10 publications
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Comparative Evaluation of Corneal Permeation of Indomethacin Using Different Vegetable OilBy Arun Raj R., Lorain Mary Jose
Abstract: Topical administration of drugs is the most favoured route for management of ocular inflammation. About 90% of dose applied topically from such solutions is lost due to precorneal losses (nasolacrimal drainage) and tearing results in poor availability as contact time is less between drug and ocular tissue. An increased ocular contact time of the drug may be achieved by formulating the drug as an oil solution. In this study, invitro …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 2, 2025 · pp. 7–12 Read article →
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Formulation and Evaluation of Curcumin Loaded Transferosomal Nasal In-Situ Gel for Alzheimer’s DiseaseBy Arun Raj R., Arsha Murali
Abstract: Objective: To develop a novel delivery of curcumin by formulating its transfersome into nasal in situ gel. Methods: Curcumin transfersomes were prepared by thin film hydration method. Optimization of the formulation was performed using Design Expert software. Formulation and characterization of optimized batch of curcumin transfersomes were performed. The nasal in situ gel was prepared by incorporating the optimized transfersome. Results: The pH, drug content, in-vitro drug release profile and …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 19–31 Read article →
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Development and Characterization of 5-Fluorouracil Cubosomal Nanosponge Tablet for Colon TargetingBy Arun Raj R., Steffy Thomas
Abstract: The objective of this study was to develop nano-scale delivery system to improve nanometric size range, percentage drug entrapment efficiency, controlled release of the incorporated drug and the protection against degradation. 5-FU loaded cubosomal dispersion was prepared by the bottom up technique and formulation was characterized. From this, 5-FU cubosomal nanosponges were prepared by the emulsion solvent diffusion method using various pH dependent polymers and evaluated, encapsulation of this formulation …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 2, 2019 · pp. 9–18 Read article →
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Development and Characterization of Ion-Activated Ocular in situ Gel of Carbinoxamine MaleateBy Arun Raj R., Abhiram A
Abstract: AbstractObjective: To formulate and evaluate ion activated in-situ gel of carbinoxamine maleate by hot method. Methods: Ion activated in-situ gel of carbinoxamine maleate were prepared by hot method. Optimization of carbinoxamine maleate in situ gel was performed using design expert software. Formulation and characterization of optimized batch of in situ gel were performed. Results: The pH of the formulation was found to be satisfactory. The drug content was within acceptable …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 1, 2019 · pp. 28–35 Read article →
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Development and Characterization of Bifonazole Nitrate Nanosuspension Loaded Topical GelBy Arun Raj R., Anjitha P K
Abstract: Objective: The goal of the present study was to formulate and evaluate nanosuspension-based topical delivery system of bifonazole nitrate (BN) or increased saturation solubility and controlled drug release. Methods: BN nanosuspension was prepared by pearl milling technique using zirconium oxide beads as a milling media, poloxamer 407 as a stabilizer and glycerol as wetting agent. Effect of various process parameters such as, stirring time and poloxamer concentration were optimized. The …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 9, Issue 2, 2018 · pp. 36–48 Read article →
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Formulation And Evaluation of Domperidone Medicated Jelly Using Solvent Deposition Method For Solubility EnhancementBy Arun Raj R., Jibcy Feba Rachel John, Jyoti Harindran
Abstract: Objective: The purpose of this study is to develop and characterize medicated jelly of Domperidone. Domperidone is associated with poor aqueous solubility and dissolution rate and thus exhibit a poor bioavailability. Solvent deposition is a promising method to improve the solubility of poor water soluble drugs.Methods: Solvent depositions were prepared for optimization and evaluated for percentage drug content, invitro dissolution, solubility analysis. Optimization of Domperidone solvent deposition was done using …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 2, 2017 · pp. 40–53 Read article →
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Formulation and Evaluation of Transungual Drug Delivery of Fluconazole Using Permeation Enhancers Screened by Hydration of Nail PlateBy Arun Raj R., Nithin Kurian
Abstract: The objective of the work was to formulate nail lacquer containing fluconazole an antifungual drug for the treatment of onychomycosis. Onychomycosis, a common fungal nail infection affects the people. Topical and ungual therapy is limited because of the poor permeation of the drug through nail plate. Film base was prepared using varying concentration of cellulose acetate and ethyl cellulose as polymers. The permeation enhancers were screened by nail plate hydration. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 3, 2017 · pp. 32–45 Read article →
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Formulation, Optimization and Evaluation of Flurbiprofen Liposomal GelBy Arun Raj R., Nikita Sara Abraham
Abstract: The present study deals with effect of various combinations of lecithin, cholesterol, chloroform-methanol and tween-80 on liposomes of flurbiprofen. Optimization of the flurbiprofen liposomes by Design Expert software was done. Vesicle size, drug content, SEM and entrapment efficiency were evaluated. Flurbiprofen gel with optimized liposome using Carbopol 934 as gelling agents, were formulated. pH, spreadability and drug content in the gel were evaluated. Results of skin irritation study showed that …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 33–42 Read article →
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Enhancement of Bioavailability of Clopidogrel Using Different Solubility Enhancement TechniquesBy Arun Raj R., Nadiya K.K., Jyoti Harindran
Abstract: Bioavailability is the key determinant of a drug for its therapeutic effectiveness, which in turn depends upon the solubility of that drug in gastro intestinal fluid. Clopidogrel is a BCS class II drug. Drugs of this category have low solubility and high permeability, so their bioavailability is less. This can be overcome by doing pharmaceutic modifications on it. In the present study, three different modifications, namely, complexation, solvent deposition and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 2, 2016 · pp. 25–39 Read article →
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Formulation and Evaluation of Verapamil Solid Dispersion Tablets for Solubility EnhancementBy Arun Raj R., Anju C. Das, Sreerekha S., Jyoti Harindran
Abstract: This study was mainly designed to solve the drawbacks of conventional verapamil solid dosage form, low bioavailability and limited clinical efficacy, by preparing solid dispersion. Verapamil solid dispersion was developed by kneading method, melt solvent method and co-precipitation method to modify the release and enhance solubility of the drug. The physical state of the dispersed verapamil in the polymer matrix was characterized by differential scanning calorimetry, powder X-ray diffraction, scanning …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 1, 2016 · pp. 39–54 Read article →