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105 articles for “Cancerous compounds”
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Marine-Derived Pharmaceuticals: Unlocking the Ocean's Potential for Human Health
Abstract: The ocean, covering 70% of the Earth’s surface, is a rich source of unique bioactive compounds with potential therapeutic applications. This review aims to highlight the significance of marine-derived pharmaceuticals in human health, focusing on clinically approved and commercially available medications. The review covers various marine-derived compounds, their structural features, modes of action, and applications in treating diseases, such as cancer, diabetes, and neurodegenerative disorders. The review identifies several marine-derived …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 1–12 Read article
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Induction of G1 Phase Cell Cycle Arrest and Apoptosis in Breast Cancer MCF-7 Cells by Sulphonamide Derivative CID-6861424
Abstract: Breast cancer is most frequently detected and leading cause of cancer death in women worldwide. 80% of the breast cancer are estrogen receptor positive and the presently available drugs are ineffective either due to intrinsic resistance or due to acquired resistance. Sulfonamide compounds are a class of compounds showing activities like, antibacterial, antiviral including antitumor. In the present study we have investigated the anti-cancerous activity of sulfonamide derivative CID-6861424 on …
Published in Research and Reviews: A Journal of Toxicology · Vol. 9, Issue 2, 2019 · pp. 1–17 Read article
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Pharmacoepigenomics of Replication Timing: How Anti- Cancer Drugs Reshape Chromatin Domains and Mutational Landscapes.
Abstract: DNA replication timing serves as a fundamental epigenetic feature that organizes genome function during the cell cycle (3), while anti-cancer drugs profoundly alter this process to disrupt tumor growth(4). These agents target chromatin architecture, shifting replication domains and reshaping mutational patterns critical for cancer evolution (1,5). DNA replication timing (RT) domains serve as dynamic epigenetic organizers, partitioning the genome into early- and late-replicating regions that correlate with chromatin states, gene …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Phyto-Entrapped Carbon Dots as Emerging Nanomaterials for Anti-Cancer Activity
Abstract: Phytoconstituent-loaded carbon dots (C-dots) represent an innovative approach in targeted cancer therapy, combining the therapeutic power of plant-derived compounds with the advanced capabilities of nanotechnology. These ultra-small, biocompatible nanostructures offer excellent fluorescence, tunable surface chemistry, and low toxicity, making them ideal for drug delivery, bioimaging, and theranostic applications. Traditional phytochemicals often face challenges like poor solubility, low bioavailability, and high first-pass metabolism barriers that C-dots help overcome. C-dots synthesized through …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 51–63 Read article
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Integrating Network Pharmacology and Molecular Docking to Investigate Boerhavia diffusa for Pancreatic Cancer Treatment
Abstract: Objective: In this study, network pharmacology was applied to determine the therapeutic effects of the bioactive compounds of Boerhavia diffusa. Network pharmacology can unearth the underlying mechanisms between drugs and the disease targets and aids in the discovery of novel medications for complex conditions such as cancer. Methods: To predict the molecular mechanisms of action of Boerhavia diffusa in the treatment of was screened using the GeneCards database. The Venn …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 29–49 Read article
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Phyto-bioefficiency of Vijaya Extract for Normal Cell Protection and Its Anticancer Efficiency Against Breast Cancer Xenograft
Abstract: Cannabis is an annual, dioecious, flowering herb. Its leaves are palmately compound by serrate leaflets. Cannabis sativa maximum phytochemicals are soluble in organic solvent. The Cannabis plant has been historically used due to its medicinal properties since thousands of years through several beliefs. In India, the department of narcotics has sanction that Cannabis can be grown in a monitored way with proper approval and license. The present study concludes that …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 3, 2022 · pp. 15–21 Read article
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Survey in Hydrazine and its Preparation, Reactions, and Their Applications
Abstract: This review concerned with hydrazine derivatives; Hydrazine is an important chemical compound used in jet engine and rocket fuel. Therefore, the European Union prohibits its sales to the developing world at 100% concentration and only permits its sales at 20-25% concentration. It is also used in industry to produce chemicals for textiles, agriculture, photographic development materials, and blowing agents used in the manufacture of foam rubber. It is also used …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 27–34 Read article
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Anti-Cancer Drugs-Common Types in Libya Tamoxifen: Structure and Synthesis
Abstract: This research reviews the role of anticancer organic compounds, focusing on Tamoxifen as a Selective Estrogen Receptor Modulator (SERM) and briefly comparing it to Vincristine and Vinblastine (Vinca alkaloids). At first, the review includes: classification of cancer stages, revealing symptoms of each stage. Moreover, the review gives an overview of the general classification of most of the cancer drugs, types of cancer drugs used specially in Libya, their structural differences …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 114–123 Read article
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Role of Food Supplements in Premalignant Lesions: A Literature Review
Abstract: Premalignant lesions of the oral cavity are histopathological alterations in the oral epithelium linked to a higher likelihood of malignant transformation. These lesions frequently present as leukoplakia (white patches), erythroplakia (red patches), oral lichen planus, and oral submucous fibrosis. Oral cancer, categorized among head and neck malignancies, is considered the sixth most common cancer globally. While tobacco and alcohol consumption remain the primary etiological factors, increasing evidence underscores the significant …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 3, 2025 · pp. 17–26 Read article
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Pharmacokinetic and Pharmacodynamic Studies of Black Seed Derived Compound
Abstract: Black seed (Nigella sativa) has been celebrated for centuries for its remarkable therapeutic properties. Among its bioactive compounds, thymoquinone (TQ) has gained significant attention in pharmacological research due to its diverse health benefits. This review delves into the pharmacokinetic (PK) and pharmacodynamic (PD) properties of black seed compounds, with a particular emphasis on TQ, the most extensively studied component. The PK of TQ includes the parameters of absorption, distribution, metabolism, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 1, 2025 · pp. 36–43 Read article
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Thymoquinone Induces Epigenetic Modulation in ROS Dependent Manner
Abstract: Traditional drugs have the ability to treat broad range of diseases by modulating the signaling pathwaysof inflammatory diseases and cancer. Epigenetic modulation is also one of the mechanisms already established as a process of action. Histone deacetylase (HDAC) inhibition leads to changes in gene expression promoting cell death. Thymoquinone (TQ), a bioactive compound from Nigella sativa seeds has shown to have an antineoplastic effect in many cancers. Here we have …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 32–39 Read article
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Computational Software Assisted Multiple Therapeutic Targets Oriented Screening of Some Natural Alkaloid Compounds
Abstract: The current efforts endeavor towards the computational exploration of some interestingpharmacological potentials of some natural alkaloids by using the Schrodinger Maestro 9.1software. The excellence in therapeutics was screened against five most imperative targets:Cyclin-Dependent Kinase-5 (anti-cancer), Cycloxygenase-2 (anti-inflammatory), Proteinkinase C (anti-cancer), Dipeptidyl peptidase (anti-diabetic), and Angiotensin-1-ConvertingEnzyme (anti-hypertensive). The alkaloids which were previously reported to possessantibiotic activities against Bacillus subtilis, Staphylococcus aureus, and Mycobacteriumsmegmatis and anti-photo-oxidative, have now perceived to be multi-dimensional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 5–9 Read article
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Harnessing the Bioactive Potential of Calotropis gigantea and Calotropis procera
Abstract: The medicinal plants of the Apocynaceae family Calotropis gigantea and Calotropis procera have gained more and more interest as source of bioactive molecules for biomedical applications like cancer therapy. They have various pharmacological activities, which are believed to be linked to various phytochemical constituents such as cardenolides, cardiac glycosides, flavonoids, triterpenoids, steroids, phenolic compounds, alkaloids, and proteins in their latex. The recent molecular and cellular studies show that extracts and …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
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Review on the Effects of Chemical Compounds Toxicity on Workers in Chemical Laboratories.
Abstract: Chemical laboratories are considered high-risk work environments due to the wide range of chemicals that workers handle, which may be toxic, corrosive, or flammable. Improper handling of these substances can lead to serious health problems, ranging from mild irritation to death in cases of exposure to chemical compounds such as phenols and amines, which cause various types of lung and laryngeal cancers and respiratory diseases in laboratory workers who are …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 2, 2026 · pp. 17–26 Read article
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Papillary Thyroidcarcinoma in Rats After Administration of Platinum Compounds Daily
Abstract: Papillary thyroid carcinoma (PTC) predominantly grows in a solid growth pattern with papillary projections, composed of oncocytic cells with “Orphan annie eyes” nuclei. Cisplatin or Cis-Diammine dichloroplatinum (ii) (Cl2H6N2Pt); is a divalent, inorganic and water-soluble first successful platinum containing anticancer drug, used to treat various forms of cancers. The Carboplatin (C6H14N2O4Pt) and Oxaliplatin (C8H14N2O4Pt) are the investigational chemotherapy medicines, belonging to platinum analogue interfere as the Cisplatin with the genetic …
Published in Research and Reviews: A Journal of Medicine · Vol. 5, Issue 3, 2015 · pp. 27–31 Read article
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A Structure-based Design Approach to Catharanthus roseus Phytoconstituents as Potential Inhibitors of B-Cell Lymphoma 6 Protein
Abstract: Objectives: Lymphoma is a cancerous disease. It develops into millions of people worldwide. Identify the naturally active compounds from Catharanthus roseus, they have multiple values in the medicinal field of Siddha, and Indian Ayurveda are used as a disease-preventing agent. Drug illness prediction, toxicity prediction, statistical information, molecular docking, as well as absorption, distribution, metabolism, and excretion (ADME) analysis are used to predict the fit ligand as a drug. Methods: …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 14–34 Read article
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Azepines, Chemistry, Synthesis and Reactions
Abstract: Azepines, which consist of a seven-membered cyclic compound featuring six carbon atoms, an additional nitrogen atom, and no double bonds between carbons, form a diverse group within organic chemistry. The fully hydrated form of this compound is called azepam (C6H13N). Compounds and their variants play crucial roles in pharmaceutical research due to their biologic attributes like cancer-fighting, bacteria-killing, fungus-busting, virus-suppressing, and inflammation-reducing capabilities. Various organic molecules found within nature draw …
Published in International Journal of Minerals · Vol. 2, Issue 2, 2025 · pp. 35–45 Read article
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Rotenone Beyond Just An Insecticide: A Review
Abstract: Pesticides have received the most attention due to their global application and widespread implications on human health. In recent years, both epidemiological and toxicological studies have provided evidence that pesticides have the potential to act as toxicants contributing to the development of pathogenesis such as neuronal degenerations as well as may be utilized to induce signalling for reversal, suppress or prevent carcinogenic progression. Rotenone, an isoflavones naturally found in the …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 2, 2014 · pp. 8–13 Read article
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Formation, Characterization and Microscopic Study of Four- and Five-membered Ring
Abstract: Types of organic compounds are famous for many industrial and medical applications, including azo compounds, one of the largest groups involved in the manufacture of various organic compounds. For example, they are considered as initiators of free radicals in the polymerization reactions of alkenes used in the manufacture of plastics. Most of cyclic compounds have nano properties which make this type of compound important in organic field. It is also …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 14, Issue 1, 2024 · pp. 1–15 Read article
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A Comprehensive Review of Nutritional Supplements
Abstract: The role of nutrition and nutraceuticals in human health and disease, covering macronutrients, micronutrients, organic acids, trace and macro minerals, vitamins, and bioactive compounds. It outlines biochemical structures, dietary sources, metabolism, physiological functions, and deficiency states of carbohydrates, proteins and amino acids, and fats. Key organic acids, choline, and taurine are described for their metabolic and digestive roles. The document evaluates dietary supplements, functional foods, nutraceuticals, designer foods, and medicinal …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 40–81 Read article