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1148 articles for “Derivate”
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Derivatization of Chiral Compounds with Chiral Reagents and Separation their Isomers by HPLC System
Abstract: Chiral compounds such as alanine amino acid and s-aminethylated L-cystiene derivatized with chiral reagents such as Marfey's reagents, 2,3,4,6-tetra-O-acetyl-b-D-glucopyranosylisothiocyanate (GITC) and 2,3,4,6-tetra-O-benzoyl-b-D-glucopyranosylisothiocyanate (BGIT), were achieved and separated by optimizing good methods using high performance liquid chromatography. Keywords: Derivatization, amino acid, chiral reagent, HPLCCite this Article Khlafulla Abdulrahim M, Maga Rajab A, Elmessmary Mohamad F. Derivatization of Chiral Compounds with Chiral Reagents and Separation their Isomers by HPLC System. Research & …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 6, Issue 2, 2016 · pp. 39–43 Read article
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Preparation and Characterization of Some of Formazan Derivatives
Abstract: Some formazan derivatives were prepared through reaction of benzaldehyde-phenylhydrazone with selected diazonium salts in alkaline medium in very good yields. The hydrazone were prepared by reaction of phenylhydrazine with benzaldehyde in slightly acidic medium. The structure of the formazan derivatives were fully established by physical and spectral methods. Keywords: Formazan, benzaldehyde phenylhydrazone, diazonium salts, spectroscopyCite this Article Hussniya A. AlDifar, Mohammad F. Ali, Abdulrahim M. Khlafulla. Preparation and Characterization of …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 7, Issue 1, 2017 · pp. 1–4 Read article
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Synthesis of Novel Sugar-Benzimidazole Derivatives
Abstract: Conversion of some unprotected and unmodified aldoses with o-phenylene diamine to aldo-imidazoles using iodine catalyst in acetic acid solution has been applied, according to a known method. Accordingly some novel derivatives have been synthesized. Characterization of the synthesized products has been performed by M.P., chromatography, IR and mass spectra. Keywords: Sugar-benzimidazole derivatives, IMs, carbohydrate labelingCite this Article Al-Difar Hussniya A, Basma Younis, Basma Saad Baaiu et al. Synthesis of Novel …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 7, Issue 2, 2017 · pp. 1–4 Read article
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3D-QSAR and Molecular Docking Studies of Triazol-Cycloalkanol Derivatives Used as Potent 3-Dehydroquinase II Inhibitors Against Mycobacterium tuberculosis
Abstract: Tuberculosis is a life threatening infectious disease caused by gram positive bacteria mycobacterium tuberculosis. Emergence of drug resistance, multi drug resistance and extensively drug resistance strain of mycobacterium make the situation more worst. It increases the mortality rate of tuberculosis patient, time duration and cost of treatment. Various inhibitors and drug molecules are designed to combat this fatal disease. Enzymes of shikimate pathway are responsible for production of essential amino …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 5, Issue 3, 2015 · pp. 18–28 Read article
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Exploitation of Ku Band and its Derived Products for Improvement of Quality of Life (QOL) of Rural Livelihood
Abstract: Normal 0 false false false EN-US X-NONE X-NONE This part of literature presents a proposed methodology which links the rural livelihood with space products derived applications for improvement of their Quality of Life (QOL) whilst overcoming existing challenges often faced by the workforce in solving grass root problems. Existing Information and communication technology practices an essence of this theme through various projects undertook by government of India and many are …
Published in Current Trends in Information Technology · Vol. 4, Issue 2, 2014 · pp. 1–3 Read article
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Synthesis, Characterization and Antibacterial Activity of Chalcone Derivatives
Abstract: Chalcone derivatives were produced by the Claisen-Schmidt condensation of aromatic aldehydes with methyl ketones. Chalone derivatives are valuable species as they belong to keto-ethylenic components. Chalcone is a one-of-a-kind template that is linked to a variety of biological processes. 2-hydroxy-2,5- dichloro acetophenon (1) were synthesized by Fries migration and condensed with aromatic aldehyde to produce the new chalcone derivatives (2a-e). The new 1-(2-hydroxy-3,5-dichlorophenyl)-aryl-prop2-ene-1-ones (2a-e) (chalcones) were characterized using FT-IR and …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 14, Issue 2, 2023 · pp. 42–46 Read article
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Synthesis, Characterization of Novel 5-(Dimethylamino) Naphthalene Sulfonamide Derivatives
Abstract: 5-(Dimethylamino) naphthalene-1-sulphonic acid was synthesized by methylation of 5-amino naphthalene-1-sulphonic acid. 5-(Dimethylamino) naphthalene-1-sulphonyl chloride were synthesized by the chlorination of 5-amino naphthalene-1-sulphonic acid. 5-(Dimethylamino) naphthalene-1-sulfonamide derivatives were synthesized by condensation of 5-(Dimethylamino) naphthalene-1-sulphonyl chloride and corresponding primary amines. There chemical structures were confirmed by I. R., 1HNMR and elemental analysis. Keywords: Synthesis, sulfonamides derivatives, 5-(Dimethylamino) naphthalene-1-sulphonic acid, 5-(Dimethylamino) naphthalene-1-sulphonyl chloride Cite this ArticleKhan Asif, Mishra Ritesh, Malvia Hitesh, et al. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 2, 2015 · pp. 1–5 Read article
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Synthesis, Characterization and Pharmacological Evaluation of Amide Derivates of Prednisolone
Abstract: prodrugs. These novel prodrugs were also characterized with the help of usual analytical and spectral techniques (IR spectroscopy and NMR spectroscopy). These newly synthesized ester derivates of prodrugs were screened for their spectral techniques. All the above compounds showed significant anti-inflammatory effect at 50 mg/kg p.o. and the experimental data are statistically significant at p< 0.05 level. The pharmacological activities exhibited by synthesized novel compounds have confirmed that they may …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 1, 2016 · pp. 1–13 Read article
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Design, Synthesis and Pharmacological Evaluation of Pyrazoline Substituted Benzimidazole Derivatives as Antibacterial and Antifungal Agents
Abstract: Background: Benzimidazoles are important heterocyclic compounds possessing a variety of biological activities such as anticancer, antioxidant, antiinflammatory, analgesic, anti-viral, anti-bacterial, anti-fungal and hypoglycemic activities. Pyrazolines are used as antitumor, immunosuppressive, antibacterial and anti tubercular agents. Aim : The present research focused on incorporating pyrazoline nucleus into benzimidazole nucleus to form a potent antibacterial and antifungal agent. Method: The in silico design of novel pyrazoline substituted benzimidazole derivatives was done using …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 3, 2020 · pp. 29–41 Read article
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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Pharmacokinetics and Pharmacodynamics Studies of Chia Seed Derived Compounds; A Review
Abstract: Chia seeds (Salvia hispanica L.) have been historically valued by ancient civilizations and are increasingly being recognized for their powerful nutritional and therapeutic properties. Rich in omega-3 fatty acids, polyphenols, fiber, and essential minerals, chia seeds are gaining attention for their potential health benefits. This review examines the pharmacokinetics and pharmacodynamics of chia seed-derived compounds, with emphasis on their absorption, distribution, metabolism, and elimination processes, as well as their biological …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 1, 2025 · pp. 9–15 Read article
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Therapeutic Potential of Plant-Derived Phytochemicals in Targeting Receptor Pathways Related to Non-Enzymatic Glycation: A Meta-Analysis
Abstract: Background: Non-enzymatic glycation, where reducing sugars react with proteins, lipids, and nucleic acids, contributes to various pathological conditions, such as diabetic complications and cardiovascular diseases. This process is facilitated by the receptor for advanced glycation end-products (RAGE), which is pivotal in driving inflammation and causing tissue damage. Objective: This meta-analysis evaluates the effects of plant-derived phytochemicals on RAGE expression and associated signaling pathways, assessing their therapeutic potential in glycation-related diseases. …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 60–73 Read article
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Preparation, Spectral Characterization and Bio-Evaluation of Five and Seven Membered Ring Derivatives
Abstract: Many cyclic compounds are made of heterogeneous atoms that are good electron donors to be the basic nucleus in the basic structure of chemical drugs, so most drugs and vitamins take cyclic compounds as a basic material for the manufacture of drugs, and without a doubt these drugs are distinguished by their high ability to make many biologically active derivatives in the fields of biochemistry and clinical medicine. Universal studies …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 2, 2025 · pp. 96–109 Read article
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High-Performance Biodegradable Films from Bamboo Derived Cellulose Nanofibers and Silk Fibroin: Engineering Sustainable Polymer Composites
Abstract: This research presents the advancement of biodegradable composite films from cellulose nanofibers (CNFs) extracted from bamboo and silk fibroin (SF) derived from Bombyx mori cocoons. CNF/SF composites were fabricated in three different compositions—CS10, CS30, and CS50—via aqueous blending and solution casting, followed by ethanol-induced β-sheet stabilization. Mechanical testing confirmed a considerable enhancement in tensile strength from 72 MPa (CS10) to 112 MPa (CS50), while Young’s modulus improved from 2.4 GPa …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 256–265 Read article
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Exploring Type-II Diabetes Potential of Phyto-Derived Carbon Dots
Abstract: The integration of phytoconstituents with carbon dots (C-dots) presents a novel and sustainable approach to the development of nanotherapeutics for type 2 diabetes mellitus (T2DM). C-dots, zero-dimensional carbon-based nanomaterials, exhibit unique physicochemical properties including high fluorescence, tunable surface chemistry, biocompatibility, and low toxicity. Their ability to enhance the solubility, bioavailability, and targeted delivery of poorly soluble phytochemicals renders them highly suitable for biomedical applications. This study explores the synthesis of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 08–25 Read article
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Fungal-derived Nutraceuticals & Bioactive Compounds with Physiotherapeutic and Health- promoting Properties: A Comprehensive Review
Abstract: Fungal-derived nutraceuticals represent a rapidly expanding field in biomedical research, offering a rich source of bioactive compounds with diverse therapeutic applications. This comprehensive review examines the physiotherapeutic and health-promoting properties of fungal metabolites, including polysaccharides, terpenes, proteins, peptides, alkaloids, fatty acids, vitamins, and minerals. Fungi produce over 9,000 bioactive compounds from approximately 22,500 microbial metabolites, with less than 5% of the fungal kingdom explored [1] . The major bioactive constituents …
Published in International Journal of Fungi · Vol. 2, Issue 2, 2025 Read article
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Molecular Docking, QSAR Modeling, and ADMET Evaluation of Novel Pyrazolo-Pyrimidine Derivatives as Potential CDK-2 Inhibitors for Cancer Therapy
Abstract: Cyclin-dependent kinase-2 (CDK-2) is an essential regulator in cell cycle progression and is an important therapeutic target in cancer drug development. In the present study, an integrated computational approach involving molecular docking studies, QSAR modeling, ADMET prediction, and artificial intelligence-based analysis was used to identify pyrazolo-pyrimidine derivatives as potential CDK-2 inhibitors. Based on the molecular docking results, it was found that selected compounds exhibited high binding affinity towards the ATP …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Polymeric Emulsion Composite System Enriched with Eggshell-Derived Biominerals for Dermal Delivery
Abstract: This study describes the development and characterization of a sustainable polymeric water-in-oil (W/O) emulsion composite designed for dermal delivery and skin repair applications. The formulation was prepared using a lipid-rich biopolymeric matrix containing glyceryl stearate, beeswax, and plant-derived ingredients, which acted as the continuous phase for stabilizing and dispersing inorganic mineral fillers. Eggshell waste was utilized as a natural calcium source and combined with magnesium and zinc oxide to create …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Novel 1,3,4-Thiadiazole Derivatives: Design, Synthesis, Characterization and Anticancer Evaluation – A Review
Abstract: Cancer remains one of the leading causes of mortality worldwide despite significant advances in diagnosis and treatment. The clinical usefulness of many anticancer drugs is often restricted by toxicity, poor selectivity, and the emergence of drug resistance. These limitations have encouraged the search for novel heterocyclic compounds with improved therapeutic efficacy and safety. Among these, the 1,3,4-thiadiazole scaffold has gained considerable attention because of its favorable physicochemical characteristics, metabolic stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 42–49 Read article
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A New Protocol for The Synthesis of 5-(azidomethyl)-4-phenyl-1H- 1,2,3-triazole From Baylis-Hillman Adducts Derived from Nitro Olefins.
Abstract: The Baylis-Hillman adducts derived from nitroolefins have been convenientlytransformed into 5-(azidomethyl)-4-phenyl-1h-1,2,3-triazole via simple reaction condition. These compounds have been demonstrated for the synthesis of azidomethyl is highly biological reactive compounds. This novel bromo derivative of the BH adduct was simply treated with mole percentage of sodium azide in reactive condition. As a result, these novel azidomethylcompounds were extremely encouraging and provided fresh chances for building libraries of several new molecules. …
Published in Emerging Trends in Chemical Engineering · Vol. 9, Issue 2, 2022 · pp. 42–46 Read article