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Trends in Drug Delivery Review Article

Microneedles: A Modern Breakthrough in Drug Delivery Systems

  1. Ujjawal Tamboli Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh
  2. Pankaj Chasta Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh
  3. Chhaya Deval Malook Pharmaceutical Pvt. Ltd.
  4. Shivam Rongpi Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh
  5. Kamalesh Mistry Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh

Abstract

Microneedles (MNs) represent a revolutionary and transformative advancement in the realm of transdermal drug delivery systems, which are designed to facilitate the administration of therapeutic agents through the skin. These exceptionally small, micron-scale needles penetrate the stratum corneum, thereby enabling the direct delivery of pharmacological agents into the underlying dermis or the upper epidermis, consequently enhancing bioavailability while simultaneously circumventing the detrimental effects of first-pass metabolism and the degradation that often occurs within the digestive system. Fabricated from a variety of materials including, but not limited to, metals, polymers, silicon, and various sugars, microneedles are produced through cutting-edge manufacturing processes such as photolithography, micromolding, and advanced 3D printing techniques, and they can be classified into several categories including solid, coated, dissolving, hollow, and hydrogel-forming. They have exhibited remarkable potential across a wide array of applications, including cosmetic enhancements, diagnostic purposes, oncological treatments, vaccination strategies, and innovative drug delivery systems. Despite the numerous advantages that microneedles offer, such as enhanced patient compliance and the convenience of self-administration, there remain significant challenges that must be addressed, including issues related to mechanical strength, inadequate drug loading capabilities, and various regulatory hurdles that could impede their widespread adoption. The ongoing research focused on the development of intelligent microneedles and personalized therapeutic approaches underscores the pivotal role that microneedles are poised to play as an essential innovation in the future landscape of healthcare solutions.

Keywords

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