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185 articles for “immune T cells”
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Canine Ehrlichiosis and Its Diagnostic Techniques: Review
Abstract: Canine monocytic ehrlichiosis, caused by Ehrlichia canis is one of the important immuno-suppressive infectious vector-borne diseases of dogs. Importantly, canine ehrlichiosis can be caused by different Ehrlichia species, which are intracellular rickettsial organisms belonging to the order Rickettsiales and included in the family Rickettsiaceae. Ehrlichias are the obligate intracellular organisms that affects the host immunologic response. It is typically a disease of leukocyte and platelet manifested by an acute reduction …
Published in Research and Reviews : A Journal of Immunology · Vol. 10, Issue 1, 2020 · pp. 1–11 Read article
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A Case with T-Cell Large Granular Lymphocyte Leukemia Accompanied with Persistent neutropenia without Anemia and Thrombocytopenia
Abstract: AbstractWe report a case of T-cell large granular lymphocyte (T-LGL) leukemia accompanied with persistent neutropenia without anemia and thrombocytopenia. A 47-year-old man was diagnosed as T-cell large granular lymphocyte leukemia by clinical feature, a persistent increase in the number of peripheral blood large granular lymphocyte and immune his to chemical analysis. He had the recurrent aphthous stomatitis persisting for more than 1 year. He showed neither lymph node swelling and …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 2, 2020 · pp. 24–28 Read article
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Nutrient-Mediated Activation of Cellular Signaling Pathways: Mechanistic Insights into Attenuation of Toxin Induced Inflammation in Food Animals
Abstract: Dietary and environmental toxins remain a persistent challenge in food animal production, where subclinical and clinical inflammation compromises health, productivity, and food safety. Toxin induced inflammation is driven by oxidative stress, mitochondrial dysfunction, and dysregulated immune signaling, resulting in impaired metabolic efficiency and increased disease susceptibility. Recent advances in nutritional science have revealed that nutrients act not only as substrates for growth but also as signaling molecules capable of modulating …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 1–12 Read article
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Vitamin D Mitigates Inflammation and Downregulates Importin α3 in Non-Alcoholic Fatty Liver Disease (NAFLD)
Abstract: Background: Pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IL-8, seem to play a crucial role in the progression of NAFLD as they activate the transcription factor NF-кB. The activated NF-кBp50/RelA subunits are translocated to the nucleus by Importin α3 and Importin α4. Numerous studies have indicated a negative association between NAFLD and vitamin D levels. Low vitamin D levels have been correlated with histological severity, necro-inflammation, and fibrosis in …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 1–16 Read article
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Rheumatoid Arthritis and Stem Cell Therapies Perspectives for It
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by systemic inflammation, primarily affecting synovial joints, leading to joint destruction and systemic complications. The pathogenesis involves immune system dysregulation, autoantibody production, and enzymatic imbalances. Enzymes, including matrix metalloproteinases (MMPs), serine proteases, and kinases, play crucial roles in these processes. Their dysregulation contributes significantly to disease progression through the imbalance of pro-inflammatory cytokines, oxidative stress, and extracellular matrix (ECM) degradation. MMPs, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
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Development of Zinc Gluconate Vitamin C Effervescent Tablet for Immunity Improvement and Management of Corona Virus Disease (COVID-19)
Abstract: The global pandemic of coronavirus disease- 2019 (COVID-19) continues to pose a threat to people, societies, and economic and healthcare systems. COVID-19s progression and lethality are determine by the host immune system, as is the case with many other diseases. revolutionary idea that has been used to treat other diseases is the control of inflammatory response and cytokine production based on immunonutrition. Some COVID-19 clinical trials are now using zinc, …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 2, 2022 · pp. 4–11 Read article
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Effects of Gypsophila on Airway Inflammation in Guinea pig model of ovalbumin‐induced Asthma
Abstract: To look at how Gypsophlia (GSP) affects airway inflammation in a model of ovalbumin-induced asthma in guinea pigs (OVA).Methods: Using a random number table, sixty healthy female guinea pigs were split into six groups, each consisting of ten rats: the normal control, OVA, and GSP (0.45, 0.9, 1.8, and 3.6 g/kg). The ovalbumin and lipopolysaccharide sensitization approach was used to create the OVA guinea pig model. The GSP groups received …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 17–23 Read article
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Phyto Biotics in Aquaculture
Abstract: This paper aims to assess the existing knowledge on the use and effects of phytobiotics in fish farming, as well as their potential for broader application in aquaculture. With the rising demand for fish, there has been a noticeable decline in fish production in recent years, which could be a driving factor behind the increasing interest in using phytobiotics in this field. The main factor contributing to the decrease in …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 13, Issue 2, 2024 · pp. 18–22 Read article
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Section Cutting in Histopathology: An Update
Abstract: Histopathology is the microscopic examination of tissues to diagnose and study diseases, more significantly the diagnosis of cancer. It plays a pivotal role in modern medicine, serving as the gold standard for definitive diagnosis in a wide range of conditions. Through meticulous analysis of tissue morphology (structure) and cellular characteristics, histopathology provides crucial information for disease classification, staging, and guiding patient management. In the world of histopathology, where microscopic details …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 1, 2024 · pp. 29–34 Read article
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Living with Glucose-6-Phosphate Dehydrogenase Deficiency
Abstract: Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is an X-linked recessive hereditary disease characterized by abnormally low levels of glucose-6-phosphate dehydrogenase, a metabolic enzyme involved in the pentose phosphate pathway, especially important in red blood cell metabolism. G6PD deficiency is the most common human enzyme defect. Individuals with this disease may exhibit non-immune hemolytic anemia in response to a number of causes, most commonly infection or exposure to certain medications or fava …
Published in Journal of Nursing Science & Practice · Vol. 6, Issue 1, 2016 · pp. 23–30 Read article
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An Update on HIV-2 Infection
Abstract: Human immunodeficiency virus type 2 (HIV–2) infection is an important cause of disease in a number of regions of the world. But the knowledge about this infection is sparse. Prevalence data on HIV-2 is heterogeneous. HIV-2 has a lower infectivity than HIV-1 which can be related to the lower RNA levels in this virus. The rate of progression to Acquired Immunodeficiency Syndrome (AIDS) in HIV-2-infected patients is highly variable making …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 2, 2018 · pp. 34–42 Read article
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When the Science Bridges the Efficacy and Safety: A Story of Psoronorm Cell Repair Oil
Abstract: Special cosmetic formulations are meant for certain unique benefits that are linked closely with therapeutic effect and hence such formulations require high level of safety considerations. The cosmetic formulations meant for Psoriasis type conditions need to be very safe as the skin of psoriatic patients is very sensitive. More over the Psoriasis is an auto immune disease and the products for these should not have the potential for irritancy. The …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 7, Issue 1, 2018 · pp. 42–44 Read article
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Vaccine Candidates and Animal Models for Kala-Azar
Abstract: Kala-azar or Visceral Leishmaniasis (VL) is a serious human disease in tropical regions and rapidly emerging as an opportunistic infection in HIV patients. The available treatment against VL is associated with toxicity and drug resistance. Even though the development of vaccines against VL is received limited attention. The only successful immunization strategy in humans has been leishmanization, which is based on the development of durable immunity after recovery from infection …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 1, 2015 · pp. 29–35 Read article
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Hematopoietic Stem Cells: Sources and Therapeutic Potential for Autoimmune Diseases and Cancer
Abstract: Hematopoietic stem cells (HSCs) are a group of multipotent adult stem cells that are responsible for lifelong production of all types of functional blood cells comprising myeloid (monocytes, macrophages, granulocytes), megakaryocytes/platelets, red blood cells (erythrocyte), T-cells, B-cells, natural killer (NK) cells, mast cells and dendritic cells (DCs). HSCs have the capacity for self-renewal and differentiation into various tissues. These remarkable properties of HSCs make them an ideal tool for tissue …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 1, Issue 3, 2012 · pp. 6–14 Read article
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DMARDs, Biologic Agents and Novel Experimental Strategies in The Treatment of Rheumatoid Arthritis
Abstract: An inflammatory and autoimmune disease, rheumatoid arthritis (RA) causes severe pain and inflammation in affected areas of the body. According to the report, there is no known cure for RA. Therefore, reducing discomfort and halting future harm must be the goals of present therapy. For the purpose of prevention and to reduce disease activity in RA patients, significant success has been achieved with the continued development of disease-modifying antirheumatic drugs …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 14–24 Read article
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Harnessing Honeybee Venom For Cancer Treatment: A Natural Remedy In Oncology
Abstract: Honeybee venom (HBV) has harvested significant attention as a promising natural compound with therapeutic potential in cancer treatment. This review investigates deeply into the current scientific understanding of honeybee venom, focusing on its anticancer mechanisms, molecular interactions, and potential clinical applications. Honeybee venom comprises various bioactive components, including melittin, apamin, phospholipase A2, and other peptides, which exhibit a wide range of biological activities. Recent research has demonstrated its ability to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 10–14 Read article
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Anaphylaxis: Pathophysiology, Risk Factors, and Clinical Management
Abstract: Anaphylaxis is a syndrome characterized by broncho-constriction, vasodilatation, and hypovolemia, potentially fatal exposure to known or unknown antigens. It can be an immune-mediated (IgE & non-IgE) disease. Immunoglobulin G (IgG), complement related (C3a/C5a), bradykinin, leukotrienes, prostaglandin E2, and ligands of certain G-protein coupled receptors (GPCR) can directly activate mast cells, basophils, eosinophils, neutrophils, endothelial cells and smooth muscles. Serum tryptase level during episodes of anaphylaxis, skin test, and basophil activation …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 2, 2025 · pp. 1–11 Read article
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Mast Cell Activation Disorders: Diagnosis & Management
Abstract: Mast Cell Activation Disorder (MCAD) is a broad umbrella term which includes a heterogenous group of disorders characterized by the inappropriate and excessive release of mediators from mast cells. Mast Cell Activation Syndrome represents a severe and well-defined form within the broader spectrum of Mast Cell Activation Disorders. These disorders are generally divided into clonal and non-clonal categories. Clonal conditions include Systemic Mastocytosis, Cutaneous Mastocytosis, and Monoclonal Mast Cell Activation …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 2, 2026 · pp. 31–40 Read article
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Carboxymethyl Cellulose-Based Spray-Dried Microspheres: Recent Advances and Applications in Targeted Drug Delivery Systems
Abstract: Microspheres are spherical particles ranging from 1 to 1000 μm, made from natural or synthetic polymers and inorganic materials. Their structure allows precise drug delivery, improving targeted release and minimizing off-target effects. Natural polymers such as starch, chitosan, and alginate are favored for their biodegradability, adhesion, and compatibility, enhancing mucosal interaction and residence time. Microspheres are widely used in site-specific drug delivery, gene therapy, and vaccine administration, improving immunogenicity, extending …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 251–268 Read article
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The Multifaceted Vitamin B6: Metabolism, Cardiovascular Health, Cognition, and Cancer
Abstract: Vitamin B6 is hydrophilic and plays a crucial role in various metabolic processes. It acts as a cofactor in different enzymatic reactions. Vitamin B6 exists in various forms, including pyridoxal 5'-phosphate (PLP), the most active form. Vitamin B6 is essential for amino acid metabolism, such as PLP is essential for transamination, the process of transferring amino groups between amino acids. This is vital for synthesizing non-essential amino acids and breaking …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 14, Issue 2, 2025 · pp. 33–39 Read article