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Research & Reviews: A Journal of Drug Design & Discovery Review Article

Pharmacokinetics and Pharmacodynamics Studies of Chia Seed Derived Compounds; A Review

  1. Mohd.Wasiullah Dept.of Pharmacy, Prasad Institute of Technology, Jaunpur
  2. Piyush Yadav Department of Pharmaceutical Chemistry, Prasad Institute of Technology, Jaunpur
  3. Deepak Kumar Patel Dept.of Pharmacy, Prasad Institute of Technology, Jaunpur

Abstract

Chia seeds (Salvia hispanica L.) have been historically valued by ancient civilizations and are increasingly being recognized for their powerful nutritional and therapeutic properties. Rich in omega-3 fatty acids, polyphenols, fiber, and essential minerals, chia seeds are gaining attention for their potential health benefits. This review examines the pharmacokinetics and pharmacodynamics of chia seed-derived compounds, with emphasis on their absorption, distribution, metabolism, and elimination processes, as well as their biological effects. Chia-derived omega-3 fatty acids, polyphenols, and fiber promote anti-inflammatory, antioxidant, cardiovascular, neuroprotective, and gastrointestinal benefits. Despite the promising results of clinical research, there are some issues such as biological utilization and low restrictions on production. As functional foods, chia seeds offer significant potential for improving health and preventing chronic diseases, although further research is needed to fully optimize their therapeutic applications.

Keywords

References (12)

  1. Urbizo-Reyes U, San Martin-González MF, Garcia-Bravo J, López Malo Vigil A, Liceaga AM. Physicochemical characteristics of chia seed (Salvia hispanica) protein hydrolysates produced using ultrasonication followed by microwave-assisted hydrolysis. Food Hydrocolloids. 2019;97:105187. doi:10.1016/j.foodhyd.2019.105187
  2. Coates, Wayne; Ayerza, Ricardo (1998). “Commercialproductionofchia in Northwestern Argentina”. Journal of the American Oil Chemists’Society. 75 (10): 1417–1420.
  3. Sinclair AJ, Begg D, Mathai M, Weisinger RS. Omega 3 fatty acids and the brain: review of studies in depression. Asia Pac J Clin Nutr. 2007;16 Suppl 1:391-7.
  4. Grancieri M, Martino HSD, Gonzalez de Mejia E. Chia Seed ( Salvia hispanica L.) as a Source of Proteins and Bioactive Peptides with Health Benefits: A Review. Comprehensive Reviews in Food Science and Food Safety. 2019;18(2):480-499. doi:10.1111/1541-4337.12423
  5. Fateh HL, Ahmed DH, Najafabadi MS, Moludi J. The impact of chia seeds on diabetes, blood pressure, lipid profile, and obesity indicators: Systematic review and meta-regression analysis of 14 randomized controlled trials. Prostaglandins & Other Lipid Mediators. 2024;175:106907. doi:10.1016/j.prostaglandins.2024.106907
  6. Ullah R, Nadeem M, Khalique A, Imran M, Mehmood S, Javid A, et al. Nutritional and therapeutic perspectives of Chia (Salvia hispanica L.): a review. Journal of Food Science and Technology. 2015;53(4):1750-1758. doi:10.1007/s13197-015-1967-0
  7. Nieman DC, Gillitt N, Jin F, Henson DA, Kennerly K, Shanely RA, et al. Chia Seed Supplementation and Disease Risk Factors in Overweight Women: A Metabolomics Investigation. The Journal of Alternative and Complementary Medicine. 2012;18(7):700-708. doi:10.1089/acm.2011.0443
  8. Luz JMRD, Nunes MD, Paes SA, Torres DP, Silva MDCSD, Kasuya MCM. Lignocellulolytic enzyme production of Pleurotus ostreatus growth in agroindustrial wastes. Brazilian Journal of Microbiology. 2012;43(4):1508-1515. doi:10.1590/s1517-83822012000400035
  9. Reyes-Caudillo E, Tecante A, Valdivia-López MA. Dietary fibre content and antioxidant activity of phenolic compounds present in Mexican chia (Salvia hispanica L.) seeds. Food Chemistry. 2008;107(2):656-663. doi:10.1016/j.foodchem.2007.08.062
  10. Das A. Advances in Chia Seed Research. Advances in Biotechnology & Microbiology. 2017;5(3). doi:10.19080/aibm.2017.05.555662
  11. Mohd Ali N, Yeap SK, Ho WY, Beh BK, Tan SW, Tan SG. The Promising Future of Chia,Salvia hispanicaL. Journal of Biomedicine and Biotechnology. 2012;2012:1-9. doi:10.1155/2012/171956
  12. Ullah R, Nadeem M, Khalique A, Imran M, Mehmood S, Javid A, et al. Nutritional and therapeutic perspectives of Chia (Salvia hispanica L.): a review. Journal of Food Science and Technology. 2015;53(4):1750-1758. doi:10.1007/s13197-015-1967-0
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