STM Journals Peer-reviewed research from Consortium e-Learning Network

Research & Reviews: A Journal of Drug Formulation, Development and Production Original Research

Development and Optimization of Orally Disintegrating Tablets (ODTs) Containing Standardized Curcumin Extract for Enhanced Bioavailability and Patient Compliance

  1. Rupesh Kumar Pandey Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh
  2. Kamalesh Mistry Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh
  3. Dhananjay Mistry Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh
  4. Shivam Rongpi Department of Pharmacy, Faculty of Pharmaceutical Science, Mewar University, Gangrar, Chittorgarh
  5. Pratyush Kumar Brahma School of Pharmacy, Rai University, Dholka, Ahmedabad
  6. Mitul Bhoi School of Pharmacy, Rai University, Dholka, Ahmedabad

Abstract

This research centers on creating and perfecting orally disintegrating tablets with standardized curcumin extract to both increase its bioavailability and promote better patient adherence. Although curcumin has numerous therapeutic applications. It remains clinically ineffective due to its poor aqueous solubility and bioavailability constraints. The development of orally disintegrating tablets involved direct compression with various levels of superdisintegrants including sodium starch glycolate and cross povidone to address existing challenges. Research teams developed five distinct formulations known as F1–F5 and conducted evaluations on pre-compression parameters together with postcompression quality attributes as well as in vitro disintegration, drug release, and short-term stability. Batch F5 outperformed all other samples by achieving a disintegration time of 27 ± 1 seconds and releasing 94.1 ± 0.8% of the drug within 30 minutes. All powder blends exhibited optimal flow properties while each tablet successfully met the required pharmacopeial standards. Accelerated storage condition tests demonstrated the optimized batch-maintained stability. The results indicate standardized curcumin extract ODTs using crospovidone as superdisintegrants offer a beneficial delivery method that improves curcumin’s therapeutic effects in patients facing swallowing challenges.This research centers on creating and perfecting orally disintegrating tablets with standardized curcumin extract to both increase its bioavailability and promote better patient adherence. Although curcumin has numerous therapeutic applications. It remains clinically ineffective due to its poor aqueous solubility and bioavailability constraints. The development of orally disintegrating tablets involved direct compression with various levels of superdisintegrants including sodium starch glycolate and cross povidone to address existing challenges. Research teams developed five distinct formulations known as F1–F5 and conducted evaluations on pre-compression parameters together with postcompression quality attributes as well as in vitro disintegration, drug release, and short-term stability. Batch F5 outperformed all other samples by achieving a disintegration time of 27 ± 1 seconds and releasing 94.1 ± 0.8% of the drug within 30 minutes. All powder blends exhibited optimal flow properties while each tablet successfully met the required pharmacopeial standards. Accelerated storage condition tests demonstrated the optimized batch-maintained stability. The results indicate standardized curcumin extract ODTs using crospovidone as superdisintegrants offer a beneficial delivery method that improves curcumin’s therapeutic effects in patients facing swallowing challenges.

Keywords

References (16)

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