Development and Characterization of Bifonazole Nitrate Nanosuspension Loaded Topical Gel

Arun Raj R.; Anjitha P K

doi:10.37591/(rrjops).v9i2.76

Abstract

Objective: The goal of the present study was to formulate and evaluate nanosuspension-based topical delivery system of bifonazole nitrate (BN) or increased saturation solubility and controlled drug release. Methods: BN nanosuspension was prepared by pearl milling technique using zirconium oxide beads as a milling media, poloxamer 407 as a stabilizer and glycerol as wetting agent. Effect of various process parameters such as, stirring time and poloxamer concentration were optimized. The optimized nanosuspension was lyophilized using mannitol as a cryoprotectant and incorporated into a topical gel using Carbopol 934P as a gelling agent for controlling the drug release. Results: The percentage drug entrapment results showed that entrapment efficiency increases with increase in the surfactant concentration and drug loading decreases with increase in stirring speed. The drug release increased with increase in the surfactant concentration with high rotation speed. Percentage entrapment efficiency and in vitro drug release of optimized formulation was found to be 93.48% and 79.93%, respectively. Prepared gel was clear and showed good homogeneity and pH was found in normal range. The drug release from Bifonazole nanosuspension loaded gel was significantly prolonged by using the gelling system due to the addition of the polymer carbopol 934P and the mechanism of drug release was non-Fickian and it follows Higuchi matrix. Conclusion: BN nanosuspension loaded topical gel showed increased saturation solubility and controlled drug release and consequently avoids its side effects such as burning and itching. Keywords: Bifonazole nitrate (BN), nanosuspension, topical gel, factorial design, design expert softwareCite this ArticleArun RR, Anjitha PK. Development and Characterization of Bifonazole Nitrate Nanosuspension Loaded Topical Gel. Research and Reviews: A Journal of Pharmaceutical Science. 2018; 9(2): 36–48p.