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1953 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Nanoparticle-Based Early Diagnostic Tools for Tuberculosis and Malaria in Rural India
Abstract: Malaria and Tuberculosis continue to be two major public health challenges in rural India. The interplay between an inefficient health care system, late diagnosis, and under-identification of cases contributes to the high morbidity and mortality associated with TB and Malaria. Conventional methods, such as sputum microscopy for TB, microscopy and rapid diagnostic tests (RDTs) for malaria, have a higher benchmark of sensitivity that requires a certain amount of time, skilled …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 45–51 Read article
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Microneedles: An Innovative Drug Delivery System
Abstract: Microneedles represent a groundbreaking innovation in drug delivery systems, offering a transformative alternative to conventional hypodermic needles and transdermal patches. This advanced technology combines the precision and efficacy of needle-based delivery with the convenience and pain-free nature of patches, creating a minimally invasive platform that addresses many limitations of traditional drug administration. Microneedles are designed to penetrate the stratum corneum – the skin’s outermost layer – without reaching pain-sensitive nerves …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 60–67 Read article
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Collaborative Care for Diabetic Retinopathy: Integrating Artificial Intelligence and Clinical Pharmacy Services - A Comprehensive Review
Abstract: Background: Diabetic retinopathy (DR) remains the leading cause of blindness among working-age adults globally, affecting approximately 103 million people worldwide. The integration of artificial intelligence (AI) technologies with clinical pharmacy services presents unprecedented opportunities to enhance screening, diagnosis, and management of DR through collaborative care models. Objective: This comprehensive review examines the current landscape of collaborative care approaches for diabetic retinopathy management, focusing on the integration of AI-powered diagnostic tools …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 118–128 Read article
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Understanding the Cervical Spine Disorder: A Cross-sectional Survey Study
Abstract: Cervical spine disorders encompass a spectrum of conditions including degenerative spondylosis, disc herniation, traumatic injuries, and myelopathy that impair quality of life through chronic pain, neurological deficits, and functional limitations. Globally, neck pain affects over 200 million individuals, with an age-standardized prevalence of 2666 per 100000 population and an incidence of 816 per 100000 person-years, contributing to significant years lived with disability (YLDs). Economic analyses estimate annual direct healthcare costs …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 80–97 Read article
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Seismic Hazard Evaluation through Attenuation Law Derivation and Response Spectrum Design: Bangladesh Case Study
Abstract: Bangladesh, positioned at the confluence of the Indian, Eurasian, and Burma tectonic plates, faces significant seismic hazards due to its complex geological setting. This research focuses on formulating empirical attenuation relationships and Creating a design response spectrum for assessing seismic risks in Bangladesh, using data from ten large earthquakes with magnitudes ranging from 6. 7 to 7. 9. The study creates Ground Motion Prediction Equations (GMPEs) for various structural periods …
Published in Journal of Structural Engineering and Management · Vol. 12, Issue 3, 2025 · pp. 54–63 Read article
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Extended Fixed Point Theorems in Menger PM-Type Spaces: Generalized Auxiliary Functions and Contractivity Conditions
Abstract: Background: Fixed point theory in probabilistic metric spaces, particularly Menger spaces, has been a subject of intensive research due to its applications in nonlinear analysis and mathematical modeling. Traditional approaches often impose restrictive constraints on the defining properties of Menger spaces and limit the class of auxiliary functions in contractivity conditions Methods: We extend recent fixed point theorems in Menger spaces by: (1) introducing the notion of Menger PM-type spaces …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 12, Issue 3, 2025 · pp. 1–6 Read article
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High grade nuclear heat supply from molten salt reactors via pipelines: Parametric studies on heat loss
Abstract: Nuclear power plants based on molten salt technology have the potential to supply low carbon emissions intensity thermal energy and electricity to support industrial decarbonization. The primary coolant of these reactors is a multi-component fluoride salt like FLiNaK and this stream can be partly extracted to serve as industrial heat source with temperatures of about 550-600oC. This study examines the pipeline-based transport of this heat source to a potential point …
Published in Research & Reviews : Journal of Physics · Vol. 14, Issue 3, 2025 · pp. 01–08 Read article
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Integrated Spatial and Statistical Assessment of Groundwater Quality in Rupbas Tehsil of Bharatpur, Rajasthan: A WQI-based Approach
Abstract: This study presents a comprehensive evaluation of groundwater quality in Rupbas Tehsil of Bharatpur District, Rajasthan, through the application of the Water Quality Index (WQI) and hydrogeochemical techniques. A total of 32 groundwater samples, 16 collected during the pre-monsoon and 16 during the post-monsoon seasons, were analyzed for key physicochemical parameters including pH, electrical conductivity (EC), total dissolved solids (TDS), dissolved oxygen (DO), oxidation-reduction potential (ORP), total hardness (TH), total …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 3, 2025 · pp. 84–93 Read article
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Design of Dual Media Water Filter Purifier Using Clay Pot
Abstract: Numerous organisations make low-cost water treatment devices for rural homes, for instance filters, RO and UV-based water purifiers. However, these devices have problems like filter clogging, the need to replace filters frequently water contamination (in the case of RO), and the truth that electricity is not always available in rural areas, which makes them costly to use. Because of this, RO and UV purifiers are too expensive for people who …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 3, 2025 · pp. 94–99 Read article
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Low Velocity Impact Behaviour of Corrugated Foam Sandwich Panel
Abstract: Composite sandwich structures, renowned for their high flexural stiffness and low weight, are widely used across industries such as aerospace, automotive, and marine. However, their durability can be compromised by impact-related damages, which affect both the core and face sheets. This study explores the performance of corrugated sandwich panels compared to conventional designs under low-velocity impacts. Using a drop weight impact testing machine, panels made from polyurethane foam cores and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 79–99 Read article
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Comprehensive Strategies for the Prevention and Management of Genital Thrush in Males and Females: A Public Health Approach in Punjab (September 2024 to February 2025)
Abstract: Background: Genital thrush, a common fungal infection caused mainly by Candida albicans, affected both men and women, leading to itching, discomfort, and recurrent infections. In Punjab, high humidity, poor hygiene awareness, excessive antibiotic use, and limited access to healthcare contributed to its widespread occurrence. Without effective prevention and management strategies, the condition significantly impacted quality of life. Addressing this issue through a public health approach was essential for reducing its …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 3, 2025 Read article
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Integrated Optimization of Solar Photovoltaic Systems Using Taguchi Method and Computational Fluid Dynamics for Enhanced Efficiency
Abstract: The transition to renewable energy demands efficient and reliable photovoltaic (PV) systems to meet rising global energy needs. This study presents an integrated optimization framework combining the Taguchi method and Computational Fluid Dynamics (CFD) to improve the thermal and electrical performance of solar PV systems. A structured experimental design using an L9 orthogonal array evaluates the influence of three key parameters—material type, panel thickness, and cooling mechanism—on system efficiency. Analysis …
Published in Recent Trends in Fluid Mechanics · Vol. 12, Issue 3, 2025 · pp. 10–25 Read article
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Polymer–Gel Composite Phase Change Materials: A Functional Polymer Composite Approach for Solar-Thermal Energy Storage in Building Facades
Abstract: This study investigates polymer–composite phase change materials (PCMs) in the form of polymer–gel hybrids as multifunctional systems for solar–thermal energy storage in building façades. Paraffin- and PEG-based PCMs were embedded into polyurethane and acrylic gel matrices to create shape-stabilized polymer–composites with high PCM loading (70–80 wt%). Differential Scanning Calorimetry (DSC) confirmed distinct melting/freezing transitions at ~56°C (paraffin) and ~42°C (PEG), with enthalpy values of 120–150 J/g, closely matching theoretical predictions, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 36–51 Read article
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Microneedles: A Modern Breakthrough in Drug Delivery Systems
Abstract: Microneedles (MNs) represent a revolutionary and transformative advancement in the realm of transdermal drug delivery systems, which are designed to facilitate the administration of therapeutic agents through the skin. These exceptionally small, micron-scale needles penetrate the stratum corneum, thereby enabling the direct delivery of pharmacological agents into the underlying dermis or the upper epidermis, consequently enhancing bioavailability while simultaneously circumventing the detrimental effects of first-pass metabolism and the degradation that …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 01–07 Read article
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Samelisant, an H3 Receptor Agonist as an Anti-Alzheimer Potential – A Pilot Study on Molecular Docking
Abstract: Neurodegenerative diseases have become more prevalent and about 55 million of the population are affected by dementia globally. One of the most important neurodegenerative diseases is Alzheimer’s disease which is known for its effect on memory and cognitive impairment. Alzheimer’s disease (AD) is an area of intense scientific investigation due to its high prevalence and the lack of a definitive cure. Amyloid precursor protein plays a central role in Alzheimer’s …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 · pp. 15–26 Read article
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Study of Hydrophytes in Lakes of Bhadrawati Region, District-Chandrapur, Maharashtra, India
Abstract: Hydrophytes play a crucial role in aquatic ecosystems as good indicators of water pollution. The present survey was carried out from September 2023 to August 2024. During this study period, a total of 25 macrophytes belonging to 4 free-floating species, 7 free-floating suspended submerged species, 05 rooted floating leaves species, 6 rooted submerged species, and 3 rooted emergent species were observed in six lakes (Dhoodhala lake, Lendara lake, Mashanghat [Malhar] …
Published in Research & Reviews : Journal of Botany · Vol. 14, Issue 3, 2025 · pp. 16–28 Read article
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Integrating Digital Twins, Smart Materials, and Human Machine Collaboration for Sustainable Smart Manufacturing: Smart CNC & Industry 4.0 Applications
Abstract: The rapid evolution of Industry 4.0 and the emerging transition toward Industry 5.0 have been catalyzed by the convergence of intelligent digital technologies such as digital twins, cyber–physical systems (CPS), artificial intelligence (AI), the Internet of Things (IoT), and human-in-the-loop (HITL) frameworks. These technologies have transformed traditional manufacturing into adaptive, data-centric ecosystems capable of real-time optimization and predictive decision-making. In recent years, the fusion of computer numerical control (CNC) machines, …
Published in International Journal of Manufacturing and Production Engineering · Vol. 3, Issue 2, 2025 · pp. 1–8 Read article
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Evaluation of dampness effect on some buildings in Ahmadu Bello University, Zaria, Nigeria
Abstract: Dampness is one of the sources of defect in building. Apart from triggering deterioration of the material and textures, it can also affect in harm to the furnishings and content there by allowing the development of fungi. There are many causes of dampness in building some of which include rain penetration which occurs ingress above the ground at the various points in the external envelope of the construction. i.e through …
Published in Journal of Structural Engineering and Management · Vol. 12, Issue 3, 2025 Read article
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A Literature Survey on Biological Activities of Thiazolidine Derivatives
Abstract: Hetercyclic compounds play a vital role in both chemical and life sciences. Among them ,thiazolidinone represent a significant class, characterized by a five- membered saturated ring containing both sulfur and nitrogen atoms. Structurally, thiazolidinones are derived from thiazole, with sulfur position at the 1-position, nitrogen at the 3-position , and a carbonyl group typically located at the 2-, 4-, or 5- position are possible, though structural and functional diversity is …
Published in International Journal of Cheminformatics · Vol. 3, Issue 2, 2025 · pp. 16–21 Read article
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Fabrication and Assessment of Tribological Performance of Nickel-Graphene-MXene Hybrid Nano-composites
Abstract: As industries such as aerospace, automotive, defence, and electronics demand materials with superior wear resistance, high strength, and thermal stability, traditional metals are reaching their performance limits. Hybrid nanocomposites offer a pathway to meet these stringent requirements. In this study, novel Nickel-Graphene-MXene hybrid nanocomposites were fabricated using a powder metallurgy route, incorporating varying weight percentages (up to 2 wt.%) of MXene and 1 wt.% graphene nanosheets into a nickel matrix …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 780–798 Read article