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Research and Reviews : A Journal of Biotechnology Review Article

Pharmacokinetic and Pharmacodynamic Studies of Black Seed Derived Compound

  1. Mohd. Wasiullah Department of Pharmacy, Prasad Institute of Technology, Jaunpur
  2. Piyush Yadav Department of Pharmacy, Prasad Institute of Technology, Jaunpur
  3. Pooja Yadav Department of Pharmacy, Prasad Institute of Technology, Jaunpur
  4. Neha Kumari Department of Pharmacy, Prasad Institute of Technology, Jaunpur

Abstract

Black seed (Nigella sativa) has been celebrated for centuries for its remarkable therapeutic properties. Among its bioactive compounds, thymoquinone (TQ) has gained significant attention in pharmacological research due to its diverse health benefits. This review delves into the pharmacokinetic (PK) and pharmacodynamic (PD) properties of black seed compounds, with a particular emphasis on TQ, the most extensively studied component. The PK of TQ includes the parameters of absorption, distribution, metabolism, and excretion (ADME), which determine how the compound behaves within the body. Understanding these factors is crucial to optimizing its therapeutic potential. On the pharmacodynamic front, TQ exhibits mechanisms of action, such as antioxidant, anti-inflammatory, and anticancer effects, making it a promising candidate for drug development. Additionally, clinical studies on black seed derivatives have shown encouraging results in managing various diseases, including inflammation, diabetes, cardiovascular disorders, and cancer. These findings highlight the immense potential of black seed compounds in modern medicine. By exploring the therapeutic benefits and mechanisms of action of TQ and other bioactives, this review aims to provide a comprehensive understanding of black seed’s role in promoting health and combating disease, paving the way for its integration into clinical applications

Keywords

References (25)

  1. Zakarial Ansar FH, Latifah SY, Wan Kamal WHB, Khong KC, Ng Y, Foong JN, et al. Pharmacokinetics and biodistribution of thymoquinone-loaded nanostructured lipid carrier after oral and intravenous administration into rats. Int J Nanomedicine. 2020;15:7703–7717. doi:10.2147/IJN.
  2. Ahmad A, Khan RM, Alkharfy KM, Raish M, Al-Jenoobi FI, Al-Mohizea AM. Effects of thymoquinone on the pharmacokinetics and pharmacodynamics of glibenclamide in a rat model. Nat Prod Commun. 2015;10(8):1395–1398.
  3. Ashrafizadeh M, Zarrabi A, Hashemi F, Zabolian A, Saleki H, Bagherian M, et al. Polychemotherapy with curcumin and doxorubicin via biological nanoplatforms: Enhancing antitumor activity. Pharmaceutics. 2020;12(11):1084.
  4. Kanter M, Demir H, Karakaya M, Özbek H. The elimination and pharmacokinetics of thymoquinone in rats. J Ethnopharmacol. 2012;141(2):700–705.
  5. El Gazzar MA. Thymoquinone suppressses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation. Inflammation Research. 2007;56(8):345-351. doi:10.1007/s00011-007-7051-0
  6. Asaduzzaman Khan M, Tania M, Fu S, Fu J. Thymoquinone, as an anticancer molecule: From basic research to clinical investigation. Oncotarget. 2017;8(31):51907–51919. doi: 10.18632.
  7. Farkhondeh T, Samarghandian S, Shahri AMP, Samini F. The Neuroprotective Effects of Thymoquinone: A Review. Dose-Response. 2018;16(2). doi:10.1177/1559325818761455
  8. Kouidhi B, Zmantar T, Jrah H, Souiden Y, Chaieb K, Mahdouani K, et al. Antibacterial and resistance-modifying activities of thymoquinone against oral pathogens. Annals of Clinical Microbiology and Antimicrobials. 2011;10(1):29. doi:10.1186/1476-0711-10-29
  9. Pal RR, Rajpal V, Singh P, Saraf SA. Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis. Pharmaceutics. 2021;13(6):775. doi:10.3390/pharmaceutics13060775
  10. Abd El-Hack ME, Alagawany M, Farag MR, Tiwari R, Karthik K, Dhama K. Nutritional, healthical and therapeutic efficacy of black cumin (Nigella sativa) in animals, poultry and humans. Int J Pharmacol. 2016;12(3):232–248.
  11. Shahrajabian MH, Sun W. Importance of Thymoquinone, Sulforaphane, Phloretin, and Epigallocatechin and their Health Benefits. Letters in Drug Design & Discovery. 2024;21(2):209-225. doi:10.2174/1570180819666220902115521
  12. Iqbal S, Javeed A, Sattar A, Tanvir R. Pharmacokinetics of thymoquinone in layer chickens following oral and intravenous administration. Journal of Veterinary Pharmacology and Therapeutics. 2019;42(6):707-712. doi:10.1111/jvp.12810
  13. Taysi S, Algburi FS, Mohammed ZR, Ali OA, Taysi ME. Thymoquinone: A review on its pharmacological importance, and its association with oxidative stress, COVID-19, and radiotherapy. Mini Rev Med Chem. 2022;22(14):1847–1875. doi:10.2174/13895575226
  14. Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytotherapy Research. 2003;17(4):299-305. doi:10.1002/ptr.1309
  15. Lin CH, Hsieh CL. Chinese Herbal Medicine for Treating Epilepsy. Frontiers in Neuroscience. 2021;15. doi:10.3389/fnins.2021.682821
  16. Kurowska N, Madej M, Strzalka-Mrozik B. Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer. Current Issues in Molecular Biology. 2023;46(1):121-139. doi:10.3390/cimb46010010
  17. Alhmied F, Alammar A, Alsultan B, Alshehri M, Pottoo FH. Molecular Mechanisms of Thymoquinone as Anticancer Agent. Combinatorial Chemistry & High Throughput Screening. 2021;24(10):1644-1653. doi:10.2174/1386207323999201027225305
  18. Tabassum S, Rosli N, Ichwan SJA, Mishra P. Thymoquinone and its pharmacological perspective: A review. Pharmacological Research - Modern Chinese Medicine. 2021;1:100020. doi:10.1016/j.prmcm.2021.100020
  19. Adinew GM, Messeha SS, Taka E, Badisa RB, Soliman KFA. Anticancer Effects of Thymoquinone through the Antioxidant Activity, Upregulation of Nrf2, and Downregulation of PD-L1 in Triple-Negative Breast Cancer Cells. Nutrients. 2022;14(22):4787. doi:10.3390/nu14224787
  20. Kokoska L, Havlik J, Valterova I, Sovova H, Sajfrtova M, Jankovska I. Comparison of Chemical Composition and Antibacterial Activity of Nigella sativa Seed Essential Oils Obtained by Different Extraction Methods. Journal of Food Protection. 2008;71(12):2475-2480. doi:10.4315/0362-028x-71.12.2475
  21. Jrah Harzallah H, Grayaa R, Kharoubi W, Maaloul A, Hammami M, Mahjoub T. Thymoquinone, theNigella sativaBioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis. Oxidative Medicine and Cellular Longevity. 2012;2012:1-6. doi:10.1155/2012/854065
  22. Akram Khan M, Afzal M. Chemical composition of Nigella sativa Linn: Part 2 Recent advances. Inflammopharmacology. 2016;24(2-3):67-79. doi:10.1007/s10787-016-0262-7
  23. Khader M, Eckl PM. Thymoquinone: An emerging natural drug with a wide range of medical applications. Iran J Basic Med Sci. 2014;17(12):950–957
  24. Banerjee S, Padhye S, Azmi A, Wang Z, Philip PA, Kucuk O, et al. Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer. Nutrition and Cancer. 2010;62(7):938-946. doi:10.1080/01635581.2010.509832
  25. Isaev NK, Chetverikov NS, Stelmashook EV, Genrikhs EE, Khaspekov LG, Illarioshkin SN. Thymoquinone as a Potential Neuroprotector in Acute and Chronic Forms of Cerebral Pathology. Biochemistry (Moscow). 2020;85(2):167-176. doi:10.1134/s0006297920020042
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