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1972 articles for “mechanisms” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Engineering Anti-Tau Monoclonal Antibodies for Alzheimer’s Disease and Parkinsonian Tauopathies: A Biotechnological Perspective
Abstract: Neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease are characterized by progressive neuronal loss associated with abnormal protein aggregation. Among these, tauopathies are defined by the accumulation of hyperphosphorylated tau protein, which plays a central role in disease progression. Advances in biotechnology have enabled the development of anti-tau monoclonal antibodies (mAbs) as promising therapeutic agents aimed at neutralizing pathological tau species and inhibiting their propagation. This review provides a …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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Marine Fungi – An Expandable Source for Production of Novel Bioactive Metabolites: A Comprehensive Review
Abstract: The marine environment, representing the largest and most extreme biome on Earth, serves as an unparalleled reservoir of biodiversity. Within this vast ecosystem, marine fungi have emerged as a prolific source of structurally diverse and pharmacologically active secondary metabolites. Dwelling in habitats characterized by extreme high salinity, high hydrostatic pressure, and low temperatures, these microorganisms have evolved unique biochemical and metabolic pathways to synthesize novel compounds, including pyrrole-imidazole alkaloids, cyclic …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 30–37 Read article
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GLP-1 Receptor Agonists: A Dual Therapeutic Strategy for the Management of Type 2 Diabetes Mellitus and Obesity
Abstract: For the treatment of obesity and type 2 diabetes mellitus (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a revolutionary class of pharmaceutical drugs. These drugs were first created as glucose-lowering treatments, but they have now shown other advantages, such as notable weight loss, better cardiovascular results, and general metabolic control. The objective of this narrative review is to assess the pharmacological mechanisms, clinical efficacy, safety profile, and therapeutic …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 69–75 Read article
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Bridging the Gap Between Product Development and Entrepreneurship in Engineering Curriculum: A Framework-Based Approach Aligned with NEP 2020
Abstract: Despite advancements in technical education, Indian engineering graduates frequently enter the workforce lacking critical competencies in product development (PD) and entrepreneurship. This imbalance has drawn scrutiny from industry and policymakers alike, with national directives such as the National Education Policy (NEP 2020) emphasizing a shift toward “experiential, holistic, integrated and inquiry-driven” learning models. Similarly, the All-India Council for Technical Education (AICTE) has embedded innovation labs, internship mandates and entrepreneurship courses …
Published in International Journal of Education Sciences · Vol. 3, Issue 1, 2026 · pp. 87–100 Read article
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Wireless Charging Station for Electric Vehicle
Abstract: In order to simplify the charging process, lessen reliance on physical connectors, and improve overall user convenience, this article describes the design and execution of an efficient wireless charging station for electric cars (EVs), the system use the microcontroller to control all the parts which is added in the project such as lcd, uno , etc. Safety is a key designs, it integrated thermal management and fault detection mechanisms to …
Published in International Journal of Electrical and Communication Engineering Technology · Vol. 4, Issue 1, 2026 · pp. 41–47 Read article
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LQR-Based Optimal Control of Inverted Pendulum System with State Estimation and Stability Analysis
Abstract: The inverted pendulum on a cart is a canonical benchmark problem in control systems engineering, capturing the essential challenges of stabilizing an inherently unstable, underactuated, and nonlinear plant. Classical Proportional-Integral-Derivative (PID) controllers, while widely employed in industrial practice, exhibit fundamental performance limitations when applied to such systems, primarily due to their inability to account for multivariable coupling, process noise, and the absence of a systematic optimization framework. This paper presents …
Published in International Journal of Advanced Control and System Engineering · Vol. 4, Issue 1, 2026 · pp. 31–43 Read article
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3D Printing of Polymer-Based Functionally Graded Materials: Recent Developments and Challenges
Abstract: Additive manufacturing (AM), specifically 3D printing, has become a useful technique for fabricating functionally graded materials (FGMs) because it can facilitate the spatial distribution of materials. Polymer FGMs (P-FGMs) have gained a great deal of interest due to their lightweight, customizable, multifunctional properties. In comparison to conventional fabrication, 3D printing allows better control of composition and microstructure, which results in materials with controlled mechanical, thermal, and biological properties. This review …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 338–347 Read article
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AI-Accelerated Development of Gradient Polymer Nanocomposite Thin Films
Abstract: Gradient polymer nanocomposite thin films are an active field of materials research due to the fact that it enables scientists to de-facto regulate the optical, electrical, and mechanical properties of a film by merely altering its composition on a layer-by-layer basis. This type of control opens the gate to the improved flexible electronics, long lasting protective coats, and the new smart gadgets. The problem is, though, that it is a …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 456–469 Read article
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How do Polymer-derived Implants Influence Patient-Reported Outcomes (PRO) in Cardiovascular and Orthopaedic Procedures
Abstract: Implants derived from polymers have surfaced as adaptable substitutes for conventional metallic devices in cardiovascular and orthopedic treatments because of their adjustable mechanical characteristics, biocompatibility, radiolucency, and ability for surface alteration. This systematic review assesses the impact of polymer-based implants such as PEEK, UHMWPE, bioresorbable polymer scaffolds, and drug-eluting systems on outcomes reported by patients (PROs). Findings from 42 qualifying studies show overall positive impacts on pain alleviation, functional recovery, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1821–1834 Read article
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An Integrated Simulation Framework for Predicting Dielectric Breakdown and Electrical Aging in Epoxy-Silica Composite Insulation Systems
Abstract: This paper provides a combined computation approach in forecasting the dielectric breakdown and electrical aging within epoxy-silica composite of insulation system. The approach will consist of a three-complementary methodology (a combination of computing electric field using the finite element analysis, estimation of the probability of failures or breakdowns using Weibull statistics, and prediction of degradation tendencies using artificial neural networks). The epoxy-silica composites are of 10-40 volumes fillers. The simulations …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 339–376 Read article
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Optimization of Pesticide Requirement Calculations for IoT-Operated Hexacopter Delivery Systems
Abstract: The integration of Internet of Things (IoT) technology into precision agriculture has transformed pesticide application strategies, enabling resource-efficient and environmentally sustainable practices. This study presents a computational methodology for optimizing pesticide requirements in an IoT-operated hexacopter system, designed for dynamic, data-driven pesticide delivery. Leveraging a fusion of real-time telemetric data from onboard LiDAR, multispectral imaging sensors, and environmental monitoring modules, the system employs predictive analytics and edge computing to calculate …
Published in International Journal on Drones · Vol. 2, Issue 1, 2026 · pp. 08–14 Read article
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Effect of Aging on the Performance of Polymer Composite: A Review
Abstract: The exceptional robustness, corrosion resistance, and lightweight design, polymer composites (PCs) are crucial to modern engineering escalating the utilization of polymer composite in structural applications including aerospace engineering, automobile engineering, etc. With a greater number of positive aspects, the polymer composite also deteriorate by different environment conditions with their exposing duration considered as aging of polymer composites. However, a variety of elements influencing the ageing process determine their long-term performance. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 752–768 Read article
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Modulating Immune System of Mosquitoes with A Novel Salicylate Derivative: A Bioinformatics-Based Study
Abstract: The present study aims to compare the interactions of a novel derivative of salicylic acid, 5-(2-nitroethynl) salicylic acid (5-SANA, salicylic acid nitroalkene), and salicylic acid with the critical residues of mosquito’s juvenile hormone binding protein (mJHBP). Given the better water solubility of 5-SANA and salicylic acid, it is believed that they can interact quicker than the natural substrate, juvenile hormone (JH), with the cavity of mJHBP, a circulating protein in …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 · pp. 1–5 Read article
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Sustainable Architecture for Rural Communities: The Tanzanian Family House Model
Abstract: Sustainable rural housing in East Africa must respond simultaneously to climatic stress, water scarcity, sanitation challenges, and socio-cultural practices. This article presents the Tanzanian Family House as a climate-responsive and resource-efficient housing model developed specifically for rural Tanzanian communities. The project integrates low embodied energy materials, passive environmental strategies, and decentralized infrastructure systems to create a durable and culturally grounded dwelling that can be constructed using local skills and materials. …
Published in International Journal of Rural and Regional Development · Vol. 4, Issue 1, 2026 · pp. 1–12 Read article
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Enhancing Rhizoremediation of Petroleum Hydrocarbon-Contaminated Soil Using Brachiaria ramosa: A Review of Plant Growth Promotion and Degradation Potential
Abstract: This paper examines rhizoremediation as a sustainable and environmentally acceptable remediation technique in response to the growing problem of petroleum hydrocarbon pollution in soils. Brachiaria ramosa, a tropical grass species that may be useful in contaminated settings, is the main emphasis. A critical analysis of the literature on plant growth-promoting rhizobacteria (PGPR), microbial consortia involved in hydrocarbon breakdown, and rhizosphere-mediated degradation is conducted. There is a thorough discussion of important …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 · pp. 24–41 Read article
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AI-Designed Functionally Graded Polymer Composites for Multifunctional Thin Films
Abstract: The design of multifunctional polymer composite thin films requires simultaneous optimization of mechanical, optical, barrier, and thermal properties—objectives often in conflict when using conventional homogeneous materials. This study presents an artificial intelligence-driven framework for designing functionally graded material (FGM) architectures in polymer nanocomposite thin films. We integrated machine learning with physics-based modeling to optimize compositional gradients across film thickness, achieving superior performance compared to homogeneous and discrete multilayer alternatives. A …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1026–1041 Read article
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Nano-Chemical Revolution in Vaccinology: A Study
Abstract: The development of traditional vaccines, reliant on attenuated pathogens or purified proteins, has historically been limited by slow development timelines, poor stability, and low immunogenicity requiring potent, often non-specific, adjuvants. This synthesis argues that the convergence of nano-material science and meticulous chemical engineering represents the next major paradigm shift in preventative medicine. Nano-materials, particularly Lipid Nanoparticles (LNPs) and various polymeric or inorganic scaffolds, have transitioned from theoretical constructs to essential …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 Read article
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Compatative Catalytic Study of Oxidation of Thiourea by Chromium (VI) in Presence of Different Catalysts and Micelles
Abstract: The series of catalysts like acetate, oxalate, EDTA, the varies micelles viz, CTAB, SDS, TRITON X-100 was carried out in the kinetic study of oxidation of Thiourea by Cr(VI) as an oxidant in water medium. The effect of catalytic efficiency has been study for varies catalyst and micelles by volumetric method and UV spectroscopic methods. The product was confirmed by IR studies. UV study reveals shows that higher catalytic efficiency …
Published in International Journal of Advance in Molecular Engineering · Vol. 4, Issue 1, 2026 · pp. 9–21 Read article
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Footstep Power Generation Using Piezoelectric Materials: A Renewable Approach for Smart Infrastructure
Abstract: The rapid depletion of fossil fuels and the increasing global demand for sustainable energy have necessitated the development of decentralized energy harvesting systems. This paper presents a comprehensive study on footstep-based power generation using piezoelectric materials as a viable renewable energy solution for smart infrastructure. The proposed system converts mechanical energy generated from human locomotion into electrical energy using optimized piezoelectric transducer arrays integrated beneath floor tiles. The study covers …
Published in Trends in Electrical Engineering · Vol. 16, Issue 1, 2025 Read article
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A Comprehensive Review of Ethnobotanical Studies on Traditional Indian Herbal Plants for Lung Cancer Management
Abstract: Lung cancer is a leading cause of cancer-related deaths in the world. Current therapies for lung cancer are often limited by many side effects. This review compiles and evaluates ethnobotanical evidence and modern scientific findings of Indian herbal plants traditionally used for respiratory and tumor-related disorders, with a focus on their relevance to lung cancer management. Herbal phytochemicals and how they show their potent activities were also listed in this …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 1, 2026 · pp. 1–7 Read article