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Research and Reviews: A Journal of Toxicology Original Research

Evaluating the therapeutic effects of Asystasia gangetica (Chinese violet) on the chronic respiratory condition- Asthma

  1. Megha Majoe Department of Bioinformatics, BioNome | For Genomics and Bioinformatics Solution, Bengaluru

Abstract

Asthma is a chronic condition affecting the respiratory system. Its symptoms affect the immune pathways via helper T-cells. The plant Asystasia gangetica is prevalent throughout tropical regions around the world. It has been used in some herbal remedies to relieve symptoms of asthma. This study used computational techniques to assess the effectiveness of several phytocompounds present in A. gangetica in relieving symptoms of Asthma. Three proteins associated with asthma, namely IL-5, TRPA1 and IL1RL1, were selected. The phytocompound (1aR,4S,4aS,7R,7aS,7bR)-1,1,4,7-tetramethyl-2,3,4,5,6,7,7a,7b-octahydro-1aH-cyclopropa[h]azulen-4a-ol [Palustrol], was discovered to dock with the best binding affinity to all three proteins. In-silico pharmacological studies also confirmed its drug-likeness. This ligand should be further tested to understand its mode of action, ease of use and effectiveness against asthma symptoms.

Keywords

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