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Research & Reviews : Journal of Herbal Science Review Article

A Comprehensive Review of Ethnobotanical Studies on Traditional Indian Herbal Plants for Lung Cancer Management

  1. Sparsh Shah School of Pharmacy, Rai University, Ahmedabad
  2. Jayalekshmi M. Department of Pharmacology, School of Pharmacy, Rai University, Ahmedabad
  3. Mahi Solanki School of Pharmacy, Rai University, Ahmedabad
  4. Makwana Divya School of Pharmacy, Rai University, Ahmedabad
  5. Karan Solanki School of Pharmacy, Rai University, Ahmedabad

Abstract

Lung cancer is a leading cause of cancer-related deaths in the world. Current therapies for lung cancer are often limited by many side effects. This review compiles and evaluates ethnobotanical evidence and modern scientific findings of Indian herbal plants traditionally used for respiratory and tumor-related disorders, with a focus on their relevance to lung cancer management. Herbal phytochemicals and how they show their potent activities were also listed in this study. Traditional Indian plants can manage lung cancer via various mechanisms such as induction of apoptosis, inhibition of PI3K/Akt and STAT3 pathways, suppression of metastasis-related genes, modulation of oxidative stress, and enhancement of host immune responses. Quercetin, kaempferol, apigenin, vincristine, vinblastine, matrine, ursolic acid, betulinic acid, paclitaxel, caffeic acid, etc. are the major phytochemicals which are responsible for the management of lung cancer. Plants, like Curcuma longa, Withania somnifera, Tinospora cordifolia, Ocimum sanctum, Azadirachta indica, Andrographis paniculata, Phyllanthus amarus, Boerhavia diffusa, Glycyrrhiza glabra, & Zingiber officinale, are the few Indian plants has various derivatives of phytochemicals utilize to manage cancers in respiratory system. These plants exhibit anticancer activity in the control of lung cancer via different pathways like apoptosis (programmed cell death), arrest in cell division, angiogenesis inhibition & metastasis, alteration of oxidative stress and disruption of signaling pathways. This review study mainly focusing on various Indian plants utilizing in the management of lung cancer and their diverse pathways to induce the cancer cells. Also included artificial intelligence data in the diagnosis and monitoring. By bridging traditional knowledge and contemporary biomedical research, this review aims to accelerate development of plant-derived interventions that are safe, effective, and culturally appropriate for lung cancer management

Keywords

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