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1260 articles for “CTLA-4”
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Immunotherapy Advancements in Cancer Treatment
Abstract: Immuno-oncology has been one of the more exciting developments in the field of cancer treatment since about a century ago, with William B. Coley's work in the late 19th century, which really gave the field its beginnings with "Coley's toxin." In an initial effort that proved unsuccessful, early immunotherapy approaches utilizing bacterial mixtures to induce immune responses against tumors nonetheless laid some groundwork for this field. It wasn't until over …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 22–28 Read article
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Experimental Evaluation of MDM@Gd2O3:Eu3+ and Protein@MDM@Gd2O3:Eu3+ Functional Nanomaterial
Abstract: Lanthanide cation like Eu3+ (europium Xe 4f66s0) doped functional nanomaterials of lanthanide oxides especially of gadolinium oxide (Gd2O3) as nanorods capped with monodispersed macromolecule (MDM) like polyvinylpyrrolidone (PVP) coated with natural biopolymers like proteins as human serum albumin (HSA) have been the most demanding and applied nanomaterials in areas of the biosensor, optical distinguisher, electronic fluoresces, upconversion, and surface plasmonic resonance (SPR) nanomaterials and others. The Gd3+ and Eu3+lanthanide cations …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 214–223 Read article
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Microwave-Assisted Synthesis of Li₃Ba₂Gd₃(MoO₄)₈ Phosphors Doped with Pr³⁺ and Sm³⁺ for High-Performance Red Emission in LED Applications
Abstract: In this study, we report the successful synthesis of Li₃Ba₂Gd₃(MoO₄)₈ (RE³⁺ = Pr³⁺, Sm³⁺) phosphors using a novel, microwave-assisted solid-state reaction method at ambient temperature. The synthesis involved the use of analytical grade reagents including Lithium Nitrate (LiNO₃), Barium Nitrate, Gadolinium Nitrate (Gd(NO₃)₃·6H₂O), Ammonium Molybdate ((NH₄)₆Mo₇O₂₄·24H₂O), and high-purity oxides of Praseodymium (Pr₂O₃) and Samarium (Sm₂O₃). The reagents were mixed in stoichiometric ratios, ground thoroughly in a pestle and mortar, and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 18–32 Read article
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Influence of Inter and Intra-Row Spacing on Hot Pepper (Capsicum Annum L.) Growth,Yield and Yield Component of Under Rain Fed at Guraferda and Gimbo, Southwest Ethiopia
Abstract: Inappropriate plant population density and other limitation factors are among the key reasons for the low hot pepper yield in Ethiopia, including South West Ethiopia. To increase the productivity of hot pepper use of appropriate population spacing is vital. Hence, a field experiment was conducted at Guraferda and Gimbo during the main rainy season to evaluate the response of hot pepper for growth and yield and yield components. A factorial …
Published in International Journal of Trends in Horticulture · Vol. 1, Issue 1, 2024 · pp. 4–9 Read article
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Evaluating the therapeutic effects of Asystasia gangetica (Chinese violet) on the chronic respiratory condition- Asthma
Abstract: Asthma is a chronic condition affecting the respiratory system. Its symptoms affect the immune pathways via helper T-cells. The plant Asystasia gangetica is prevalent throughout tropical regions around the world. It has been used in some herbal remedies to relieve symptoms of asthma. This study used computational techniques to assess the effectiveness of several phytocompounds present in A. gangetica in relieving symptoms of Asthma. Three proteins associated with asthma, namely …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 15–21 Read article
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Comprehensive Experimental Analysis of the Mechanical Properties and Enhancements of Natural Fiber Composites
Abstract: This research investigates the mechanical characteristics of bio-composites reinforced using jute and sisal fibers. Natural fibers have emerged as promising alternatives because of their low density, renewability, biodegradability and approving mechanical properties. The research involved fabricating bio-composite plates using the hand lay-up method with varying orientations of jute and sisal fibers. The mechanical parameters, including tensile strength, impact strength, and flexural strength, were rigorously assessed and compared across various fiber …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 45–53 Read article
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First Insights into Whole Genome Sequencing of the Mycobacterium tuberculosis Complex: Molecular Diversity and Drug Susceptibility Patterns in Senegal
Abstract: Background: We conducted a bibliographic analysis of the Mycobacterium tuberculosis complex (MTBC) in sub-Saharan Africa, which included the analysis of 8,139 genomic sequences from 34 of the 49 sub-Saharan African countries. Notably, only one complete sequence from Senegal was identified, which had been generated in the United States. Our primary objective was to utilize whole genome sequencing (WGS) to detect resistance in anti-tuberculous strains of the MTBC in Senegal. This …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 Read article
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Smart Bank Locker Security System
Abstract: This paper introduces a smart bank locker security system that aims to improve the reliability and security of locker access in banks. The system has a Raspberry Pi 4B as the controller, with face detection and fingerprint scanning used for dual-factor authentication. The fingerprint scanner and facial recognition unit identify the user's identity prior to access. After successful verification, a relay is triggered to open the locker. A liquid crystal …
Published in Journal of Electronic Design Technology · Vol. 16, Issue 2, 2025 · pp. 31–36 Read article
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Polymer Chemistry-Guided Development of Biomimetic Composite Scaffolds
Abstract: Polymer chemistry plays a fundamental role in advancing biomaterials for anatomical tissue engineering, particularly in the design of composite scaffolds that replicate the intrinsic characteristics of native tissues. The regeneration of damaged tissues, especially within anatomically complex structures such as bone, cartilage, and skin, necessitates biomaterials that closely emulate the hierarchical architecture and biological functions of native extracellular matrices (ECMs). The capacity to replicate both mechanical and biochemical cues of …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 7–13 Read article
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Voice Control Music System Using Raspberry Pi
Abstract: This paper presents a voice-controlled music system using Raspberry Pi, designed for hands-free music playback through voice commands. The system is implemented using Raspberry Pi 4B, a microphone, a speaker, and a 32GB SD card. The software is developed in Python using Thonny IDE, leveraging libraries such as SpeechRecognition, PyAudio, and gTTS for speech processing and audio playback. The system recognizes user commands like play, pause, next, and stop, converting …
Published in Journal of VLSI Design Tools and Technology · Vol. 15, Issue 2, 2025 · pp. 34–39 Read article
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The Role of Simulation and Digital Twins in Enhancing Mechanical Production Efficiency: A Systematic Review
Abstract: In the evolving landscape of smart manufacturing, simulation technologies and digital twin (DT) systems have emerged as pivotal tools for enhancing the efficiency, agility, and sustainability of mechanical production processes. This systematic review investigates how the integration of simulations and DTs contributes to performance improvements across various stages of mechanical manufacturing—ranging from design and process optimization to predictive maintenance and real-time monitoring. While simulations provide the ability to model, test, …
Published in Journal of Production Research & Management · Vol. 15, Issue 2, 2025 · pp. 31–36 Read article
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A Survey of Role-Based Access Control Implementation in HMI Systems for Industrial Automation
Abstract: The convergence of Role-Based Access Control (RBAC) and Human-Machine Interface (HMI) systems presents a transformative approach to secure and efficient industrial automation in Industry 4.0. By integrating RBAC with Multi-Factor Authentication (MFA), this framework enhances cybersecurity while maintaining operational flexibility, mitigating both external threats and internal vulnerabilities. Modern adaptive HMIs further optimize user experience through personalized and intuitive interfaces, though challenges remain in balancing functionality with simplicity in complex industrial …
Published in International Journal of Advanced Control and System Engineering · Vol. 3, Issue 2, 2025 · pp. 10–19 Read article
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Development of Lightweight Chassis and Efficient Drivetrain for Formula Student Applications
Abstract: The chassis and drivetrain of a Formula Student vehicle are designed, analyzed, and optimized in this research study with an emphasis on manufacturability, performance, and safety. The project emphasizes the use of advanced engineering tools such as SolidWorks for computer-aided design (CAD) and ANSYS for structural analysis to evaluate the chassis under various dynamic conditions. The primary objective is to ensure that the driver remains safe inside the cockpit while …
Published in Journal of Automobile Engineering and Applications · Vol. 12, Issue 3, 2025 · pp. 1–17 Read article
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Digital and Sustainable Innovations for Zero-Waste Manufacturing
Abstract: The integration of digital technologies and sustainable practices in manufacturing is crucial for addressing global issues like resource depletion, pollution, and waste. Zero-waste manufacturing has emerged as a transformative approach to minimize environmental impact and boost production efficiency. This paper explores how digital and sustainable innovations support this goal. Industry 4.0 technologies— such as IoT, AI, Big Data, and robotics—enable real-time monitoring, predictive maintenance, and optimized resource use. Sensors and …
Published in Journal of Control & Instrumentation · Vol. 16, Issue 3, 2025 · pp. 34–42 Read article
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Evaluation of Mechanical Properties of Arecanut Fiber Reinforced Epoxy Composite
Abstract: This study investigates the mechanical performance of arecanut fiber-reinforced epoxy composites, aiming to evaluate their potential for sustainable industrial applications. Arecanut husk fibers, an agricultural waste product, were selected for their natural abundance and biodegradability. To enhance fiber-matrix bonding, the fibers were chemically treated with sodium hydroxide (NaOH), which effectively removes lignin, hemicellulose, and other impurities, improving surface roughness and interfacial adhesion. The treated fibers were then incorporated into an …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 389–400 Read article
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Design and Analysis of Low-Power CMOS Inverter Chains for High-Speed Digital Circuits
Abstract: This report briefly explains the design process, structure, and evaluation of a CMOS inverter designed using a 45 nm technology process with a focus on its propagation delay and power consumption. Moreover, the CMOS inverter design will be created using the Cadence Virtuoso design environment, along with a post-layout analysis of the design. Performance evaluation of the designed circuit will be carried out through the execution of a transient analysis …
Published in Journal of VLSI Design Tools and Technology · Vol. 16, Issue 1, 2026 · pp. 40–57 Read article
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Autonomous Agentic AI for Adaptive Cure Optimization and Defect Prevention in Thermoset Polymer Composite Manufacturing
Abstract: Thermoset polymer composites occupy a central position in modern structural manufacturing, from aircraft fuselages to wind-turbine blades. Despite progress in resin chemistry and fiber architecture, the “cure process” that transforms compliant preforms into load-bearing structures remains difficult to manage. Manufacturers encounter ‘voids’, “interlaminar delaminations”, and “spring-back distortion” when curing complex or thick-section parts. The cause is not ignorance of the relevant physics, but rather that ‘temperature’, ‘chemistry’, ‘rheology’, and ‘mechanics’ …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 301–320 Read article
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Mechanical Performance Evaluation of Brachyuran Shell Particle-Infused S-Glass Fibre Epoxy Polymer Composites
Abstract: Epoxy composites bio-filled with brachyuran crab shell powder and reinforced with S-glass fibres at different loadings (2%, 4%, and 6%) are tested for their mechanical properties in this work. Using modest amounts of filler significantly improved hardness, ultimate tensile strength, and flexural strength in the empirical data. The largest increase in hardness was 64.42% at 4% filler, up from 26.22% at 2%; however, there was a dramatic decrease to 13.11% …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 500–507 Read article
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Sensors-Based Electric Machine Design for Industry
Abstract: The integration of advanced sensors is fundamentally changing the economics and reliability of electric machines. It moves design focus from minimizing material cost and adhering to conservative standards toward maximizing operational availability and energy efficiency. In the industry of tomorrow, the electric motor will not be a passive collection of coils and steel, but a self-diagnosing, self-optimizing, and perhaps even self-healing asset—a sentient motor—driven by its highly refined sixth sense, …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 4, Issue 1, 2026 · pp. 1–10 Read article
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The Integrity of Bio-Stimulant Efficiency of Mint Leaf (Mentha Piperita) on Crude Oil Remediation in Soil Environment
Abstract: This research addresses the integrity of biostimulant efficiency of mint leaf (Mentha piperita) on crude oil remediation in soil environments. The soil environment consideration in this investigation is loamy and some soil properties were examined; obtained data revealed a nitrogen value of 5.82%, phosphorus value of 46.91mg/kg, potassium value of 417.51mg/kg, and hydrogen-utilizing bacteria (HUB) value of 13.19cfu/g for unpolluted loamy soil, whereas polluted soil with crude oil data are …
Published in International Journal of Pollution: Prevention & Control · Vol. 4, Issue 1, 2026 · pp. 41–47 Read article