Vesicular drug delivery systems provide a potential solution to the issues of medicines with low bioavailability and quick removal from the body. The solid-lipid particulate system, emulsion-based system, solid lipid tablet, and vesicular system are the four types of lipid-based drug delivery methods. Cryptosomes are a new vesicular drug delivery method that may address the drawbacks of traditional drug delivery systems, such as high stability, improved bioavailability, prolonged-release, and reduced elimination of quickly metabolizable medicines, among others. The term Cryptosome comes from the Greek words “Crypto”, which means concealed, and “Soma”, which means body. It is made up of distearoylphosphatidylcholine and phospholipids like distearoyl phosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG). Vesicular systems represent the use of vesicles as a carrier system or additive in many areas. This study examines different vesicular drug delivery systems and highlights cryptosome's progress in the field of drug delivery. Researchers working in the area of vesicular drug delivery will benefit from this review.
