disease using molecular docking studies. Tay-Sachs disease is a neurodegenerative autosomal recessive disorder caused due to accumulation of the molecule GM2 ganglioside which is caused due to lack of enzyme Beta Hexosaminidase which breaks down GM2 Ganglioside. Anantmul (Hemidesmus indicus) is a an ayurvedic plant used in the Indian subcontinent that has …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 2, 2024 · pp. 61–69 Read article
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A Review on Phytochemistry and Pharmacology of Macaranga peltata
Abstract: Macaranga peltata, categorized within the Euphorbiaceae family, represents a prevalent pioneer arboreal species across Southeast Asia, specifically in regions such as India and Sri Lanka. This review scrutinizes the phytochemical properties and pharmacological profiles of Macaranga peltata, underscoring both its historical medicinal applications and prospective therapeutic roles. The plant exhibits a rich composition of secondary metabolites, encompassing flavonoids, stilbenes, tannins, and terpenes, with the majority of these compounds being extracted …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 50–59 Read article
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Heterocyclic Substituted Flavones: Bridging Natural Products and Medicinal Chemistry
Abstract: Heterocyclic substituted flavones represent a unique and promising class of flavonoid derivatives, gaining significant attention in recent years due to their diverse and enhanced biological activities. These compounds are characterized by the incorporation of heterocyclic moieties such as quinoline, pyridine, thiazole, imidazole, oxazole, and pyrazole into the flavone structure, which significantly alters and often enhances their bioactive properties. This structural modification has made heterocyclic flavones particularly appealing as candidates for …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 23–30 Read article
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In silico analysis of Abrus precatorius L. as a potential agonist of PPARγ : A novel approach to the treatment of diabetes
Abstract: Diabetes mellitus is a chronic disorder that is characterized by a lack of insulin secretion by the pancreas or a defect in insulin action, or both. If diabetes is not controlled, over time it can cause damage to blood vessels and nerves, leading to life-threatening complications such as, kidney damage, heart disease and vision impairment. It can also weaken the immune system, making patients more prone to infection. Although treatments …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 Read article
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Comparative Analysis of Bioactive Phytochemical Profiles of Moringa Oleifera and Aegle Marmelos Grown in Bundelkhand
Abstract: A comparative analysis of the bioactive phytochemical profiles of Moringa oleifera and Aegle marmelos grown in the Bundelkhand region was conducted to explore their potential health benefits. These properties make healing plants valuable in herbal medicine, supporting various aspects of health and well-being. The study aimed to determine the differences in the concentrations of bioactive compounds such as phenolic, flavonoids, alkaloids, and vitamins C and E in the leaves and …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 14–24 Read article
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Exploring Antimalarial Activity of Chalcone Derivatives through QSAR
Abstract: Background: The core structure of chalcones contains a reactive α,β-unsaturated system within the aromatic rings, which plays a key role in mediating various biological effects. These effects include enzyme inhibition, anticancer activity, anti-inflammatory properties, as well as antibacterial, antifungal, antimalarial, antiprotozoal, and anti-filarial actions.Modifying the structure by introducing substituent groups to the aromatic ring can enhance potency, reduce toxicity, and expand their range of pharmacological actions. Methods: A total of …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 1–6 Read article
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Flaxseed-Based Drug Delivery Systems: Advancing Colon Cancer Treatment
Abstract: Flaxseed (Linum usitatissimum) has long been appreciated for its rich nutritional profile, including essential fatty acids (such as α-linolenic acid), plant fibers, and lignans. Recent research has focused on its potential as a novel drug delivery system (DDS) for the treatment of colon cancer. This review explores the bioactive constituents of flaxseed, their pharmacological activities, and innovative approaches to the use of flaxseed extracts in drug delivery for the treatment …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 54–59 Read article
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A Factualistic Study of Phytomedicinal Activity of Curcuma longa (Haldi): Plant That Infuses Life
Abstract: Curcuma longa, commonly known as turmeric, is a plant of remarkable medicinal significance that has been utilized for centuries in traditional medicine and has garnered considerable attention in modern scientific research. This review explores its extensive phytomedicinal potential, focusing on the plant's bioactive compounds, particularly curcumin, which is recognized as the primary agent responsible for its therapeutic properties. Turmeric contains an array of chemical constituents, including curcuminoids, volatile oils, and …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 14–24 Read article
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Anticancer Potential and Other Therapeutic Activities of Curcumin & Its Derivatives
Abstract: Curcumin, a compound isolated from turmeric, is used in the management of various diseases due to its extensive medicinal properties. Curcumin, the principal polyphenol isolated from Curcuma longa (turmeric), has garnered immense scientific interest for its extensive medicinal properties, including potent anti-inflammatory, antioxidant, and anticancer activities demonstrated in preclinical models. An expanding body of research indicates broad therapeutic promise in managing diverse pathologies, from various cancers to chronic inflammatory, metabolic, …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 19–28 Read article
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Postbiotics Unveiled: Mechanistic Insights and Therapeutic Implications in Obesity.
Abstract: The burgeoning global obesity epidemic necessitates innovative therapeutic approaches, and postbiotics, bioactive compounds arising from microbial fermentation, have emerged as promising contenders in reshaping obesity management. This comprehensive review explores the multifaceted mechanisms by which postbiotics impact obesity, from modulating gut microbiota composition to influencing metabolic pathways and enhancing energy expenditure. The exploration of postbiotics is rooted in a deeper understanding of the gut–brain axis and bidirectional communication between gut …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 11–28 Read article
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Cannabinoids as Nutritional Supplements: Exploring The Potential Health Benefits and Regulatory Landscape
Abstract: Cannabinoids, the bioactive compounds derived from the Cannabis sativa plant, have garnered increasing interest for their potential role as nutritional supplements. This abstract provides a succinct overview of cannabinoids as nutritional supplements. This review delves into the multifaceted aspects of cannabinoids, particularly their interaction with the endocannabinoid system (ECS) and their potential health benefits. The exploration begins by elucidating the intricate relationship between cannabinoids and the ECS, a vital regulatory …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 48–53 Read article
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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In-Silico Studies of Phytochemicals from Allium sativum with H5N1 Protein in Avian Influenza
Abstract: Allium sativum or garlic is a medicinal plant that is reported for its applications in many biological activities, such as its antiviral, antidiabetic, and anti-inflammatory properties, etc. In this paper, the focus has been the identification of potential phytochemicals that can be extracted from Allium sativum that can act as a candidate for drug formation that possesses the capability to inhibit the H5N1 Avian Influenza, a type of highly pathogenic …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 2, 2024 · pp. 50–60 Read article
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A Review on the Magical Plant : Shatavari (Asparagus racemosus)
Abstract: Shatavari (Asparagus racemosus) is a revered medicinal herb in Ayurveda, recognized for its diverse health benefits, particularly for women’s health. The chemical makeup, pharmacological characteristics, and therapeutic uses of shatavari are thoroughly examined in this review. Key active compounds include saponins, flavonoids, and phytoestrogens, which contribute to its adaptogenic, antioxidant, and hormone-regulating effects. These properties make Shatavari effective in addressing female reproductive issues, such as infertility, irregular menstrual cycles, and …
Published in Recent Trends in Cosmetics · Vol. 2, Issue 1, 2025 · pp. 32–43 Read article