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784 articles for “system functionality”
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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Study of Modification of Butadiene-Styrene Rubber with Biopolymer
Abstract: This paper presents a detailed study aimed at the development of a new composite system based on butadiene-styrene rubber (BSR) and natural biopolymer wooden stone. The main goal of the work was the creation of a thermodynamically compatible material with improved ozone-resistant and physical-mechanical properties, able to function effectively in aggressive conditions, especially in the liberated areas of the Republic of Azerbaijan, where the requirements for the stability of materials …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 299–310 Read article
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Design and Simulation of Low-power, High-speed Effective Area Mux Based One-bit Full Adder Using CMOS Technology
Abstract: Our findings reveal a novel kind of circuit capable of performing both XOR and XNOR operations in parallel. Power dissipation and delay are both greatly reduced in the proposed circuits due to their low output capacitance as well as minimal short-circuit power dissipation. We show six new hybrid 1-bit full-adder (FA) circuits that take use of the XOR-XNOR or XOR/XNOR gates' special full-swing function. Each potential circuit layout has both …
Published in International Journal of VLSI Circuit Design & Technology · Vol. 1, Issue 1, 2023 · pp. 25–33 Read article
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Integrating Human-Centric Principles into Machine Design: Ergonomic and Safety Enhancements in Mechanical Systems
Abstract: The integration of human-centric design (HCD) principles into mechanical systems has become increasingly critical in contemporary machine design. As machines become more complex and operate within high-interaction environments, the need for design strategies that prioritize human safety, usability, and comfort has intensified. This review explores how ergonomic insights, safety standards, and user experience (UX) considerations influence the physical configuration, control mechanisms, and operational safety of mechanical systems across industrial, healthcare, …
Published in Trends in Machine design · Vol. 12, Issue 2, 2025 · pp. 33–37 Read article
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Explainable Machine Learning Integrated with Polymer-Based Diagnostic Technologies for Liver Health Classification
Abstract: Early and reliable assessment of liver health is essential for timely treatment, yet most machine-learning approaches face limitations such as class imbalance and low clinical interpretability. This study proposes a polymer-integrated, explainable machine-learning framework that combines SMOTE-based data balancing, Logistic Regression, and XAI techniques (SHAP and LIME) for transparent liver-health classification. In addition to ML modelling, the study emphasizes the emerging role of polymer-based biosensors, microfluidic polymer chips, polymer nanomaterials, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 631–643 Read article
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Green Pastures, Healthy Herd: The Intricate Interplay of Nutrition, Milk Yield, Reproduction, and Welfare in Dairy Cows
Abstract: The study explores the intricate interplay between green pastures, nutrition, milk yield, reproduction, and welfare in dairy cows, emphasizing the multifaceted benefits of pasture-based systems. Green grass serves as a natural, nutrient-rich feed source that supports optimal dairy cow performance by providing essential nutrients such as energy, proteins, vitamins, and minerals, which are crucial for high milk production. The natural grazing behavior associated with green pastures enhances rumen function, facilitating …
Published in Research & Reviews : Journal of Botany · Vol. 14, Issue 2, 2025 · pp. 51–66 Read article
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Analysis of an Extradosed Bridge with Single Plane Cable System
Abstract: The extradosed bridge is a bridge that combines elements of a cable-stayed bridge and a prestressed concrete box-girder bridge. This innovative design offers several advantages, including improved aesthetics, reduced construction costs, and enhanced durability. The extradosed cable system provides additional support to the bridge deck while maintaining a lower overall height compared to traditional cable-stayed bridges. This feature makes extradosed bridges particularly suitable for environments where height restrictions are a …
Published in Trends in Transport Engineering and Applications · Vol. 11, Issue 2, 2024 · pp. 25–31 Read article
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Harnessing Honeybee Venom For Cancer Treatment: A Natural Remedy In Oncology
Abstract: Honeybee venom (HBV) has harvested significant attention as a promising natural compound with therapeutic potential in cancer treatment. This review investigates deeply into the current scientific understanding of honeybee venom, focusing on its anticancer mechanisms, molecular interactions, and potential clinical applications. Honeybee venom comprises various bioactive components, including melittin, apamin, phospholipase A2, and other peptides, which exhibit a wide range of biological activities. Recent research has demonstrated its ability to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 10–14 Read article
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Advances in Polymer Chemistry: The Role of Polymer Composites in Modern Applications
Abstract: Polymer composites have gained immense significance in various industries due to their superior mechanical, thermal, and chemical properties, making them highly versatile materials. These composites are formed by combining polymer matrices with reinforcing agents such as fibers, nanoparticles, or other fillers to enhance specific properties. The field of polymer chemistry plays a crucial role in the development and optimization of these materials, ensuring their suitability for diverse applications. This paper …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 51–56 Read article
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Formulation and Evaluation of a Polyherbal Lip Scrub Containing Beetroot, Licorice, and Aloe Vera
Abstract: The current research is aimed at developing and assessing a polyherbal lip scrub which contains beetroot extract, licorice extract and aloe vera gel to enhance better exfoliation, nutritional and depigmentation. The fusion method was applied to the herbal extract formulations by varying systematically the concentration of the herbal extracts to develop the 4 formulations (F1-F4) each of 15 g. These prepared formulations were tested on their important physicochemical and functional …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 Read article
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Role of Functional Programming Languages in Blockchain Applications
Abstract: Functional programming (FP) languages play an increasingly influential role in blockchain applications, offering features that address critical challenges such as security, scalability, and reliability. The inherent characteristics of FP—immutability, pure functions, statelessness, and concurrency support—align well with blockchain’s decentralized and deterministic structure, making FP languages a natural fit for developing secure and verifiable smart contracts. Languages like Haskell, OCaml, and Erlang have proven effective in minimizing code errors, enabling formal …
Published in Recent Trends in Programming languages · Vol. 11, Issue 3, 2024 · pp. 21–27 Read article
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Perturb and Observe Maximum Power Point Tracking Technique with PID Controller for a Wind Power System
Abstract: The wind power generation system has a significant growth worldwide over the past four decades. The wind power generation system has strong coupling and linear characteristics which makes it a complicated electromechanical system. The power control strategy has a higher impact on the overall performance as the wind power generation is operated at variable and random wind speed conditions. PID control is the most used control algorithm in industrial applications. …
Published in International Journal of Advanced Control and System Engineering · Vol. 1, Issue 1, 2023 · pp. 15–25 Read article
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Gold Nanoparticle Size, Biodistribution, and Toxicity: Insights from DualEnergy CT
Abstract: Dual-energy and spectral computed tomography (CT) have emerged as powerful platforms for noninvasive, quantitative mapping of nanoparticle biodistribution in vivo. By exploiting the energy-dependent attenuation profiles of high-atomic-number (high-Z) materials, these systems enable material decomposition and element-specific imaging, thereby distinguishing nanoparticle signals from those of soft tissues and conventional iodinated contrast agents. Photon-counting spectral CT further enhances this capability by binning individual photons into multiple energy channels, improving spatial resolution, …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 2, 2025 Read article
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Design and Implementation of Low Latency 16-bit Full Adder
Abstract: In the new age world, modern technology has vast applications in various fields of engineering, medicine, and others. Digital electronics processing and systems play a vital role in the analysis and computation of data representation. Electronic systems have gradually become faster and smaller scale. The primary structural element of any modern ALU-based processor is an adder. Addition is a well-known extremely basic function that is employed in nearly all computing …
Published in Journal of VLSI Design Tools and Technology · Vol. 14, Issue 3, 2024 · pp. 21–31 Read article
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Design and Development of Pedalled Powered Electricity Generation
Abstract: Pedal power energy harvesting transforms the mechanical energy produced by pedalling into electrical energy, which can be used to operate devices or saved for future use. The strategy utilizes the physical exertion of pedalling to generate a reliable and eco-friendly energy source. This project aims to develop, construct, and demonstrate a functional mechanism. The generator utilizes the motion of pedalling a regular bicycle to generate electricity. The main goal of …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 16, Issue 1, 2025 · pp. 30–36 Read article
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Reinforcement Learning for Adaptive Sensing with Shape Memory Polymer-Based IoT Nodes
Abstract: The rapid expansion of intelligent sensing in the Internet of Things (IoT) has revealed the pressing need for materials and algorithms capable of self-adaptation in volatile environments. Conventional polymer-based sensors and static control strategies often fail to capture nonlinear thermo-mechanical dynamics, leaving them unsuitable for unpredictable operating conditions. Although prior studies have improved polymer composites or introduced algorithmic optimization independently, few attempts have coupled the adaptability of smart materials with …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 370–391 Read article
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Cancer Chemotherapy-Induced Cachexia: Bridging Mechanisms, Management, and Future Therapies
Abstract: Involuntary weight loss, skeletal muscle atrophy, adipose tissue depletion, anorexia, and systemic inflammation are all symptoms of chemotherapy-induced cachexia, a complex illness. Although it is common, it remains poorly understood and is often referred to as an "orphan disease." This study covers the epidemiology, pathophysiology, clinical symptoms, diagnosis, treatment, and emerging treatment options for chemotherapy-induced cachexia. To comprehend the causes, clinical results, and therapeutic approaches, a literature-based synthesis of recent …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 17–26 Read article
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Role of Pharmaceutical Software in Vaccine Development and Manufacturing Process Optimization
Abstract: Vaccine development and manufacturing have become increasingly complex due to the emergence of diverse vaccine platforms, stringent regulatory expectations, and global demand for safe and effective immunization. Across the vaccine lifecycle – from antigen design and preclinical evaluation to large‑scale manufacturing and post‑marketing surveillance – pharmaceutical software now plays a central role in handling data, optimizing processes, and ensuring regulatory compliance. Software tools support in silico antigen and epitope design, …
Published in International Journal of Vaccines · Vol. 3, Issue 1, 2026 · pp. 1–8 Read article
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Smart Drive Assist Systems for Modern Vehicles: A Review of Current Advances and Future Directions
Abstract: Smart drive assist systems serve as advanced automotive companions, boasting three pivotal capabilities: blind spot monitoring, collision prevention, and adaptive lighting. Blind spot monitoring acts as a vigilant sentinel, overseeing areas beyond the driver's direct view and issuing alerts for potential blind spot intrusions during lane changes. Collision prevention acts as a protective shield, scanning the road ahead to notify the driver of impending collisions, affording crucial reaction time to …
Published in International Journal of Advanced Control and System Engineering · Vol. 2, Issue 2, 2024 · pp. 19–27 Read article
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Computational Modeling of Polymer Semiconductors for Electronic Applications
Abstract: Polymer semiconductors have become important materials in modern electronic applications because they combine semiconducting behavior with mechanical flexibility, low-cost processing, and tunable molecular structure. Their growing use in organic field-effect transistors, organic photovoltaics, organic light-emitting diodes, and flexible sensing devices has increased the need for accurate computational approaches that can predict material properties and device performance before experimental fabrication. This paper reviews the major computational modeling techniques used for polymer …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 132–146 Read article