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Research & Reviews: A Journal of Pharmacognosy Original Research

Formulation and Evaluation of Betel Leaf and Clove Based Herbal Gel

  1. Parmar Harshul Department of School of Pharmacy, Rai University, Ahmedabad
  2. Varma Vishnu Department of School of Pharmacy, Rai University, Ahmedabad
  3. Yadav Laxmi Department of School of Pharmacy, Rai University, Ahmedabad
  4. Shubham Singh Department of Pharmaceutics, School of Pharmacy, Rai University, Ahmedabad
  5. Sanjesh Rathi Department of Pharmaceutics, School of Pharmacy, Rai University, Ahmedabad

Abstract

This study developed and assessed a herbal gel comprising extracts of betel leaf (Piper betle) and clove (Syzygium aromaticum) for topical use. Herbal extracts were prepared by Soxhlet extraction and analyzed for yield, phytochemical profile and total phenolic content (TPC). The phytochemicals present were alkaloids, flavonoids, tannins and phenols, and glycosides, with a greater phenolic content for clove extract. Herbal gels were prepared using Carbopol 934 and assessed for properties, drug content, drug release, and biological activity. The formulations had an acceptable range of pH (6.2-6.7), uniformity, and satisfactory values of viscosity and spreadability. The drug content uniformity was between 96.2% to 98.3%, and showed the homogeneity of active constituents. The in vitro release of the drug from the formulations was found to be 81.6% (F3) after 6 hours. The antimicrobial test results showed a dose-dependent increase. Formulation F3 performed best with regard to drug release and physicochemical characteristics. The research suggests the formulated betel leaf and clove herbal gel is an effective, cost-effective and stable natural product for topical use.

Keywords

References (16)

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