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119 articles for “In-vitro”
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In vitro and In vivo Trypanocidal Activity of Methanolic Extract of Lantana camara leaves on Trypanosoma brucei in Laboratory Mice
Abstract: In this study, the methanol extract of Lantana camara leaves were tested for their trypanocidal activity in vitro in a microtiter plate and in vivo using male laboratory mice. Five different concentrations 10mg/ml, 20 mg/ml, 30 mg/ml, 40mg/ml, and 50mg/ml of the extract were prepared and the time taken to immobilize the parasites were recorded. The in vitro results showed that the leave extract at concentrations of 50 mg/ml had …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 2, 2024 · pp. 32–41 Read article
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Development of Sodium Alginate Beads of Telmisartan Using Emulsion Gelation Method: Formulation and In-Vitro Characterization
Abstract: Introduction: The antihypertensive medication Telmisartan (TEL) is a member of BCS class II, which is distinguished by limited oral rate and extent and water solubility. By localizing the medication release in the stomach, gastro-retentive floating bead devices may be able to address the issues related to partial absorption and the low solubility of TEL. The preparation of TEL floating alginate beads was the aim of this investigation. The current work …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 3, 2024 · pp. 13–21 Read article
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Evaluation of Anti-cataract Potential of Carbocisteine by Using In Vitro Goat Lens Model
Abstract: This study includes Carbocisteine has four Oxygen molecules, one Sulfur molecule, and one Nitrogen molecule. Goat eyeballs were used in the present study. They were obtained from the slaughterhouse. Glucose at a concentration of 55 mM was used to induce cataracts; glucose (5.5 mM) concentration served as a normal control, and Ascorbic Acid served as a standard control. Incubation of lenses with glucose 55 mM showed opacification starting after 8 …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Comparative Assessment of Antibacterial Effectiveness, Bioactivity, Fluoride Release, and Microleakage of Various Bioactive Smart Composites: An In Vitro Investigation.
Abstract: The demand for dental composites with enhanced properties has led to the development of bioactive smart composites aimed at addressing multiple aspects of restorative dentistry. This in vitro investigation aimed to conduct a comparative assessment of the antibacterial effectiveness, bioactivity, fluoride release, and microleakage properties of various bioactive smart composites. Bioactive smart composites are emerging dental materials designed to promote remineralization and inhibit bacterial growth, thereby enhancing the longevity of …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 76–86 Read article
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A Brief Review on Dissolution Simulation Software
Abstract: Pharmaceutical industries frequently use simulation software with real-time responses for a variety of purposes, such as dissolution simulation. In essence, it is a tool that lets the user to simulate an operation and see it happen without actually conducting it. Equipments are frequently designed using simulation software to ensure that the finished output will be as near as to the design specifications as possible without costly process adjustments. Advanced computer …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 1–11 Read article
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Formulation Development and In Vitro Evaluations of Trimetazidine and Clopidogrel Bilayered Tablets
Abstract: The Bilayered tablets consisting of Trimetazidine SR as well as Clopidogrel IR were efficiently prepared by damp granulation technique as well as straight compression approach specifically. The prepared powdered mix (SR) were also preserved the physiochemical residential or commercial properties of tablet computers such as thickness, firmness, weight variant, friability and drug material. The enhanced formula consists of the average thickness of 3.1 ± 0.034, average firmness of 4.2 ± …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 3, 2023 · pp. 29–40 Read article
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Enhancing Abiotic Stress Tolerance in Banana (Musa spp.) Using In Vitro Methods and Conserving Germplasm
Abstract: Both biotic and abiotic stressors are the main factors limiting banana output. Research on biotic stressors in bananas has received enough attention globally, whereas abiotic stressors receive less attention. Water availability, salinity, and a wide variety of temperatures are the main problems that must be resolved to maintain banana farming in the twenty-first century. Samples were introduced with water, salt and heat stresses in invitro condition. Under different stress and …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 14, Issue 1, 2025 · pp. 9–15 Read article
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Excoecaria agallocha Extract from Leaves Encounters Antifungal, Antibacterial, and Cytotoxic Activity – In Vitro Studies
Abstract: Mangroves contain a wide range of bioactive substances, certain of and these have been used as solutions for a variation of conditions for thousands of years. Excoecaria agallocha leaf application components have been extracted in the presence of organic solvents along with water-based with a Soxhlet apparatus and antibacterial research properties employing diffusion agar well assays towards nine different kinds of culture infectious agents, six clinical trials isolated compounds, as …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 2, 2025 · pp. 1–7 Read article
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Comparative Evaluation of Fiber-Reinforced Composite and Elastic Fiber Posts in Reinforcing Peri-Cervical Dentin: an In-Vitro Study
Abstract: This study evaluates the fracture resistance of short-fiber reinforced composite and elastic fiber posts compared to conventional hybrid composites in reinforcing peri-cervical dentin of endodontically treated teeth. Methods: The crowns of thirty single-canal mandibular premolars were resected to achieve a dimension of 4mm from 1mm below the highest point of the proximal cervical line. In Group 1, teeth underwent endodontic treatment with gutta-percha filled up to the cement-enamel junction (CEJ) …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 143–149 Read article
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Design, Synthesis, and in vitro Evaluation of Novel Benz/Imidazole-2-acetonitrile Derivatives as Antibacterial and Antifungal Agents
Abstract: Benzimidazole is a pharmaceutically important compound. In this research, we were able to prepare several heterocyclic derivatives from it by first preparing a new azo derivative ZH through a reaction of 3-aminoacetophenone with benzimidazole-2-acetonitrile. This azo derivative was then introduced via a condensation reaction with aromatic amine derivatives, resulting in the preparation of two Schiff base derivatives Z1 and Z2. From these bases, six and seven membered heterocyclic derivatives were …
Published in Emerging Trends in Chemical Engineering · Vol. 13, Issue 2, 2026 · pp. 53–87 Read article
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Advancements in Solubility Enhancement Through Liquisolid Compact Technology: A Comprehensive Review
Abstract: The study examines Liquisolid Compact Technology as an innovative approach for improving the bioavailability and solubility of drugs that are poorly soluble in water. Liquisolid systems, comprising solid carriers and liquid drugs, offer advantages such as improved drug release and bioavailability, reduced manufacturing costs, and controlled drug delivery. The technique involves dissolving or suspending the drug in non-volatile solvents, adding carrier materials, super disintegrants, and coating materials, and then compressing …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 25–34 Read article
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Harnessing Nature: Formulations for Colon Cancer Prevention and Treatment
Abstract: Colon cancer, a rapidly advancing disease worldwide, involves the carcinogenesis of the distal part of the intestine. This malignancy progresses through various developmental stages necessitating diverse treatment approaches. Traditional treatments include drug therapy and chemotherapy; however, emerging methods, such as the use of phytochemical compounds offer promising mechanisms for combating this disease. Phytochemical compounds derived from natural food sources, including flavonoids, tannins, resveratrol, and epigallocatechin-3-gallate, exhibit potent anti-cancer properties. They …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 3, 2024 · pp. 11–23 Read article
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Evaluation of Polysaccharide-Based Membranes for Transdermal Drug Delivery in Chronic Pain Management
Abstract: In order to improve treatment effectiveness and patient compliance, chronic pain management is still a major challenge in modern healthcare, requiring creative medication delivery methods. The potential of polysaccharide-based membranes for transdermal drug delivery is assessed in this work, with particular attention to chitosan, alginate, and hydroxypropyl methylcellulose (HPMC). Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were two characterization techniques used to assess the membranes' physical and chemical …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 28–38 Read article
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Formulation and Evaluation of Betel Leaf and Clove Based Herbal Gel
Abstract: This study developed and assessed a herbal gel comprising extracts of betel leaf (Piper betle) and clove (Syzygium aromaticum) for topical use. Herbal extracts were prepared by Soxhlet extraction and analyzed for yield, phytochemical profile and total phenolic content (TPC). The phytochemicals present were alkaloids, flavonoids, tannins and phenols, and glycosides, with a greater phenolic content for clove extract. Herbal gels were prepared using Carbopol 934 and assessed for properties, …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 2, 2026 Read article
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Fabrication and Comparative Study of Synthetic and Eggshell Waste Derived Hydroxyapatite-Based Composites for Biomedical Applications
Abstract: Hydroxyapatite is widely used as a bioceramic material in orthopedic and dental field because of its exceptional biocompatibility and bioactivity. Hydroxyapatite (HAp) doped with several mineral ions has been frequently reported to further enhance its bioactive nature. Several studies indicate that biological waste materials can serve as calcium sources for hydroxyapatite synthesis, with eggshells being one such promising source. In the present work, two types of hydroxyapatite were synthesized: pure …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 33–46 Read article
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Design and Development of Novel Floating Drug Delivery Systems
Abstract: Recent advances in science and technology have greatly aided in the creation of novel drug delivery methods, especially in addressing physiological issues including irregular stomach emptying times and brief stomach residence periods. Long-term stomach absorption is the goal of gastro-retentive dosage forms (GRDF). Floating drug delivery systems, expanding or swelling systems, polymer-based bioadhesive systems, high-density systems, and other ways that postpone stomach emptying are just a few of the techniques …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 1–22 Read article
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Development and Assessment of Levetiracetam Microspheres Utilizing Synthetic and Natural Polymers: A Biomedical Engineering Perspective
Abstract: In the present study, comparative study of Levetiracetam loaded microspheres using Ethyl cellulose as synthetic and Sodium alginate as natural polymers was done. Solvent evaporation and ionic gelation technique has been successfully employed to produce Levetiracetam loaded ethyl cellulose and sodium alginate microspheres with optimal drug encapsulation that sustained the drug release over a period of time. Based on the pre-formulation studies E1 to E4 and S1 to S4 batches …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 1–18 Read article
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Exploring Biomedical Innovations in the Formulation and Assessment of Medicated Hard Candy Lozenges Containing Metoclopramide Hydrochloride
Abstract: The objective of this study was to formulate and evaluate metoclopramide hydrochloride medicated lozenges for antiemetic action through buccal absorption by incorporating a polymer. All formulations were developed and assessed for in-vitro drug release, physical appearance, weight variation, thickness, hardness, moisture content, mouth-dissolving time, and drug content. The prepared lozenges exhibited uniformity in weight and thickness. The hardness of all formulations ranged between 7.3–15.50 kg/cm², falling within standard limits. The …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 2, 2024 · pp. 50–62 Read article
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Formulation and development of Lamivudine Nanoemulsion by using Emulsifying Polymers and It’s Evaluation
Abstract: Nanoemulsion is a novel approach to medicine delivery that helps to increase the bioavailability of drugs that aren’t particularly soluble in water. In this research work, nanoemulsion of Lamivudine was formulated by using polymers such as SPAN 80, TWEEN 80 and Whey protein concentrate with the help of Ultrasonication technology. The formulation was optimized. It was evaluated by assessing pH, viscosity, turbidity, in vitro franz diffusion study, particle size distribution, …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 22–35 Read article
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Development and Characterization of a Solid Dispersion of an Anti-Diabetic Drug Using Pectin as a Natural Polymer
Abstract: Aim: The current study sought to improve the solubility and oral bioavailability of gliclazide by creating solid dispersions and oral dispersible tablets (ODTs) with enhanced physicochemical characteristics and maintained antidiabetic action. Methods: Preformulation studies were conducted to evaluate the physicochemical properties of gliclazide, including physical appearance, melting point, solubility, and partition coefficient. Solid dispersions were prepared using hydrophilic carriers-pectin and PVP K30, and subsequently characterized by Fourier Transform Infrared Spectroscopy …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article