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182 articles for “Formulation Optimization”
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A Review of the Role of Fiber Supplements in Digestive Health and Weight Management
Abstract: The essential component of a nutritious diet is dietary fiber which enables body weight regulation and maintains digestive system health. Several supplements derived from fiber have gained popularity during recent years since they help improve gut health while controlling weight and preventing metabolic diseases. The two major groups which make up fiber are soluble and insoluble fibers that impact the body differently. The soluble fiber components psyllium inulin and beta-glucans …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 24–35 Read article
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Experimental Analysis of Aramid Fiber Reinforced with Tungsten Carbide
Abstract: This study investigates the mechanical performance of aramid fiber-reinforced epoxy composites enhanced with varying weight percentages of tungsten carbide (WC) powder as a secondary reinforcement. The composites were fabricated using both the hand lay-up and vacuum bagging techniques to ensure uniform dispersion of materials and quality surface finish. Tungsten carbide particles with an average size of 4 microns were incorporated into the aramid fiber matrix at incremental concentrations of 0%, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 146–157 Read article
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A Mathematical Perspective on Recent Cloud-Computing Trends for Scalable and Secure Social-Media Platforms
Abstract: Cloud computing underpins modern social-media platforms by providing elastic compute, storage, and data-processing pipelines capable of absorbing highly bursty workloads. This paper surveys recent cloud-native trends—serverless and event-driven design, container orchestration, edge/CDN offload, streaming analytics, and privacy-enhancing security controls—and formalizes their impact through a compact mathematical model. We express workload volatility using arrival-rate functions, use queueing-based capacity sizing to derive auto-scaling rules, and formulate an optimization objective that balances cost …
Published in Recent Trends in Mathematics · Vol. 3, Issue 2, 2026 · pp. 35–40 Read article
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Enhanced Bioavailability of Nutrients in Pelleted Feeds: Implications for Performance, Health, and Meat Quality of the Broiler Chicken
Abstract: The optimization of nutrient bioavailability in pelleted feeds is crucial for enhancing the performance, health, and meat quality of broiler chickens. This review explores the complex mechanisms by which pelleting improves nutrient availability, including physical changes in feed structure, thermal and chemical effects, and the reduction of anti-nutritional factors. It also highlights the significance of improved gut health and digestion, which contributes to enhanced nutrient absorption and utilization. The paper …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 1, 2025 · pp. 12–32 Read article
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Design and Manufacturing of Suspension and Steering System of a F3 Vehicle
Abstract: The suspension and steering systems are critical subsystems of any formula-style racing vehicle, directly influencing its stability, handling, and driver safety. This paper focuses on the design, analysis, and manufacturing of suspension and steering systems for a Formula Student F3 vehicle. The primary objective is to develop a lightweight, reliable, and efficient design that complies with Formula Student competition rulebooks while ensuring optimum ride quality and performance. Using advanced computer-aided …
Published in Trends in Mechanical Engineering & Technology · Vol. 15, Issue 3, 2025 · pp. 1–12 Read article
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Development and Fabrication of Biohydrogel for Targeted Delivery of Delafloxacin for Bacterial Skin Infections
Abstract: The escalating challenge of bacterial resistance necessitates innovative drug delivery systems to enhance the efficacy of antibiotics. This study focuses on the development and optimization of a biohydrogel formulation for the targeted delivery of Delafloxacin, aiming to improve its therapeutic outcomes against resistant bacterial strains. Utilizing a 3² factorial design, biohydrogel formulations incorporating Poly(N-isopropylacrylamide) (PNIPAM) and Genipin were synthesized. The optimization process was guided by Design Expert software, focusing on …
Published in Research & Reviews: A Journal of Drug Design & Discovery Read article
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Optimizing Mechanical and Durability Properties of Eco-Friendly Composite Materials Using Recycled Fillers and ML Techniques
Abstract: The increasing demand for sustainable construction materials has intensified the exploration of recycled fillers as partial or full replacements for natural aggregates in composite materials. This study investigates the mechanical and durability performance of polymer matrix composites incorporating processed recycled fillers derived from construction and demolition (C&D) waste. Three distinct processing methods were employed to prepare the recycled fillers: untreated (URF), single processed (SPRF), and double processed (DPRF), with replacement …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 269–309 Read article
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Egg Quality in Laying Hens: Optimizing Genetic, Nutritional, Environmental and Management Factors for Sustainable Layer Farming
Abstract: This review paper provides a comprehensive analysis of the critical factors affecting egg quality in laying hens, focusing on the integration of genetic, environmental, nutritional, and management practices. Egg quality, including shell strength, albumen consistency, and yolk pigmentation, is a key determinant of both production efficiency and marketability. Genetic factors, such as selection for desirable traits, like shell integrity and yolk color, have a significant impact on the overall quality …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 2, 2025 · pp. 1–15 Read article
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Detecting the Failure Stages in Asphalt Concrete Through the Fatigue Life
Abstract: The signs of failure initiation in asphalt concrete through its service life may appear as cracking, rutting, or other types of distress after practicing dynamic stresses from vehicular loading. This work is concerned with detecting the failure initiation in asphalt concrete in the laboratory, and the role of binder content and constant strain level through a comprehensive testing program. Asphalt concrete mixtures were formulated with the optimal binder content, as …
Published in Trends in Transport Engineering and Applications · Vol. 11, Issue 1, 2024 · pp. 21–27 Read article
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Development of Environmentally Sustainable Epoxy Composites with Sunflower Seed Husk Fillers and Study on Thermal and Moisture Properties
Abstract: This study examines the development and characterization of epoxy composites reinforced with sunflower seed husk (SSH) fillers fabricated using the compression molding technique. SSH fillers were categorized into two distinct particle size distributions, namely, 4–53 µm and 79–463 µm, and were incorporated into the epoxy matrix at varying volume fractions ranging from 5% to 20%. The water absorption behavior of the composites was assessed according to ASTM standards, and thermogravimetric …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 28–37 Read article
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Spectral Intuitionistic Fuzzy Hypergraph Operators and Dominance Kernels for Resilient Discrete Network Design
Abstract: A new discrete-mathematical framework is developed for resilient network design on intuitionistic fuzzy hypergraphs, where uncertainty is explicitly represented through membership, non-membership, and hesitation degrees associated with both vertices and hyperedges. These three components are systematically integrated into an effective incidence operator that captures the underlying uncertain relationships within complex hypergraph structures. Based on this operator, both un-normalised and normalized Laplacian matrices are formulated to characterize the spectral properties and …
Published in Recent Trends in Mathematics · Vol. 3, Issue 2, 2026 · pp. 41–48 Read article
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Effect of Skin Barrier Damage on Absorption and Action of Cosmeceuticals
Abstract: The skin acts as a primary defensive barrier protecting the human body against environmental aggressors, microbial invasion, and chemical exposure. The integrity of the skin barrier, particularly the stratum corneum, plays a crucial role in regulating the permeation of substances applied topically. Cosmeceuticals, a hybrid category between cosmetics and pharmaceuticals, are designed to deliver biologically active ingredients into the skin to exert therapeutic or beneficial effects. However, the condition of …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 2, 2026 · pp. 1–19 Read article
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Formulation and Evaluation of a Polyherbal Lip Scrub Containing Beetroot, Licorice, and Aloe Vera
Abstract: The current research is aimed at developing and assessing a polyherbal lip scrub which contains beetroot extract, licorice extract and aloe vera gel to enhance better exfoliation, nutritional and depigmentation. The fusion method was applied to the herbal extract formulations by varying systematically the concentration of the herbal extracts to develop the 4 formulations (F1-F4) each of 15 g. These prepared formulations were tested on their important physicochemical and functional …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 Read article
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Controlled Drug Delivery of Furosemides Using Floating Tablet System
Abstract: The development of gastroretentive drug delivery systems (GRDDS) has gained interest, particularly for drugs like furosemide with narrow absorption windows in the upper gastrointestinal (GI) tract. Furosemide, a commonly used diuretic, faces challenges due to limited bioavailability and rapid elimination, requiring frequent dosing and affecting patient compliance. This review highlights the formulation and evaluation of floating furosemide tablets as an effective strategy to enhance therapeutic efficacy. Floating tablets allow prolonged …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 23–31 Read article
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Artificial Intelligence–Assisted Reduced-Order Modeling and Stability Control in Granular Couette Flow
Abstract: This study develops a reduced-order and stability-aware modeling framework for dense granular Couette flow by integrating continuum mechanics, bifurcation analysis, and data-driven stability estimation. Starting from coupled governing equations for momentum, granular temperature, and microstructural evolution, the system is nondimensionalized and reduced using a Galerkin projection consistent with shear-driven boundary conditions. This yields a low-dimensional nonlinear dynamical system that preserves the essential coupling between velocity, fluctuation energy, and structural relaxation. …
Published in Emerging Trends in Chemical Engineering · Vol. 13, Issue 3, 2026 Read article
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Nano-Chemical Revolution in Vaccinology: A Study
Abstract: The development of traditional vaccines, reliant on attenuated pathogens or purified proteins, has historically been limited by slow development timelines, poor stability, and low immunogenicity requiring potent, often non-specific, adjuvants. This synthesis argues that the convergence of nano-material science and meticulous chemical engineering represents the next major paradigm shift in preventative medicine. Nano-materials, particularly Lipid Nanoparticles (LNPs) and various polymeric or inorganic scaffolds, have transitioned from theoretical constructs to essential …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 Read article
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Fabrication and Characterization of Diacerein Loaded Nanosponge for Topical Delivery
Abstract: Diacerein, an anti-inflammatory drug, which comes under BCS class II, commonly used in treatment of osteoarthritis has limited by its poor solubility and bioavailability when administered topically. This study aimed to develop and evaluate diacerein-loaded nanosponges gel using varying concentrations of ethyl cellulose and polyvinyl alcohol (PVA) to enhance its delivery. Nanosponges were prepared using an emulsion solvent evaporation technique, with different ratios of ethyl cellulose (0.05-0.250%) and PVA (0.2-0.3%). …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 26–46 Read article
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Polymeric Materials in Drug Delivery: Applications in Topical Formulations
Abstract: Polymeric materials play a crucial role in modern drug delivery systems, particularly in topical formulations. These materials enhance drug stability, control release rates, and improve bioavailability, making them essential components in pharmaceutical advancements. Polymers such as chitosan, hydrogels, and emulsifying agents are widely utilized in immediate-release topical formulations, where they contribute to improving therapeutic efficacy by ensuring uniform drug distribution, increased solubility, and enhanced skin penetration. The integration of polymer-based …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 34–41 Read article
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Biomedical Approach to Developing and Characterizing Chitosan Nanoparticles Encapsulating Urapidil for Hypertension Management
Abstract: The aim of this study was to create Chitosan Nanoparticles loaded with Urapidil to achieve controlled drug release, enhance solubility, and reduce dosing frequency to improve patient adherence to therapy for hypertension. Urapidil was formulated into nanoparticles via the ionic-gelation method using Chitosan as a polymer, Sodium tripolyphosphate as a cross-linking agent, and filled into hard gelatin capsules after lyophilization. Pre-formulation studies, including melting point analysis and determination of the …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 43–51 Read article
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Authentication of a Rapid RP-HPLC technique for Quantification of Remogliflozin and Metformin in Medicinal Formulations
Abstract: A new, precise, and stability-assessing advanced liquid chromatography (HPLC) technique for simultaneous quantification of Remogliflozin and Metformin in fixed dose pharmaceutical formulations was designed and verified. Optimization of the technique was carried out on flowing phase composed of ethanenitrile and buffer, under isocratic conditions, the resolution of peak being sharp with retention times of 3.24 min and 4.89 min for Remogliflozin and Metformin, respectively. Technology suitability was confirmed by the …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 70–77 Read article