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130 articles for “structural biology”
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Pharmacodynamics and Drug–Receptor Interactions: Integrating PK/PD Modeling with Modern Drug Development
Abstract: Understanding drug action requires an integrated perspective of pharmacodynamics and pharmacokinetics, which together determine therapeutic efficacy and safety. This review provides a comprehensive overview of the mechanisms underlying drug action, with particular emphasis on drug–receptor interactions and their role in modulating physiological responses. Drugs exert their effects primarily through interactions with specific biological targets, including receptors, enzymes, ion channels, and transporters, resulting in a spectrum of desired and adverse outcomes. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Systematic Analysis of the Pharmacological Properties of Different Plant Parts of Madhuca sp.
Abstract: Madhuca sp., a perennial tree belonging to the Sapotaceae family, are widely distributed across South and Southeast Asia. It holds considerable value across the food, beverage, and pharmaceutical sectors. The growing interest among cultivators, agronomists, and industry stakeholders stems from the diverse bioactive potential documented across different parts of the plant, including the bark, leaves, seeds, and flowers. Traditional and emerging evidence points to a wide spectrum of pharmacological actions, …
Published in Research & Reviews : Journal of Botany · Vol. 15, Issue 2, 2026 Read article
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Metagenome-Informed Engineering of Monoclonal Antibodies: Mining Microbial Immunoglobulin-Like Domains for Ultra-Stable Therapeutics
Abstract: Metagenome-informed engineering represents an emerging strategy for improving the stability and functionality of monoclonal antibodies (mAbs) by leveraging the vast diversity of microbial immunoglobulin-like (Ig-like) domains (10,24). These domains, derived from uncultured bacteria and bacteriophages, exhibit exceptional thermostability, protease resistance, and structural resilience due to adaptation to extreme environments (29,30). This review highlights advances in metagenomic mining, structural characterization, and protein engineering that enable the integration of microbial Ig-like scaffolds …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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An Overview on Quantum dot technology in Temperature sensor design
Abstract: Quantumdot (QD) thermometry harnesses the sizedependent electronic structure of semiconductor nanocrystals to translate minute temperature variations into robust optical signals. In this work we present a systematic design framework for QDbased temperature sensors that integrates (i) bandgap engineering through precise colloidal synthesis, (ii) surfacestate passivation to suppress nonradiative pathways, and (iii) a planar photonicreadout architecture compatible with lowcost, CMOSfriendly fabrication. By exploiting the linear redshift of the photoluminescence (PL) peak …
Published in Journal of Electronic Design Technology · Vol. 17, Issue 1, 2026 · pp. 10–17 Read article
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Characterization and Antimicrobial Investigations of Isomeric Pr(III) Juglonates
Abstract: Hydroxy napthoquinone derivatives constitute an interesting group of ligands which is recognized as ‘Juglones’. Isomeric Lawsone-Juglone and Phthiocol-Plumbagin are the most important members of the Juglone series and are biologically active, having natural origin. They form isomeric pairs of ligands resulting into isomeric pairs of metal chelates. The isomerism is occurring due to formation of either five or six membered rings in the metal chelates. In the present work Prasodymium …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 545–552 Read article
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Biodegradable Polymers Properties and Applications
Abstract: Polymers that can degrade into biologically compatible components under physiologic conditions present a far more attractive alternative for the preparation of drug delivery systems. The use of biodegradable polymers precludes the need for retrieval at the conclusion of the dosing regimen, thereby avoiding the potential complications associated with the use of non-degradable systems. A wide variety of approaches are continuously being pursued in the quest for improved biodegradable drug delivery …
Published in Trends in Drug Delivery · Vol. 8, Issue 2, 2023 · pp. 57–72 Read article
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Topology and Geometry in Data Science: Persistent Homology and Beyond
Abstract: In recent years, the interplay between topology, geometry, and data science has gained substantial momentum, offering powerful frameworks to analyze and interpret complex datasets. Traditional statistical and machine learning methods often rely on linear or metric- based assumptions, which may fail to capture the intrinsic structure of high-dimensional or nonlinear data. In contrast, topological and geometric methods provide shape-oriented, scale- invariant tools that focus on the continuity, connectivity, and global …
Published in Recent Trends in Mathematics · Vol. 1, Issue 2, 2024 · pp. 21–27 Read article
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Nutrition Induced Remodeling Dynamics of Cell Membranes: Implications for Performance, Health, and Welfare Issues in Food Animals
Abstract: Cell membranes represent dynamic structural and functional platforms that integrate nutritional signals with cellular metabolism, immune competence, and physiological adaptation in food animals. Beyond their classical role as selective barriers, membranes actively regulate nutrient transport, signal transduction, and bioenergetics through highly responsive lipid and protein networks. Dietary components, particularly fatty acids, vitamins, minerals, amino acids, and bioactive compounds, critically influence membrane composition, fluidity, and stability, thereby shaping cellular function and …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 25–37 Read article
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The Effects of Physiochemical Parameters and Microbial Counts on Metal Coupons Corrosions in Freshwater Environment at Different Water Depths
Abstract: The effect of water quality on metal coupon corrosion was investigated at the New Calabar River in Choba. The study examined metal corrosion rates at five different depths: 30 cm, 60 cm, 90 cm, 120 cm, and 150 cm in a freshwater environment. Water samples were collected at each depth and analyzed for physicochemical and microbial parameters to understand their impact on metal degradation. Key parameters measured included pH, Electrical …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 2, 2025 · pp. 31–51 Read article
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The Role of Soil Quality Parameters in Enhancing Agricultural Productivity
Abstract: Thus one can define soil quality as a set of physical, chemical and biological properties of the surface layer of the Earth’s crust that affects agriculture production. In this study, some of the factors which are related to soil quality include pH, texture, organic matter content, nutrient availability and microbial activity that affect crop germination as well as yield. It looks at the way in which the soil factors influence …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 14, Issue 3, 2025 · pp. 48–66 Read article
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Exploring Carbon Nanotubes in Nanotechnology: Functional Properties, Surface Modifications, and Biomedical Innovations
Abstract: Significant progress has been made in nanotechnology in recent years, especially in the creation of sensors with a broad range of uses. Among these, carbon nanotubes (CNTs) are cylindrical structures composed of carbon, with diameters in the nanometer range. CNTs originate from graphite sheets, where the graphite layers resemble a rolled-up, continuous, and robust hexagonal mesh. These hexagons have carbon atoms at their vertices. The fabrication of CNTs typically involves …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 2, 2024 · pp. 24–31 Read article
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The Dental Pulp: Vital Core of Tooth Functionality
Abstract: Dental pulp, an intricately specialized mesenchymal tissue, possesses limited regenerative capabilities attributable to the unique anatomical arrangement and the post-mitotic nature of odontoblastic cells. The process of complete pulp amputation, subsequent disinfection of the pulp space, and the insertion of synthetic materials results in the substantial loss of dentin, leading to enduring consequences such as a non-vital and structurally weakened tooth.Nevertheless, a beacon of hope emerges in the form of …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 1, 2024 Read article
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Investigation of Bio-Physical Interaction and Electrophoretic Properties of Fe3O4/DNA Nanocomposite and Colloids for Biomedical Application
Abstract: In recent years, research on magnetic nanoparticles has gained significant attention. The core concept behind their physics lies in their interaction with biomolecules such as hemoglobin, DNA, and RNA. This study examines the fundamental forces involved in these interactions, including van der Waals attractions, electrostatic repulsion, thermal effects, and magnetic coupling between nanoparticles and biological molecules. To describe these interactions quantitatively, parameters such as zeta potential, magnetic moment density, and …
Published in Research & Reviews : Journal of Physics · Vol. 14, Issue 3, 2025 · pp. 20–32 Read article
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A Comprehensive Study of ZnxFe2-xO3 Nanoparticles: Assessing Magnetic Properties for Medical Imaging (MI)
Abstract: Diluted magnetic ZnxFe2-xO3 nanoparticles are special semiconducting nanoparticles which are recognized for their magnetic properties. A theoretical examination of Zn-doped αFe2O3 nanostructures reveals a range of structural and property variations, offering insights into their potential applications and behavior at the nanoscale. In this regard, Heisenberg’s model and Weiss molecular filed theory is used to describe the magnetic properties of ZnxFe2-xO3 nanoparticles. These theorems inevitably enable to investigate the relationship between …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 26, Issue 2, 2024 · pp. 18–25 Read article
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A Study to Evaluate Mothers’ Perceptions and the Effectiveness of an Awareness Program Aimed at Enhancing Knowledge About Behavioral Issues in Primary School Children Within a Specific Community in Haldwani, Uttarakhand
Abstract: Background: Behavior is perceived in society as how an individual presents themselves in various situations. As a child grows, their development encompasses biological, psychological, and emotional changes that occur from birth. The parent-child relationship also evolves through daily, reciprocal interactions in different relational domains, such as attachment and authority, which lay the foundation for future interactions. These exchanges can significantly influence a child’s development across various areas, including emotional, physical, …
Published in International Journal of Community Health Nursing And Practices · Vol. 2, Issue 2, 2024 · pp. 9–13 Read article
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An Overview of New Coastal Research Vessel (N-CRV) Dry Dock and Construction
Abstract: A New Coastal Research Vessel (N-CRV) is a specialized ship designed for scientific research in fields like oceanography, geology, biology, and atmospheric studies, equipped with specific facilities and accommodations for sea missions. This paper discusses the coastal research ship dry-dock, construction, and design process, which involves three stages: concept, preliminary, and contract design. N-CRV must utilize scientific cruise, Exclusive Economic Zone (EEZ) survey, deployment, data collection, and seawater sample collection …
Published in Journal of Offshore Structure and Technology · Vol. 11, Issue 3, 2024 · pp. 1–11 Read article
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Synthesis, Antibacterial Evaluation and Antifungal Study of New Biochemical Derivatives
Abstract: Bacterial and fungal infections have become widespread recently due to the spread of epidemics, diseases, and bacterial infections. As a result, infection rates have increased, prompting many researchers to develop new antibiotics to reduce the spread of these prevalent diseases. Researchers have prepared biochemical compounds similar in structure to drugs that eliminate infections and reduce their spread. One such derivative is imidazole; a well-known compound used in many medications for …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 1, 2026 · pp. 19–28 Read article
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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Biobased Composite Materials for Sustainability
Abstract: Due to increasing demand for sustainable materials in various industrial sectors has directed a significant interest in biobased composite materials. Biobased materials, derived from biological resources, offer a promising substitute as compared to conventional composites that rely greatly on fossil fuels. This paper explores the advanced applications of biobased composites across various sectors such as automotive, construction, packaging etc., emphasising their potential to reduce environmental impact while maintaining the standard …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 163–170 Read article
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Recent Advancements in Nanobiocomposite-Based Wound Healing and Tissue Regeneration
Abstract: Haemostasis, inflammation, proliferation, remodeling, and other highly coordinated cellular and molecular activities are all part of the complex biological processes of wound healing and tissue regeneration. Following an injury, these stages cooperate to restore tissue integrity and function. However, this normal process is disturbed in many clinical circumstances, especially chronic wounds such diabetic ulcers, burns, and pressure sores. Prolonged inflammation, chronic microbial infection, diminished angiogenesis, and impaired extracellular matrix production …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 297–318 Read article