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Research & Reviews: A Journal of Drug Formulation, Development and Production Original Research

Design, Synthesis, and Evaluation of Novel Quinazoline Derivatives as Anti-Inflammatory Agents

  1. Pankaj Chaturvedi Departmen of Pharmaceutical Chemistry, Advance Institute of Biotech and Paramedical Sciences, Kanpur
  2. Abhinav Prasoon Mishra Departmen of Pharmaceutical Chemistry, Chandra Shekhar Singh College of Pharmacy, Koilaha, Kaushambi
  3. Vivek Dwivedi Departmen of Pharmaceutical Chemistry, Chandra Shekhar Singh College of Pharmacy, Koilaha, Kaushambi
  4. Saif Mohammed Saleh Ansari Department of Laboratory Animal Facility, Sam Higginbottom University of Agriculture, Technology & Sciences, Prayagraj

Abstract

Novel quinazoline derivatives are well-known heterocyclic scaffolds that are renowned for having a wide range of biological functions. A new quinazoline derivative was synthesized from anthranilic acid through a multi-step sequence involving amide formation, cyclization, and aromatic group substitution. The structure of the methoxy- and chloro-substituted final compound was confirmed by IR and 1H NMR spectroscopy. Evaluation of synthesized molecules anti-inflammatory activity using paw edema caused by carrageenan paradigm in Wistar rats demonstrated a significant reduction in edema, with efficacy comparable to the conventional drug diclofenac sodium. We propose that the enhanced activity stems from the electron-donating and withdrawing substituents, which may improve receptor binding and the overall pharmacodynamics profile. These findings position this quinazoline derivative could be potential alternative for new anti-inflammatory agents.

Keywords

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