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Research & Reviews: A Journal of Drug Design & Discovery Review Article

Protective Effects Of Curcumin Against Osteoporosis And Its Molecular Mechanism

  1. Chhatrapalsinh R. Parmar Department of Pharmacognosy, Ahinsa Institute of Pharmacy
  2. Pratiksha N. Patil Department of Pharmacognosy, Ahinsa Institute of Pharmacy
  3. Riddhi S.Bhavsar Department of Pharmacognosy, Ahinsa Institute of Pharmacy
  4. Rohitkumar D.Shah Department of Pharmacognosy, Ahinsa Institute of Pharmacy
  5. Riya A.Rajput Department of Pharmacognosy, Ahinsa Institute of Pharmacy

Abstract

One of the most prevalent metabolic disorders is osteoporosis (OP), which primarily affects postmenopausal women and the elderly. It is often associated with gradual loss of bone density, ongoing destruction of bone microstructure, and increased risk of osteoporosis. Pharmacotherapy is the primary approach for treating and preventing osteoporosis. However, persistent medication therapy invariably results in drug responses and particular adverse effects. Therefore, scientists continue to search for new monomeric compounds from natural plants. Curcumin (CUR), a drug candidate for the treatment of osteoporosis, is a natural phenolic compound with various pharmacological and biological activities such as antioxidant, antiapoptotic, and anti-inflammatory. This connection has been studied for the maintenance of bone health in various models of osteoporosis. We go over preclinical and clinical research on curcumin’s ability to prevent and treat osteoporosis. These results suggest that, if rigorous clinical and clinical studies are conducted, curcumin could be used as a supplement and other medications to heal bones by targeting the standard layers of the osteoporosis process. In addition to providing information for future study and development of curcumin, this article discusses the mechanism of action and therapeutic potential of curcumin in preventing and treating osteoporosis. Contents: The medication curcumin has a wide range of chemical and biological effects.

Keywords

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