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62 articles for “Metabolic assessment”
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Personalized Nutrition and Exercise: Pioneering the Path to Precision Medicine
Abstract: Preventive healthcare is about to undergo a major shift thanks to the personalised exercise and nutrition paradigm, which is based on precision medicine concepts. In order to create tailored recommendations for improving health outcomes and preventing chronic diseases, this article explores the integration of genetic profiling, metabolic evaluation, and lifestyle factors. A person's response to food and exercise depends heavily on genetic and metabolic variances, which emphasises the need of …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 2, 2024 · pp. 42–46 Read article
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Cis-9, Trans-11 Conjugated Linoleic Acid in Milk: Natural Sources, Nutritional Advantages, and Potential Health Benefits
Abstract: Cis-9, trans-11 conjugated linoleic acid (CLA) is the most common type of CLA found in milk. It has gained a lot of attention because it may have several health benefits. This bioactive lipid is primarily derived from ruminal biohydrogenation of dietary linoleic acid and endogenous synthesis in the mammary gland via Δ9-desaturase activity. Various dietary and management strategies influence CLA concentrations in milk, including forage composition, lipid supplementation, and grazing …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
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A Study to Assess the Nutritional Status of Kidney Failure Patients Undergoing Maintenance Hemodialysis
Abstract: Malnutrition is a common and serious complication among patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis (MHD) and is strongly associated with increased morbidity and mortality. The present study was conducted to assess the nutritional status of patients on maintenance hemodialysis and to identify factors contributing to protein-energy malnutrition in this population. A cross-sectional and follow-up assessment was carried out among patients receiving regular hemodialysis at a dialysis center. …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 3, 2025 · pp. 82–94 Read article
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Assessment of Decellularization Techniques for Fabrication of Tubular Submucosal Scaffolds from Small Intestine for Application in Oesophageal Tissue Engineering
Abstract: In this ground-breaking study, we sought to create superior tubular scaffolds for tissue engineering by utilizing small intestine submucosa (SIS), a remarkable biomaterial with outstanding therapeutic potential. We investigated two standard detergent-perfusion procedures, peracetic acid under perfusion and classic peracetic acid-agitation, to decellularize tubular SIS, with the goal of generating scaffolds with consistent and reliable properties for oesophageal tissue engineering. To assess biocompatibility, we employed metabolic research, microscopy, mechanical tests, …
Published in Journal of Polymer & Composites · Vol. 11, Issue 3, 2023 · pp. 30–38 Read article
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In Silico Analysis and Docking Study of the Active Phyto Compounds of Ginkgo Biloba Against Alzheimer's Amyloid-Beta Protein
Abstract: Objective: Alzheimer's disease, an age-related progressive neurological condition, arises due to the accumulation of amyloid-beta protein within the brain. In this study, an attempt was made to explore the potential of natural compounds derived from Ginkgo, known for their diverse medicinal properties, in the prevention of the disorder by employing molecular docking techniques, conducting drug-likeness prediction assessments, and performing ADME analysis. Methods: Amyloid beta protein was retrieved from the PDB …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 Read article
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Physiological and Psychological Effects of Ekadashi Upavasa (Fasting Ritual) on Women: A Prospective cohort study on Metabolism, Immunity, and Mental Clarity
Abstract: Background: Ekadashi Upavasa, a traditional bi-monthly fasting ritual, is believed to offer physical, mental, and spiritual benefits. However, its scientific impact on metabolism, immunity, and mental clarity remains underexplored. This prospective cohort study evaluates these effects among women practicing the ritual at Krishna Temple, Amloh, over six months. Methods: A total of 800 women aged 25–50 years were recruited from Krishna Temple, Amloh, for this study, conducted from June 2024 …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 2, 2025 · pp. 67–70 Read article
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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Assessing the impact of lifestyle factors on autoimmune risk and survival outcomes: A Population-based Study
Abstract: This study investigated the interplay between lifestyle factors and genetic regulation in autoimmune diseases, focusing on the role of human T-cell metabolic and proliferative control through C-REL gene transcription. This study combined CRISPR-Cas9 manipulation of C-REL in human T-cells with a longitudinal cohort of 100 adults (autoimmune patients and controls), investigating metabolic and proliferation dynamics via flow cytometry and assays. It assessed lifestyle impacts through surveys and medical records, ensuring …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
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Role of Carboxylesterases in Xenobiotic Metabolism and Detoxification: Insights for Cheminformatics Approaches
Abstract: Xenobiotics, which include a wide range of environmental pollutants, food additives, drugs, and carcinogens, are foreign chemical entities that enter the human body and may accumulate, leading to toxic effects. Phase I and phase II metabolic responses are among the detoxification procedures that are necessary to lessen these negative consequences. This review highlights the pivotal role of carboxylesterases (CES), enzymes involved in the hydrolysis of ester, amide, and thioester bonds …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 9–17 Read article
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GLP-1 Receptor Agonists: A Dual Therapeutic Strategy for the Management of Type 2 Diabetes Mellitus and Obesity
Abstract: For the treatment of obesity and type 2 diabetes mellitus (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a revolutionary class of pharmaceutical drugs. These drugs were first created as glucose-lowering treatments, but they have now shown other advantages, such as notable weight loss, better cardiovascular results, and general metabolic control. The objective of this narrative review is to assess the pharmacological mechanisms, clinical efficacy, safety profile, and therapeutic …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 69–75 Read article
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Impact of Spinal Cord Injury on Body Composition and Weight
Abstract: Weight gain is a common consequence of spinal cord injury (SCI), often resulting from decreased physical activity, metabolic alterations, and changes in body composition. This study aimed to assess post-injury weight changes among individuals with SCI. Data was obtained using a multistage random sampling method, utilizing a patient questionnaire administered to 28 individuals diagnosed with SCI. Participants’ baseline weights were compared with their recorded weights at follow-up. The mean initial …
Published in Research and Reviews : Journal of Surgery · Vol. 15, Issue 1, 2026 · pp. 19–34 Read article
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A Community-Based Study to Assess the Impact of Pharmacist Led Home Medication Review in Patients with Diabetes Mellitus in Dakshina Kannada
Abstract: Diabetes mellitus is a chronic metabolic disorder with the condition where there is an abnormally high blood glucose level. Home medication review (HMR) is a patient-centered process that provides the effective and quality use of medication at the patient’s home. According to a study, nearly 50% of Type II diabetes fail to recite adequate glycemic control due to poor management of anti-diabetic medications. So, a community-based interventional study was conducted …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 29–34 Read article
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A Conceptual Framework for AI-Integrated Metabolomics in Predictive Health Systems for Resource-Constrained Environments
Abstract: The increasing prevalence of non-communicable diseases (NCDs) continues to place a significant strain on healthcare systems, particularly in low- and middle-income regions where access to early diagnostic infrastructure is limited. Conventional healthcare approaches remain largely reactive, often detecting diseases at advanced stages when treatment effectiveness is reduced. This challenge underscores the need for predictive, cost-effective, and data-driven healthcare solutions. This study presents a conceptual framework that integrates metabolomics with artificial …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 2, 2026 Read article
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A Review on The effect of Polycystic Ovary Syndrome on some Hormonal and Metabolic Disturbances in Women
Abstract: Polycystic ovary syndrome (PCOS) is a common hormonal condition that affects women of reproductive age. It usually begins to appear during adolescence. The ovaries produce an abnormal amount of "androgens", which are male sex hormones that are usually found in women in small quantities. Ovarian syndrome causes hormonal imbalances, irregular menstrual cycles, increased cysts in the ovaries, in addition to hair growth all over the body, acne, and pain in …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 21–28 Read article
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Exploring Glucagon-like peptide-1 as a Target Protein for Diabetes Mellitus Treatment: Molecular Docking and Pharmacokinetic Analysis of Phytocompounds from Momordica charantia
Abstract: Objective: This study aimed to use molecular docking techniques to explore the potential of GLP-1 (glucagon-like peptide-1) as a target protein for the treatment of diabetes mellitus, a chronic metabolic disease marked by elevated blood glucose levels. Given its crucial role in maintaining insulin secretion and glucose homeostasis, GLP-1 may serve as a future target for diabetes therapy. Method: The study employed a multi-phase method. Initially, protein extraction was carried …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 8–20 Read article
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Microbes: A General Review
Abstract: The exploration of microbes has been a vibrant field of study for over 250 years. Microbiology, in particular, has made significant strides in recent decades, enabling precise diagnosis and treatment of numerous infectious diseases. Today, infectious diseases continue to pose challenges for human health. To mitigate the risks of various infections, there is a growing emphasis on enhancing the production and utilization of antibiotics, which are synthesized from microbial sources. …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 1, 2024 · pp. 48–54 Read article
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Marine Microbial Ecology: A Comprehensive Review of Interactions, Symbiosis, and Bioprospecting.
Abstract: Marine microorganisms constitute the largest and most dynamic fraction of Earth's biodiversity, governing vital ecosystem functions ranging from global biogeochemical cycling to host-specific symbiotic associations. This review provides a comprehensive synthesis of the complex interaction networks within marine microbial communities. We first explore the theoretical foundations of microbial niche construction and evolutionary dynamics in the ocean. Subsequent sections dissect micro-scale interactions within the phycosphere, where chemical gradients dictate cross-kingdom mutualisms …
Published in International Journal of Marine Life · Vol. 3, Issue 1, 2026 · pp. 6–16 Read article
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Circadian Regulation of Lipid Peroxidation in the Brain: Linking Ferroptosis to Neurodegenerative Vulnerability
Abstract: The human brain operates through highly coordinated physiological and biochemical processes that regulate cognition, behavior, and neural adaptability. Central to these processes are mechanisms governing brain function, neurophysiology, and neuroplasticity, which are increasingly recognized to be influenced by circadian rhythms. Recent advances in cognitive neuroscience, neuroimaging, and behavioral neuroscience have revealed that disruptions in circadian regulation can significantly impact oxidative balance within the brain, particularly through enhanced lipid peroxidation. Lipid …
Published in International Journal of Brain Sciences · Vol. 3, Issue 2, 2026 · pp. 1–14 Read article
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TOXICOLOGY: Present-Day Difficulties for Investigating Safety Science and Target Safety Evaluation of Major Human Hepatocytes
Abstract: Preclinical toxicology has developed into a more thorough understanding of toxicity pathways from its descriptive beginnings. Technological developments have made it possible to forecast safety occurrences, mitigate adverse effects, and create safety biomarkers. Because they are able to self-renew and specialize into different types of human body cells, stem cells are currently being employed for in vitro toxicological applications. However, as compared to primary human hepatocytes, stem cell-derived HLCs perform …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 31–40 Read article
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article