In a one pot procedure, a series of novel mannose thiazolidinone derivatives 4a–g and 5a–g were prepared by condensation of (3aS, 4S, 6S, 6aS)-6-methoxy-2,2-dimethyltetrahydrofuro [3,4-d][1,3]dioxole-4-carbaldehyde-3 with mercapto acids and primary amines in presence of ZnCl2 under both micro wave irradiation and conventional heating conditions. Compound-3 was prepared from Methyl di acetone D-Mannose with primary acetonide deprotection and with oxidative cleavage. Characterization of new compounds has been done by means of IR, NMR, MS and elemental analysis. The nematicidal and anti-bacterial activity of the compounds has also been evaluated. Keywords: D-mannose, thiazolidinones, microwave assisted synthesis, antimicrobial and nematicidal activity Cite this ArticleAvula Srinivas, Md Aleempasha, Sudhaker Reddy V, et al. Synthesis and Biological Evaluation of Mannose Thiazolidinones. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2018; 5(2): 38–46p.
