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308 articles for “Method validation”
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Estimation of Alogliptin and Dapagliflozin in Synthetic Mixture by RP-HPLC Method
Abstract: The primary objective of the proposed research was to develop and validate analytical methods for the simultaneous quantification of Alogliptin and Dapagliflozin in a synthetic mixture. Alogliptin and Dapagliflozin are medications used for managing diabetes, with Alogliptin inhibiting the enzyme Dipeptidyl peptidase-4 and Dapagliflozin belonging to the class of sodium-glucose cotransporter 2 inhibitors. High-performance liquid chromatography method development was conducted using a C18 column (250 mmX4.6 mm, 5 μm particle …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 37–46 Read article
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Exploring Antimalarial Activity of Chalcone Derivatives through QSAR
Abstract: Background: The core structure of chalcones contains a reactive α,β-unsaturated system within the aromatic rings, which plays a key role in mediating various biological effects. These effects include enzyme inhibition, anticancer activity, anti-inflammatory properties, as well as antibacterial, antifungal, antimalarial, antiprotozoal, and anti-filarial actions.Modifying the structure by introducing substituent groups to the aromatic ring can enhance potency, reduce toxicity, and expand their range of pharmacological actions. Methods: A total of …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 1–6 Read article
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Optimizing Antibiotic Analysis: A Comprehensive Guide to HPLC Process of Assessment and Quantification
Abstract: The history and uses of chromatography are thoroughly covered in this work, with an emphasis on the use of High-Pressure Liquid Chromatography (HPLC) in pharmaceutical analysis. Since its discovery by Russian botanist Mikhail Tswett in the 19th century, chromatography has undergone tremendous developments that have given rise to a variety of chromatography types and applications. The story follows the evolution historically, emphasizing Tswett's groundbreaking breakthrough in plant color classification and …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 27–44 Read article
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Multi-phase Flow Simulation Using Computational Fluid Dynamics
Abstract: Computational fluid dynamics (CFD)-based multi-phase flow simulation is a fast developing topic with broad applications in many scientific fields and industry. An extensive account of current developments, difficulties, and uses in multi-phase flow simulations is given in this review paper. Important modeling strategies, numerical methods, validation procedures, and new developments in CFD-based multi-phase flow analysis are covered. This paper is to contribute to the ongoing development and use of CFD …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 1, Issue 2, 2023 · pp. 28–34 Read article
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FEA Simulation for Optimization of Laminated Composite Plate with Cutout in Free Vibrations
Abstract: Laminated composites have a large application in engineering. The work done in this study is to see the free vibration response of graphite epoxy composite square plate subjected to different boundary conditions. Finite element analysis has been done on the software ANSYS. The results obtained by the simulation have been compared with those obtained from a published data obtained by semianalytical solution. It is observed that the solutions through ANSYS …
Published in Journal of Experimental & Applied Mechanics Read article
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Environmental Impact of Chlorantraniliprole in Bell Peppers: Residue Dynamics and Sustainable Practices
Abstract: Bell peppers (Capsicum annuum) are integral to global agriculture and nutrition due to their rich nutrient profile and culinary uses. To protect these crops from pest infestations, Chlorantraniliprole, a widely employed insecticide, has gained prominence. This research investigates the environmental fate of Chlorantraniliprole in bell pepper ecosystems, emphasizing its effects on soil, water quality, and overall ecological health. The study employs a multifaceted approach, conducting field experiments in the Sangli …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 14, Issue 3, 2024 · pp. 1–7 Read article
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A Systematic Review of Advanced Composite Materials for High-Performance Spur Gear Applications
Abstract: This is a review which provides specific and detailed information regarding the fiber-reinforced polymer (FRP) composite to replace traditional steel in high-performance spur gears with emphasis on mechanical performance, computational modeling, and experimental validation. Methods: The current literature was thoroughly investigated that includes material properties, material simulation (e.g., finite element analysis, FEA), and experimental gear testing procedures (e.g., DIN 51354, ASTM G99). Certain case studies in the aerospace and automotive …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 209–220 Read article
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Metagenome-Informed Engineering of Monoclonal Antibodies: Mining Microbial Immunoglobulin-Like Domains for Ultra-Stable Therapeutics
Abstract: Metagenome-informed engineering represents an emerging strategy for improving the stability and functionality of monoclonal antibodies (mAbs) by leveraging the vast diversity of microbial immunoglobulin-like (Ig-like) domains (10,24). These domains, derived from uncultured bacteria and bacteriophages, exhibit exceptional thermostability, protease resistance, and structural resilience due to adaptation to extreme environments (29,30). This review highlights advances in metagenomic mining, structural characterization, and protein engineering that enable the integration of microbial Ig-like scaffolds …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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Analytical Technique Optimization and ICH-Directed Verification of a Reverse Phase HPLC Approach for Quantification of Bupropion Hydrochloride
Abstract: This method was developed for retention time, peak resolution and baseline response using Bupropion Hydrochloride under optimized conditions as validation. The method resulted in two well separated, well defined peaks, a minor peak at 7.5 minutes 12 mV and a main peak at 11.52 minutes 150 mV. At the same time, the baseline has remained stable during the chromatographic run and the fluctuations of noise are very small (0.5 ± …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 47–54 Read article
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Cloud-based Application Development and Optimization
Abstract: As cloud computing powers today’s applications, optimizing cloud-based development is crucial to achieve performance, cost effectiveness, and scalability. This research focuses on enhancing the design, deployment, and maintenance of cloud applications, tackling challenges in resource management, scalability, and resilience. We specifically explore dynamic resource allocation algorithms that use predictive analytics for auto-scaling based on workload variations, aiming to cut costs while preserving high performance. The study also investigates cross-cloud optimization …
Published in Journal of Open Source Developments · Vol. 12, Issue 1, 2025 · pp. 37–42 Read article
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Numerical Simulation of Air Flow Field of A Gas Turbine Engine Air blast Atomizer
Abstract: One of the most crucial process that occurs before the fuel is burned in the combustion chamber is atomization. The performance of a engine will be depend mainly on the fuel mixture. Performance of the engine depends on atomization process because it breaks the bulk fuel into small droplets and injects it into the combustion chamber, in order to make this happen consequently the dimensions of most of the fuel …
Published in Journal of Polymer & Composites · Vol. 11, Issue 13, 2023 · pp. 169–180 Read article
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Toxicology-Focused Development and Validation of an RP-HPLC Technique for Quantifying Bempefoic Acid and Rosuvastatin in a Fixed-Dose Combination
Abstract: A straightforward, precise method was developed to simultaneously assess Bempedoic acid and Rosuvastatin in both bulk and tablet forms. Utilizing a DIKMA Spursil C18 column (4.6 mm x 250 mm, 3.0 μm), chromatography was conducted with a mobile phase comprising 30% phosphate buffer and 70% acetonitrile, flowing at 1 ml/min. Operating at ambient temperature, the optimized wavelength for detection was set at 240 nm, revealing retention times of 4.418 min …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 1–9 Read article
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Experimental Validation and Implementation Framework for Optimized Methane Yield Prediction in Anaerobic Digestion
Abstract: The correct validation and realistic application of optimized anaerobic digestion (AD) models are essential steps in transferring biogas production systems to real-life. This paper outlines an experimental validation and deployment pipeline of an AI-optimized model of the methane yield prediction model based on the application of more advanced machine learning and Bayesian optimization methods. Others The validated surrogate-assisted optimization model was tested with controlled laboratory-scale AD experiments at optimized operating …
Published in International Journal of Environmental Noise and Pollution Control · Vol. 4, Issue 1, 2026 · pp. 25–32 Read article
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Understanding of Research Bias in Herbal Medicine: A Comprehensive Review
Abstract: Background: The communication and generation of knowledge are central to research. In herbal medicine, with its deep historical roots, research must be methodologically rigorous and unbiased to validate traditional knowledge in modern contexts. Bias, defined as any tendency preventing objective evaluation of a research question, compromises validity and reliability. Objective: To highlight types of research bias in herbal medicine and discuss strategies for minimization to ensure credible and applicable findings. …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 1, 2026 · pp. 31–35 Read article
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Integrating Advanced Technologies for the Scientific Revalidation of Ayurvedic Principles
Abstract: Background: Ayurveda, a 5,000-year-old holistic healthcare system, emphasizes the dynamic balance of body, mind, and spirit. Recent advancements in science and technology have accelerated its integration into global healthcare systems. Objective: This paper explores the contribution of modern tools and methodologies to the scientific validation and enhancement of Ayurvedic principles across education, clinical practice, and research. Methods: A comprehensive literature review was conducted using databases like PubMed, Google Scholar, and …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 1–6 Read article
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Literature Review and Research Gaps in Power Quality Enhancement: From Conventional Methods to Intelligent Solutions
Abstract: Power quality (PQ) has become a critical concern in modern electrical power systems due to the rapid integration of renewable energy sources, proliferation of power electronic devices, and increasing sensitivity of loads. This paper presents a comprehensive literature review and research gap analysis of power quality enhancement techniques, ranging from conventional approaches to emerging intelligent solutions. Traditional methods, including passive filters, capacitor banks, and synchronous condensers, have been widely employed …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 4, Issue 1, 2026 · pp. 38–80 Read article
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Establishment of A Set of Similarity Prerequisite Conditions for Low-Cost Similitude Design of Structural System
Abstract: Similitude theory and method is a branch of engineering to establish necessary and sufficient conditions for similarity among complex phenomena. It is of great significance to develop the theory and application method in a more comprehensive way so that the similitude theory can be widely applied to low-cost designs of modern complex structural systems When designing a similitude structural system with various loads and boundary conditions, including rotating machines, it …
Published in Journal of Production Research & Management · Vol. 15, Issue 3, 2025 · pp. 1–15 Read article
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High-Definition Electroencephalography: A New Horizon in Neurological Pathology Research
Abstract: The advent of high-density electroencephalography (HD-EEG) has catalyzed a paradigm shift in the exploration of neurological pathologies. This editorial underscore its transformative potential in elucidating brain dynamics and refining diagnostic approaches for a spectrum of conditions, spanning from epilepsy and dementia to cognitive impairments in preterm infants. Our objective is to optimize the utility of HD-EEG by emphasizing the imperative for methodological homogenization and fostering collaborative endeavors. The remarkable spatial …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 2, 2024 · pp. 15–21 Read article
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Innovative Approaches to Reactive Power Management and Optimization in Modern Power systems
Abstract: Reactive power management and optimization are necessary for the effective, stable, and reliable working of modern power systems. Without proper management, reactive power is responsible for additional losses in transmission, reduced capability of power transfer, and poor voltage stability conditions, thus forming a basis for developing advanced techniques of optimization. This paper discusses the innovative methods in Reactive Power Optimization (RPO) using met heuristic algorithms, namely the Self-Balanced Differential Evolution …
Published in Journal of Power Electronics and Power Systems · Vol. 15, Issue 3, 2025 · pp. 44–50 Read article
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Framework-Based Optimization of Catalysis Efficiency through Reaction Pathway Engineering
Abstract: The rational design of heterogeneous catalysts through framework-based approaches has emerged as a transformative strategy for controlling reaction pathways and enhancing catalytic efficiency. This paper examines recent advances in the optimization of catalytic performance through engineered frameworks, including metal-organic frameworks (MOFs), zeolites, and related porous materials. By integrating computational methods with experimental validation, researchers have achieved unprecedented control overactive site architecture, reactant confinement, and elementary reaction steps. This work reviews …
Published in Emerging Trends in Chemical Engineering · Vol. 13, Issue 2, 2026 · pp. 88–99 Read article