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Research and Reviews: A Journal of Pharmaceutical Science Review Article

A Comprehensive Review on Coumarin Derivatives

  1. Sasikumar S Department of Pharmacy, Surya College of Pharmacy, Villupuram Dt
  2. Silambarasan S Department of Pharmacy, Surya College of Pharmacy, Villupuram Dt
  3. Vijaiyalakshmi R Department of Pharmaceutical Sciences, Surya College of Pharmacy, Villupuram Dt
  4. Anbazhagan S Department of Pharmaceutical Sciences, Surya College of Pharmacy, Villupuram Dt

Abstract

Coumarins are naturally occurring compounds found in plants, fungi, and microorganisms with diverse bioactivities. They have antithrombotic, anti-inflammatory, antioxidant, antimicrobial, antiviral, anticancer, and neuroprotective properties. Extracting coumarins, using methods like maceration and microwave- assisted extraction, is crucial for their applications. However, safety and toxicology are important, especially in pharmaceuticals, cosmetics, and food additives. Consuming moderate amounts of coumarin-rich foods is generally safe, but excessive intake raises concerns about hepatotoxicity and photosensitivity. Specific coumarin derivatives, like warfarin, require precise dosing and monitoring to prevent bleeding complications. The safety and toxicity profiles of coumarins depend on factors like compound type, dosage, and individual susceptibility.

Keywords

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