7 publications
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Published Subscription Review Article
Plant-Derived Antimicrobials as Next-Generation Solutions to Multidrug ResistanceBy Rohit Kumar, Shraddha Pareek, Tanya Sharma, Kamalesh Mistry
Abstract: The steady rise of multidrug-resistant (MDR) pathogens is reshaping how clinicians, researchers, and policymakers think about infection control. When bacteria acquire the ability to survive exposure to three or more antibiotic classes at once—whether through efflux pumps, enzyme-mediated drug destruction, target modifications, or reduced membrane permeability—treatment options narrow dramatically, hospital stays lengthen, and mortality climbs. Conventional pharmaceutical pipelines have struggled to keep pace with this biological arms race, pushing the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article →
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Published Subscription Review Article
Microneedles: A Modern Breakthrough in Drug Delivery SystemsBy Ujjawal Tamboli, Pankaj Chasta, Chhaya Deval, Shivam Rongpi, Kamalesh Mistry
Abstract: Microneedles (MNs) represent a revolutionary and transformative advancement in the realm of transdermal drug delivery systems, which are designed to facilitate the administration of therapeutic agents through the skin. These exceptionally small, micron-scale needles penetrate the stratum corneum, thereby enabling the direct delivery of pharmacological agents into the underlying dermis or the upper epidermis, consequently enhancing bioavailability while simultaneously circumventing the detrimental effects of first-pass metabolism and the degradation that …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 01–07 Read article →
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Published Subscription Original Research
Development and Optimization of Orally Disintegrating Tablets (ODTs) Containing Standardized Curcumin Extract for Enhanced Bioavailability and Patient ComplianceBy Rupesh Kumar Pandey, Kamalesh Mistry, Dhananjay Mistry, Shivam Rongpi, Pratyush Kumar Brahma, Mitul Bhoi
Abstract: This research centers on creating and perfecting orally disintegrating tablets with standardized curcumin extract to both increase its bioavailability and promote better patient adherence. Although curcumin has numerous therapeutic applications. It remains clinically ineffective due to its poor aqueous solubility and bioavailability constraints. The development of orally disintegrating tablets involved direct compression with various levels of superdisintegrants including sodium starch glycolate and cross povidone to address existing challenges. Research teams …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 1–06 Read article →
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Published Subscription Original Research
Formulation, Evaluation, and Stability Studies of a Topical Clotrimazole and Zinc Oxide Suspension with Enhanced Skin Protective PropertiesBy Ujjawal Tamboli, Pankaj Chasta, Chhaya Deval, Shivam Rongpi, Kamalesh Mistry
Abstract: Background: Clotrimazole is a well-known antifungal agent frequently used in the treatment of various superficial fungal infections, while Zinc Oxide is a widely accepted skin protectant with soothing, astringent, and antimicrobial properties. Combining these agents in a topical suspension offers a dual therapeutic approach, enhancing both antifungal efficacy and skin protection. Objective: The objective of this study was to formulate, evaluate, and conduct stability studies on topical suspensions containing Clotrimazole …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 22–31 Read article →
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Published Subscription Review Article
An Overview of Gene TherapyBy Santosh Kumar Saw, Kamalesh Mistry, Dhananjay Mistry, Md. Aftab Alam
Abstract: Gene therapy is a revolutionary technique in medical science that seeks to cure or stop illnesses by means of introducing, altering, or quieting genes inside a patient's cells. Advancements in molecular biology, genetics, and biotechnology have propelled this field forward markedly changed over the last few decades. The underlying idea of gene therapy is to introduce genetic material into target cells via viral or non-viral vectors to rectify faulty genes, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 89–105 Read article →
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Published Subscription Review Article
Chronic Obstructive Pulmonary Disease (COPD) in Younger Adults: Challenges and Considerations – A ReviewBy Sajad Ali Dar, Kamalesh Mistry, Dhananjay Mistry, Md. Aftab Alam, Komal Maliwal, Neha Nahid
Abstract: Chronic Obstructive Pulmonary Disease (COPD) phenomenon rapidly converting into chronic significant health issues for many young adults. A disease calculated for older age gives way to early-onset COPD, which creates new issues for diagnosing and treating the illness and even interacts with the quality of life. The article reviews the epidemiology, risk factors, pathophysiology, clinical presentation, and treatment considerations related to this set of conditions. From those risk factors, early-onset …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 08–19 Read article →
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Published Subscription Review Article
RP-HPLC Analytical Method Development and Validation for Quantitative Estimation of Metoclopramide Hydrochloride in Solid Oral FormulationsBy Mayur Sudhakar Patil, Kamalesh Mistry, Dhananjay Mistry, Shivam Rongpi, Pratyush Kumar Brahma, Mitul Bhoi
Abstract: RP-HPLC technique formulated for the numerical assessment of Metoclopramide Hydrochloride in tablet formulation has been confirmed for reliability. A C18 column facilitated the chromatographic separation using a mobile phase comprising 60:40 (v/v) potassium dihydrogen phosphate buffer: meth anol mixture. Such method was used to detect, where the retained time was 6.78 minutes and Metoclo pramide Hydrochloride produced a clear peaked at 273 nm. Results were in agreement with ICH Q2 …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 07–15 Read article →