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206 articles for “ACE 2”
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Formulation And Evaluation Of Captopril Sustained Release Tablet By Qbd Approach.
Abstract: The purpose of present study was to formulation and evaluation of Captopril sustained release tablet by QbD approach using size expanding polymer and cross linker. Captopril is a ACE inhibitor use in treatment of mild to moderate hypertension. Captopril having biological half-life of 2 hrs. The drugs gets degrade as its goes to higher pH, so we selected size expanding GRDDS. In formulation development study by using QbD, we found …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 10, Issue 1, 2023 · pp. 64–73 Read article
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Evaluation of Anthelmintic, Analgesic and Neuropharmacological activity of Heliotropium indicum
Abstract: The present study was performed to evaluate the anthelmintic, analgesic and neuropharmacological activity of the methanol extract from the leaves of Heliotropium indicum. Anthelmintic activity was investigated using earthworm (Pheretima posthuma) & fresh leaf juice of the plant. In anthelmintic activity test, the time of paralysis for fresh juice was range from 7 min 55 s to 26 min 55 s whereas the time ranges for standard drug albendazole was …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 9, Issue 1, 2019 · pp. 31–38 Read article
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Mono(acetylacetonato)zirconium(IV) Aryloxides: Synthesis, Reactivity and Thermoanalytical Investigation
Abstract: Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 A series of novel zirconium(IV) complexes, formulated as ZrCl3−n(acac)(OArI–V)n (where n =− 3; –OArI = OC6H4Cl-2, –OArII = OC6H4Cl-4, –OArIII = –OC6H3Cl2-2,4, OArIV = –OC6H3Cl2-2,6 and OArV = –OC6H2Cl3-2,4,6) were synthesized by reacting ZrCl3(acac) with corresponding substituted chlorophenols in separate experiments. The complexes were characterized by elemental analysis, molar conductance measurements, molecular weight determination, spectroscopic techniques (1HNMR and IR) and thermal …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 3, Issue 1, 2012 · pp. 6–16 Read article
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Synthesis and Chemical Characterization of Novel Series of Benzoxazinone Derivatives
Abstract: The objective of the current work is to synthesize some novel benzoxazinone derivatives and to study their antibacterial activity in particular. Thus an effort has been made in this direction. The antimicrobial activity of the synthesized some novel benzoxazinone derivative is summarized.As estimated, benzoxazinone derivatives exhibited significant to moderate antimicrobial activity. Therefore, a detailed study of toxicity is necessary. Heterocycles formed the sites of reactions in many enzymes or co-enzymes. …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 3, 2018 · pp. 41–57 Read article
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A New Separation Technique for Method, Development and Validation of Aclidinium Bromide and Formoterol Fumarate in Its Pure and Pharmaceutical Dosage Form by Using Rp-HPLC
Abstract: A new simple, precise, selective and accurate, a new method of development and validation using Rp-HPLC for the estimation of Aclidinium bromide and Formoterol Fumarate in its pure and pharmaceutical dosage form. Chromatogram was run through DIKMA Spursil, C18 segment (4.6×150 mm, 5µ0). Mobile phases contain 0.1% OPA: Acetonitrile (30:70) with the use of the 0.1% OPA buffer, stream rate of 1 ml/min and measured in 280 nm. The run …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 18–36 Read article
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Investigation of Annonaceae Acetogenins for Inhibition of Dengue Viral Protease using in silico Docking Studies
Abstract: Dengue viruses (DENVs) cause severe and widespread epidemics of diseases such as dengue fever and dengue hemorrhagic fever/dengue shock syndrome. Unfortunately, there is at present neither prophylaxis nor specific treatment to cure the disease and thus it is need of the hour to develop new antiviral therapeutic agents to combat diseases caused by DENV. Non-structural protein NS3 play a major role in the processing of polyprotein and replication of the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 47–52 Read article
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Effect of Bone Marrow Derived Autologous Stem Cell Transplantation on Cerebral Metabolism of a 20-year-old Autistic Patient
Abstract: Autism is a neurodevelopmental disorder characterized by clinically significant impairment in social, occupational and other important areas of normal functioning. The autistic brain shows altered neurochemical metabolism, such as decreased glucose uptake, increased concentrations of lactate and reduced concentrations of N-acetyl-aspartate. Besides behavioral therapies and medications for autism-associated conditions such as seizures and gastrointestinal distress, there are no U.S. FDA approved pharmacological therapies to treat Autism’s core pathology. Stem cell …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 3, Issue 3, 2013 · pp. 14–20 Read article
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Acetylcholinesterase and Butyrylcholinesterase Activities in Brain and Plasma of Several Species of Birds in India
Abstract: Since timely acquisition of concurrent controls is not always feasible, development of a reference data of normal cholinesterase (ChE) activities for various wildlife species particularly for birds is necessary to diagnose anticholinesterase exposure. In the present study, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities in brain and plasma of several species of birds collected from Ahmedabad, India, during 2005–2007, were determined. Brain AChE activity ranged from 1.24 µmole/min/g in Indian white-backed …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 1, 2012 · pp. 1–9 Read article
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Candida albicans: In vitro Inhibition of Morphological Transition by Analgesic Compounds
Abstract: This study aimed to investigate, in vitro, the effect of some analgesic compounds, which inhibit the activity of cyclooxygenase isoenzymes, on the morphological transition of Candida albicans from unicellular budding yeast to a filamentous form. C. albicans ATCC 10231 cultured in Sabouraud’s dextrose broth supplemented with 20% human serum for 72 h at 30 °C in the presence or absence of tramadol of HCl, ketorlac tromethamine, piroxicam and acetaminophen at …
Published in Research and Reviews: A Journal of Medicine · Vol. 3, Issue 3, 2013 · pp. 11–15 Read article
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Screening of Phytochemicals and Antibacterial Potential of Dicranopteris linearis (Burm.f.) Underw.
Abstract: The present study deals with screening of phytochemical and antibacterial potential of terrestrial fern Dicranopteris linearis (Burm.f.) Underw. collected from Marthandam region of Kanyakumari district of Tamil Nadu, India. The fresh plant material was collected and shade dried for a week and powdered. The powdered material was subjected to gradient extraction with Soxhlet apparatus with two different solvents (acetone and chloroform) and screened for its phytochemical and antibacterial potential. Phytochemical …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 10, Issue 3, 2020 · pp. 1–5 Read article
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Can Screw-only fixations of ACPHT acetabular fractures enhance stability as the standard buttress plate fixation provides?
Abstract: Background: Of acetabular fractures, anterior column posterior hemi-transverse(ACPHT) fractures commonly occur after a fall onto the hip in elderly population. When displaced in these fractures, open reduction and internal fixation using plate and screws is usually required to achieve good functional outcomes. The open procedures, however, involve high complication rates due to surgical invasion; therefore, percutaneous techniques by screw-only constructs have been advocated to minimize these complications. The purpose of …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 64–73 Read article
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Extraction and Purification of Total Phenolic Content from Combination of Seeds and Peel of Cucurbita
Abstract: Phenolic compounds are belonging to secondary metabolites and played an antioxidant and anti-cancer properties. In the Soxhlet extraction process, the extraction of total phenolic content concentration was 28.0µg/ml obtained from combination of seeds and peel of of Cucurbita at 4 hr. This extract was drawn in to the Column chromatography and its concentration was increased to 34.0µg/ml. The purity of phenolic content was improved by column chromatography at 40 min. …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 9, Issue 1, 2019 · pp. 1–3 Read article
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Analysis of Diethanolamide Reaction by using FTIR Technique
Abstract: The purpose of this work is to study the amidification reaction for production of diethanolamide from ethyl acetate and diethanolamine by using sulfuric acid catalyst. The amidation, which is the reaction between ethyl acetate and diethanolamine, was held in a glass batch reactor with mole ratio 1:1 using acid catalyst (H2SO4) 0.5% (w/w) and 200 rpm stirring. The reaction temperature is 160°C constant, and sampling was performed after every 30 …
Published in Journal of Catalyst & Catalysis · Vol. 3, Issue 1, 2016 · pp. 7–10 Read article
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New RP-HPLC Method Development and Validation for Simultanious Estimation and Forced Degradation Studies of Gallic acid and Curcumin in Solid Dosage Form
Abstract: Objective: A New method was established for simultaneous estimation of Gallic acid and curcumin by RP-HPLC method. Methods: Chromatographic separations were performed on an Inspire (4.6 x 150mm, 5m) column with a mobile phase composition of 0.1 percent OPA buffer and Acetonitrile (30:70) delivered at a flow rate of 1 ml/min, and detection was performed on a waters HPLC auto sampler, separation module 2695 with PDA detector 2996 at wavelength …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 1, 2022 · pp. 7–15 Read article
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Synthesis and Biological Evaluation of Mannose Thiazolidinones
Abstract: In a one pot procedure, a series of novel mannose thiazolidinone derivatives 4a–g and 5a–g were prepared by condensation of (3aS, 4S, 6S, 6aS)-6-methoxy-2,2-dimethyltetrahydrofuro [3,4-d][1,3]dioxole-4-carbaldehyde-3 with mercapto acids and primary amines in presence of ZnCl2 under both micro wave irradiation and conventional heating conditions. Compound-3 was prepared from Methyl di acetone D-Mannose with primary acetonide deprotection and with oxidative cleavage. Characterization of new compounds has been done by means of …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 2, 2018 · pp. 38–46 Read article
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Bioscouring And Anionization of Waste Cotton Fabric for Efficient Removal of Malachite Green Dye
Abstract: Adsorption is an efficient method for dye removal but the high cost of adsorbents limits its use, emphasizing the need for sustainable, low-cost alternatives. This study explores the usage of modified cotton fabric for the treatment of malachite green (cationic dye) from wastewater. Cellulase extracted from Raphanus sativus and Daucus carota were evaluated for bioscouring potential which was confirmed by scanning electron microscopy. Further, cotton fabric was chemically modified using …
Published in Journal of Water Pollution & Purification Research · Vol. 13, Issue 1, 2026 · pp. 53–68 Read article
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Anti-inflammatory Activity of Leaves Fractions of Traditionally used Medicinal Plants
Abstract: Traditional plants such as Amaranthus spinusus Linn and Abutilon indicum Linn have been used in the Indian traditional system of medicine for the treatment of several diseases such as pain, inflammation, piles, toothache etc. The fractions of ethyl acetate, methanol and ethanol were tested for their anti-inflammatory activity. Ethanolic and methanolic fractions of A. indicum and A. spinusus at the doses of 200 and 400 mg/kg produced highly significant activity. …
Published in Research and Reviews : A Journal of Immunology · Vol. 8, Issue 1, 2018 · pp. 34–36 Read article
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Evaluation for Diuretic Activity of Abutilon indicum and Amaranthus spinusus Leaves Extracts
Abstract: The diuretic activity of Abutilon indicum and Amaranthus spinusus leaves was studied. The fractions of ethanol and methanol showed significant increase in the urine elimination, while ethyl acetate fraction does not show diuretic activity. All the groups were compared to the control group; frusemide was used as reference standard drug in this screening activity. The phytochemical screening study showed the presence of flavonoids, saponins, terpenoids, and steroid content in both …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 2, 2017 · pp. 12–15 Read article
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Preparation and Structural Characterization of PVP-CH3COONa Based Polymer Films
Abstract: PVP based polymer electrolyte films were prepared by dissolving sodium acetate with different wt.% compositional ratios by solution cast technique. XRD revealed the crystalline phase of the prepared samples. XRD pattern demonstrated a wide peak at 29.35° attributed to the host polymer indicating orthorhombic cross section showing semicrystalline phase. FTIR and Raman studies affirmed to identify the functional group of the materials, bond formation between the dopant salt and the …
Published in Research & Reviews : Journal of Physics · Vol. 7, Issue 2, 2018 · pp. 25–31 Read article
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Anthelmintic, Neuropharmacological and Analgesic Activities of Extracts from the Aerial Part of Eclipta alba L.
Abstract: The current study was aimed to investigate the anthelmintic, neuropharmacological and analgesic activities of extracts from the aerial part of the plant Eclipta alba L. (Family: Asteraceae). The anthelmintic activity was performed by observing the time of paralysis and the time of death of earthworms Pheretima posthuma compared with the standard drug, albendazole. The range of minimum to maximum time of paralysis and death of albendazole at the conc. 100 …
Published in Research & Reviews : Journal of Herbal Science · Vol. 5, Issue 1, 2016 · pp. 1–5 Read article