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394 articles for “therapeutic drug”
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Comparative Efficacy and Safety of Safinamide and Rasagiline in the Treatment of Parkinson’s Disease: A Meta-Analysis and Systematic Review
Abstract: Background: Recent studies have suggested Rasagiline and Safinamide monotherapy as potential management options for Parkinson’s disease. Parkinson’s disease, a neurological disorder characterized by tremors and movement difficulties, necessitates treatments aimed at managing clinical symptoms. Levodopa remains the primary effective treatment for Parkinson’s disease symptoms; however, its long-term use often leads to motor complications in many patients. Additional therapeutic drugs, such as dopamine agonists and monoamine oxidase B inhibitors, including Safinamide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 74–91 Read article
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The Role of Pyruvate Dehydrogenase in Non-Alcoholic Fatty Liver Disease: Therapeutic Insights and Future Directions
Abstract: Non-alcoholic fatty liver disorders (NAFLD) are defined by the accumulation of excess fat in the liver that has no other cause, such as drinking alcohol. Pyruvate dehydrogenase has been established as an alternative treatment for this disorder. NAFLD pathogenesis is complex and includes oxidative stress inflammatory processes and mitochondrial dysfunction. Impaired liver fatty acid oxidation and glucose oxidation are significant individuals in developing NAFLD, and strategies to reverse these defects …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 44–51 Read article
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Disease X: Unveiling the Unknown Pathogen and Enhancing Global Preparedness
Abstract: “The concept of “Disease X” was introduced to drive the creation and refinement of versatile technologies such as vaccines, therapeutic drugs, and diagnostic tests, which could be swiftly adapted and utilized in response to future infectious disease outbreaks with epidemic or pandemic potential. The aim was to establish a proactive approach to emerging health threats by developing platform technologies capable of addressing a broad spectrum of potential pathogens. The COVID-19 …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 3, 2024 · pp. 15–20 Read article
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Bioanalytical Method Development and Validation for the Estimation of Levothyroxine in Human K₃EDTA Plasma by Using UPLC-MS/MS
Abstract: A rapid, sensitive, and highly selective UPLC-MS/MS method was developed and validated for the quantitative estimation of Levothyroxine in human plasma using Levothyroxine-D₃ as the internal standard (IS). Chromatographic separation was achieved on a Gemini NX-C18 column (50 × 3.0 mm, 3 µm) with a mobile phase consisting of acetonitrile and water (70:30, v/v) containing 0.015% formic acid at a flow rate of 0.5 mL/min. The total run time was …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 32–46 Read article
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Neuropharmacological Mechanisms of Psychedelics: Advancing Treatment Strategies for Mental Health Disorder
Abstract: The resurgence of interest in the therapeutic potential of psychedelic drugs has caused a major upheaval in the field of psychiatry in recent years. This review's main goal is to thoroughly examine the possible benefits of psychedelic drugs in the field of psychiatry, with a focus on how they might be used as psychotherapy aids. Given their widespread use in therapeutic settings, clinical trials involving MDMA, psilocybin, ketamine, and LSD …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 67–79 Read article
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The use of Genetics and Proteomics in the Finding of Therapeutic Targets
Abstract: Gene medicine is overcoming long-standing health issues that have confounded humanity. To fully comprehend and apply gene medicine, it is vital to grasp how it works at the molecular level. Currently, various technologies may be utilized to find pharmacological targets; the two most prominent are genomic and proteomic methods. In this paper, we go over how to use genomic and proteomic approaches to find pharmacological targets in depth. These materials …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 1, 2022 · pp. 9–12 Read article
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Revolutionizing Gastro-retentive Drug Delivery: Exploring Innovative Formulation Strategies and Mechanisms in Floating in Situ Gel Raft Forming System
Abstract: An in-depth exploration of the transformative shift underway in gastro-retentive drug delivery, spotlighting the utilization of Floating Drug Delivery Systems (FDDS) and specifically honing in on the innovative formulation strategies and mechanisms inherent in Floating In Situ Gel Raft Forming Systems. FDDS present a promising avenue for revolutionizing drug delivery efficacy by capitalizing on buoyancy to float atop the gastric fluid surface, thereby extending gastric residence time and improving drug …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 9–21 Read article
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Bioenhancer to Boost Herbal Drug Efficacy
Abstract: Bioenhancers are natural substances that significantly improve the absorption, bioavailability, and therapeutic efficacy of drugs when co-administered, without showing notable pharmacological activity of their own. In herbal medicine, the concept of bioenhancement has received growing attention as many phytoconstituents exhibit low oral bioavailability due to poor solubility, limited permeability, and extensive first-pass metabolism. The traditional Ayurvedic system first introduced this concept through the discovery of Piperine, the active alkaloid from …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 · pp. 01–13 Read article
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Flaxseed-Based Drug Delivery Systems: Advancing Colon Cancer Treatment
Abstract: Flaxseed (Linum usitatissimum) has long been appreciated for its rich nutritional profile, including essential fatty acids (such as α-linolenic acid), plant fibers, and lignans. Recent research has focused on its potential as a novel drug delivery system (DDS) for the treatment of colon cancer. This review explores the bioactive constituents of flaxseed, their pharmacological activities, and innovative approaches to the use of flaxseed extracts in drug delivery for the treatment …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 54–59 Read article
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Pf Phosphatidylserine decarboxylase: Molecular modeling and inhibithors prediction
Abstract: Plasmodium falciparum (P.f) is a protozoan parasite responsible for the most severe and deadly form of malaria. The resistance of Pf to last resort antimalarial drugs has been reported, there is an urgent need to identify new therapeutic candidates for drug development. Advancements in bioinformatics technologies provide potential cost and time-effective solutions for predicting therapeutic candidates. Phosphatidylserine decarboxylase (PSD) is a member of the lyase family (more specifically, the carboxy-lyases), …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 2, 2023 · pp. 60–78 Read article
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Chemotherapy: Side Effect and Management
Abstract: Cytotoxic drugs are therapeutic agents intended for but not constrained to, the treatment of cancer. These drugs are kenned to be highly toxic to cells, mainly through their action on cell reproduction. Cytotoxic drugs are increasingly being utilized in a variety of health care settings, laboratories and veterinary clinics for the treatment of cancer and other medical conditions such as rheumatoid arthritis, multiple sclerosis are autoimmune disorders. Cytotoxic drugs are …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 3, 2016 · pp. 30–40 Read article
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Microsphere-Based Drug Delivery: A Critical Review of Innovations and Applications
Abstract: Microspheres have emerged as a revolutionary approach in pharmaceutical sciences, offering controlled and targeted drug delivery with improved bioavailability, stability, and patient compliance. These spherical carriers, ranging from nanometers to micrometers in size, can encapsulate both hydrophilic and hydrophobic drugs, enabling sustained and site-specific release. The development of microspheres has been significantly driven by the need to enhance drug efficacy while minimizing systemic side effects. This review provides a comprehensive …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 52–59 Read article
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Polymer Chemistry and Composite Materials in Biomedical Applications
Abstract: The integration of polymer chemistry and composite materials has revolutionized biomedical applications. Recent advancements in polymer synthesis, functionalization, and nanotechnology have further expanded their applications, leading to significant improvements in biocompatibility, biodegradability, and mechanical performance. These polymeric carriers protect bioactive compounds from enzymatic degradation, enable controlled drug release, and improve therapeutic efficacy. The integration of polymer chemistry with nanotechnology has enabled the development of highly efficient, targeted therapeutic systems that …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 413–419 Read article
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Nanoformulation Strategies: Emerging Innovations in Drug Delivery Systems
Abstract: Nanotechnology is significantly advancing the pharmaceutical industry by introducing nanosystems that improve drug delivery, therapeutic efficacy, and patient outcomes. Various nanosystems-such as liposomes, dendrimers, polymeric nanoparticles, solid lipid nanoparticles, carbon nanotubes, and metallic nanoparticles-offer benefits like enhanced bioavailability, targeted delivery, improved stability, and reduced side effects. Innovative formulation strategies, including surface functionalization, particle size optimization, and use of biodegradable carriers, support controlled and sustained drug release. Additionally, production in non-aqueous …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 54–67 Read article
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Heterocyclic Substituted Flavones: Bridging Natural Products and Medicinal Chemistry
Abstract: Heterocyclic substituted flavones represent a unique and promising class of flavonoid derivatives, gaining significant attention in recent years due to their diverse and enhanced biological activities. These compounds are characterized by the incorporation of heterocyclic moieties such as quinoline, pyridine, thiazole, imidazole, oxazole, and pyrazole into the flavone structure, which significantly alters and often enhances their bioactive properties. This structural modification has made heterocyclic flavones particularly appealing as candidates for …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 23–30 Read article
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Recycling of Expired Chemical Drugs and Controlling of Organic Chemical Compounds
Abstract: Expired chemicals in chemical medicines represent a big problem in chemical medicines and we must find ways to treat expired medicines. It proposes a new technology for reuse instead of burying it with ordinary waste or instead of burning it in the ovens of the soil company, The side effects of an expired medicine (its chemical substances are out of date and ineffective in healing) are any unwanted effects of …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 2, 2024 · pp. 12–20 Read article
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Hydroxylated Chalcone Derivatives as Future Aldose Reductase Inhibitors: Discovery through Docking Technique
Abstract: The research endeavors molecular docking assisted exploration of ALR inhibitory perspectives of some B-ring substituted hydroxyl group (A-ring) containing chalcone compounds against human aldose reductase in complex with NADP+ and the inhibitor IDD594 (PDB ID: 1US0) by utilizing the iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. The present investigation immensely focused on the human aldose reductase inhibitory perspectives of some hydroxylated chalcone compounds. The inhibition of the enzyme by …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 1, 2019 · pp. 8–12 Read article
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Pharmacodynamics and Drug–Receptor Interactions: Integrating PK/PD Modeling with Modern Drug Development
Abstract: Understanding drug action requires an integrated perspective of pharmacodynamics and pharmacokinetics, which together determine therapeutic efficacy and safety. This review provides a comprehensive overview of the mechanisms underlying drug action, with particular emphasis on drug–receptor interactions and their role in modulating physiological responses. Drugs exert their effects primarily through interactions with specific biological targets, including receptors, enzymes, ion channels, and transporters, resulting in a spectrum of desired and adverse outcomes. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 · pp. 33–47 Read article
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In Silico Assessment of Demethoxycurcumin: Molecular Docking and Computational Insights into its various therapeutic Potential
Abstract: Natural compounds are increasingly explored for their therapeutic potential in medical research. Here, we focused on demethoxycurcumin (DMC), a polyphenolic bioactive compound extracted from Curcuma longa, commonly found in turmeric. DMC, with a chemical formula of C20H18O5 and a molecular weight of 340 g/mol, possesses two aromatic ring systems, each featuring a β-diketone moiety connected by a seven-carbon chain. This unique structure allows DMC to engage in tautomerism, which is …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 9–15 Read article
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Revolutionizing Drug Delivery: Recent Advances in Pharmaceutical Dosage Forms
Abstract: Recent advances in pharmaceutical dosage forms revolutionize drug delivery, prioritizing targeted therapy and patient well-being. Enhanced drug carriers address complex medical challenges, from high-grade gliomas to ocular drug delivery, maximizing therapeutic efficacy while minimizing adverse effects. Traditional dosage forms like tablets and capsules undergo meticulous formulation and manufacturing processes, integrating Quality by Design principles for consistent product quality. Liquid formulations encounter stability challenges, necessitating rigorous stability testing and pH monitoring. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 1, 2024 · pp. 77–89 Read article