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171 articles for “Drug release study”
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Development and Characterization of Bifonazole Nitrate Nanosuspension Loaded Topical Gel
Abstract: Objective: The goal of the present study was to formulate and evaluate nanosuspension-based topical delivery system of bifonazole nitrate (BN) or increased saturation solubility and controlled drug release. Methods: BN nanosuspension was prepared by pearl milling technique using zirconium oxide beads as a milling media, poloxamer 407 as a stabilizer and glycerol as wetting agent. Effect of various process parameters such as, stirring time and poloxamer concentration were optimized. The …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 9, Issue 2, 2018 · pp. 36–48 Read article
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Fabrication and Characterization of Diacerein Loaded Nanosponge for Topical Delivery
Abstract: Diacerein, an anti-inflammatory drug, which comes under BCS class II, commonly used in treatment of osteoarthritis has limited by its poor solubility and bioavailability when administered topically. This study aimed to develop and evaluate diacerein-loaded nanosponges gel using varying concentrations of ethyl cellulose and polyvinyl alcohol (PVA) to enhance its delivery. Nanosponges were prepared using an emulsion solvent evaporation technique, with different ratios of ethyl cellulose (0.05-0.250%) and PVA (0.2-0.3%). …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 26–46 Read article
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Chitosan-based Polymer Composites for Antibacterial and Antiviral Drug Applications
Abstract: The natural substance chitosan is made from chitin. It is used a lot in medicine because it is safe for the body, breaks down naturally, and kills germs. To find out how chitosan-based polymer mixes could be used to make drugs that kill germs and viruses, this study looks into them. By reacting with the cell walls of bacteria, chitosan has been shown to kill bacteria and stop viruses from …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 609–620 Read article
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Effect of Glycemic Control on Sputum Conversion at the End of Intensive Phase of Category I DOTS Therapy among Patients with Pulmonary Tuberculosis
Abstract: India is an endemic country of tuberculosis and diabetic capital of the world. A patient with diabetes has more chance of occurrence tuberculosis. Many studies pointed out the merging epidemic of diabetes and tuberculosis. Rifampicin and Isoniazid are the most prominent drugs in anti-TB treatment. These drugs disrupt the metabolism of many anti-hypoglycemic agents and lower the plasma levels, leading to hypogycemia. In non-diabetics, it impairs the release and action …
Published in Journal of Nursing Science & Practice · Vol. 10, Issue 1, 2020 · pp. 13–17 Read article
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Isolation and Characterization of Glucuronide Compound from Luffa Tuberosa (Roxb.) for Potential Applications in Polymer Chemistry
Abstract: This study explores the isolation process of glucuronide compounds from Luffa tuberosa (Roxb.) using an efficient and cost-effective method. The extracted compound, Gypsogenin-3β-O-β-D-Methyl glucuronide, is characterized using spectroscopic techniques such as IR, NMR, and Mass Spectrometry. The polymeric nature of glucuronide-based compounds and their potential applications in polymer and composite materials are discussed. The findings highlight the suitability of glucuronide derivatives in biomedical, pharmaceutical, and polymeric drug delivery systems. Additionally, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 566–572 Read article
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The effective therapeutic strategies to fight against COVID-19 in India
Abstract: In December 2019, the global pandemic coronavirus infection (COVID-19) was first detected in Wuhan, Hubei Province, Central China. It is caused by coronavirus-2, which causes severe acute respiratory syndrome (SARS-CoV-2). This was declared by World Health Organization on 11th March 2020. In India, the first case of COVID-19 infection was reported in Kerala on January 27,2020 of a 20 yr old female presented to an Emergency Department in General Hospital, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 12, Issue 1, 2022 · pp. 43–49 Read article
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Fabrication and Characterization of Sustained Release Beads of Carbamazepine by Extrusion – Spheronization Containing Carbopol®974
Abstract: The erratic absorption of Carbamazepine, BCS Class II drug, due to low water solubility and anticholinergic properties can be minimized by developing sustained release beads. Sustained release beads of Carbamazepine were prepared using axial single screw extruder and a chequered plate spheronizer. Beads offer therapeutic advantages such as easy dispersion in the gastro-intestinal tract, lower risk of dose dumping, reduce peak plasma fluctuations and drug release is independent of gastric …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 2, Issue 2, 2011 · pp. 11–21 Read article
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Development and characterization of Emulgel a Novel formulation for topical drug delivery of Ofloxacin
Abstract: The aim of this work is to develop best Emulgel formulation carrying Antifungal agent Ofloxacin Emulgel has been emerged as a promising drug delivery system. Formulation of Ofloxacin Emulgel was done by using Carbopol 934 as a gelling agent, liquid paraffin as hydrophobic phase, Tween-80 and span-80 as emulsifiers and surfactant. Ofloxacin has been used in pharmaceutical formulation since it has antimicrobial activity. It acts by inhibiting bacterial DNA gyrase …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 2, 2019 · pp. 19–23 Read article
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Thermosensitive and pH-Responsive Polymers for Smart Drug Delivery Systems
Abstract: Sensitive to temperature and pH, polymers are becoming a fascinating new class of material suitable for application in drug delivery systems. These polymers can be utilised in controlled release of medications as they change form depending on temperature and acidity. Thermosensitive polymers vary their formation and breakdown behaviour with temperature variations. They are therefore perfect for delivering pharmaceuticals to individuals as heat may be utilised to activate the medications at …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 479–491 Read article
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Effectiveness of Structured Teaching Programme on Knowledge regarding Administration of Emergency Drugs to patients among Nursing Students at Selected College of Nursing
Abstract: Emergency department is an area where the nurses are encounter with many emergency and all emergencies seek attention and immediate care for life saving. Student nurses are posted in Emergency medicine, formerly known in some countries as accident and emergency medicine is the medical specialty involving care for undifferentiated and unscheduled patients with illnesses or injuries requiring immediate medical attention. In many emergency departments the nursing students are posted and …
Published in Journal of Nursing Science & Practice · Vol. 8, Issue 3, 2018 · pp. 48–50 Read article
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Design and Evaluation of Promethazine Hydrochloride Rapimelts
Abstract: Objective: In the present study, efforts were taken to develop rapimelts of promethazine HCl—an antiemetic agent with an objective to achieve rapid disintegration, and further improve thebioavailability of drug.Methods:Rapimelts were prepared by direct compression methodusing superdisintegrants such as crospovidone (cp), croscarmellose sodium (ccs), sodiumstarch glycolate (ssg). The prepared formulations were evaluated for precompressionparameters such as bulk density, tapped density, Carr’s compressibility, Hausner ratio andangle of repose. The prepared batches of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 1, 2019 · pp. 11–19 Read article
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Development of Biodegradable Poly (Lactic-Co-Glycolic Acid) (PLGA) Nanoparticles for Sustained Release of Insulin
Abstract: This research outlines the creation of biodegradable composite nanoparticles made from poly (lactic-co-glycolic acid) (PLGA) designed for the sustained release of insulin. The emphasis is on the interactions between the polymer and the drug at the interface, along with the dynamics of the release matrix. The in vitro release kinetics, surface morphology, encapsulation efficiency, particle size, and polydispersity of insulin-loaded PLGA nanoparticles were analyzed following their production via a double …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1690–1699 Read article
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Advanced Ointment Formulation: An Insightful Review of Innovation and Efficacy
Abstract: This review provides an in-depth exploration of the evolution of ointment formulations, particularly considering the increasing prevalence of fungal infections and the growing demand for effective antifungal treatments. Traditional ointment formulations, while useful, often face significant challenges, such as inadequate penetration into the skin, poor bioavailability, and undesirable textures that limit their efficacy. As a result, there has been a shift toward more advanced, innovative formulations that aim to address …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 1, 2025 · pp. 14–23 Read article
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Cryptosomes: An Emerging and One of the Most Promising Drug Delivery System
Abstract: Vesicular drug delivery systems provide a potential solution to the issues of medicines with low bioavailability and quick removal from the body. The solid-lipid particulate system, emulsion-based system, solid lipid tablet, and vesicular system are the four types of lipid-based drug delivery methods. Cryptosomes are a new vesicular drug delivery method that may address the drawbacks of traditional drug delivery systems, such as high stability, improved bioavailability, prolonged-release, and reduced …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 3, 2023 · pp. 9–15 Read article
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Development, Optimization and Evaluation of Polyherbal Gel Comprising of Azadirachta Indica, Calendula Officenalis, Turmeric and Aloe-vera for Treatment of Wound
Abstract: Azadirachta indica, Calendula officinalis, Turmeric (Curcuma longa), and Aloe-vera are known to possess numerous medicinal properties. These herbs have been traditionally used across various cultures for the treatment of a wide range of ailments due to their potent therapeutic effects. Individually, they have demonstrated efficacy in addressing conditions such as acne, diabetes, wound healing, gastric ulcers, first-degree burns, psoriasis, arthritis, and pneumonia. Additionally, they are known for their antimicrobial, anti-inflammatory, …
Published in Recent Trends in Cosmetics · Vol. 2, Issue 2, 2025 · pp. 41–53 Read article
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A Review on Drug Delivery Systems Using Microfluidics
Abstract: AbstractMicrofluidics is undoubtedly an influential technology that is currently revolutionizing the chemical and biological studies by replicating laboratory benchtop technology on a miniature chip-scale device. In the area of drug delivery science, microfluidics offers advantages, such as accurate dosage, ideal delivery, target-precise delivery, sustainable and controlled release, several dosing, and slight side effects. These helps bring significant assets to the drug delivery systems. Microfluidic technology has been increasingly used for …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 10, Issue 1, 2020 · pp. 1–10 Read article
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Formulating Self Phospholipids Dispersion of Poorly Water-Soluble Drug to Enhance Oral Bioavailability
Abstract: In present study, self-nano phospholipid dispersion (SNPD) of Simvastatin (SIM) was prepared based on Phosal 53 MCT to improve the oral bioavailability. Ternary phase diagrams were constructed to evaluate the efficient nanoemulsion regions and also for the optimum concentrations of lipid (Phosal 53 MCT) and surfactant (Cremophore RH 40), co-surfactant (Gelucire 50/13) and water in the formulation. The globule size of SNPD batch A was found to be 115.7 nm, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 3, 2019 · pp. 24–33 Read article
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Formulation and In vitro Evaluation of Oral Fast Dissolving Tablets of A Novel Antidepressant Drug by Using Camphor As A Subliming Agent
Abstract: The purpose of the present investigation is to formulate fast dissolving tablets of Venlafaxine HCl, a novel antidepressant by direct compression method using camphor as subliming agent in the three different concentrations of 2%, 5% and 10%. Croscarmellose, tulsion-414 and sodium starch glycolate were used as superdisintegrants in two different concentrations of 5% and 10%. The drug-excipients compatability was ruled out through FTIR studies. A total of six formulations were …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 3, 2015 · pp. 12–18 Read article
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Floating In-Situ Gel for Gastric Retention Delivery
Abstract: When taken orally, medications with a limited window of absorption in the gastrointestinal tract (GIT) are typically accessible to the extremities due to the partial release of the active component and the brief residence period at the absorption site. Because they prolong the duration of the drug's presence in the stomach, they are made with high density and have the capacity to swell. Because oral fluids go more quickly through …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 2, 2024 · pp. 24–32 Read article
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Nanomedicine in the Tumor Microenvironment: Physiological Modulation Through Tissue Engineering Approaches
Abstract: The integration of nanomedicine and tissue engineering offers transformative strategies for cancer therapy by directly modulating the physiological processes within the tumor microenvironment (TME). This review emphasizes recent advances in nanomedicine that enable precise drug delivery, controlled release, and real-time monitoring of key physiological parameters influencing tumor progression, angiogenesis, and immune evasion. Tissue-engineered 3D tumor models provide physiologically relevant platforms that better mimic in vivo conditions than traditional 2D cultures, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 19–31 Read article