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278 articles for “Spectroscopic methods.”
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Chemical Constituents and Tyrosinase Inhibitory Activity of Ethyl Acetate Extract of the Leaves of Morus alba L. from Vietnam
Abstract: AbstractFour compounds (DB1–4) were isolated from the Mulberry leaves (Morus alba L.) collected in Thai Nguyen province by chromatographic methods. These compounds were identified as: Kaempferol-3-O-β-D-glucopyranoside (DB1), quercetin 3-O-α-L-rhamnopyranoside (DB2), isofraxidin-7-O-β -D-glucopyranoside (DB3), and (±) -3, 5, 6, 7, 8, 4’-hexahydroxyflavane (DB4). Their structures were elucidated by spectroscopic methods, including mass spectrometry (MS) and nuclear magnetic resonance (NMR). Compound DB4 was isolated from Mulberry leaves for the first time. Compound …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 1, 2018 · pp. 21–26 Read article
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Method, Development and Validation of Emtricitabine and Tenofovir by Using RP-HPLC in Pharmaceutical Dosage Forms
Abstract: A new method was established for simultaneous estimation of Emtricitabine and Tenofovir by RP-HPLC method. The chromatographic conditions were successfully developed for these parathions of Emtricitabine and Tenofovir by using Xterra C185 µm (4.6*250 mm) column, flowrate was1ml/min, mobile phase ratio was phosphate buffer (0.05 M) pH4.6: CAN (55:45% v/v) (pH was adjusted with ortho-phosphoric acid), detection wavelength was 255nm. Theretentiontimewas2.399and3.907 min. for Emtricitabine and Tenofovir, respectively. The percentage purity …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 1, 2018 · pp. 37–41 Read article
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Chemical Constituents and Tyrosinase Inhibitory Activity of Aqueous Fraction of the Leaves of Morus alba L. from Vietnam
Abstract: The mulberry has been widely cultivated to feed silkworms. The leaves of mulberry have been used in traditional medicine as an analgesic, antitussive, cathartic, diuretic. In this study we have isolated three compounds (LC1-3) by chromatographic methods from the Mulberry leaves (Morus alba L.) collected in Thai Nguyen province, Vietnam. These compounds were identified as: Kaempferol-3,7-di-O-α-L-rhamnopyranoside (LC1), 7,4’-dihydroxy-5,3’-dimethoxyflavone (LC2), (S)-5,5’,7-trihydroxy-2’,4’-dimethoxy-6-methylflavanone (LC3). Their structures were elucidated by spectroscopic methods, including MS …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 3, 2017 · pp. 12–17 Read article
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Synthesis, spectroscopic, crystal structure, Hirshfeld surface, computational, and biological investigations on Isophorone derivatives: 3-(3,4-dimethoxystyryl)-5,5-dimethylcyclohex-2-en-1-one
Abstract: FT-IR, 1H NMR, and 13C NMR spectroscopy were among the spectroscopic methods used to synthesize and analyze 3-(3,4-dimethoxystyryl)-5,5-dimethylcyclohex-2-en-1-one, a new isophorone derivative. Single-crystal X-ray diffraction (SCXRD) was used to determine the crystal structure, which showed that the molecule crystallizes in a monoclinic system (space group P121/c1) with packing configurations and intermolecular interactions. To learn more about the non-covalent interactions influencing the crystal packing, Hirshfeld surface analysis was used. In order …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 2, 2025 · pp. 51–69 Read article
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Synthesis and Biological Screening of Some New3,5-Disubstituted-2-Isoxazolines
Abstract: Series of novel 3,5-disubstituted-2-isoxazolines have been synthesized via 1,3-dipolarcycloaddition reactions. All the synthesised compounds were confirmed by spectroscopic methods evaluated for their antimicrobial activity and were compared with the standard drugs. The compounds demonstrated potent to weak antimicrobial activity.Keywords: Isoxazolines, antimicrobial activity, chloramine-T
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 2, Issue 2, 2011 · pp. 8–15 Read article
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Isolation and Characterization of 1,6-Dihydroxy-3-Methoxy-8-Methyl Xanthones from Swertia purpurascens Wall – A High Altitude Himalayan Medicinal Herb
Abstract: Normal 0 false false false EN-US X-NONE X-NONE 1, 6-dihydroxy-3-methoxy- 8- methyl xanthones from Swertia purpurascens Wall. (Gentianaceae) has been isolated along with oleanolic acid. 1,6-dihydroxy-3-methoxy- 8- methyl xanthones for the first time has been reported from this plant source and identified by means of chemical as well as spectroscopic methods.Keywords: Swertia, 1, 6-dihydroxy-3-methoxy- 8- methyl xanthones, oleanolic acid, isolation.
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 3, Issue 1, 2012 · pp. 1–5 Read article
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Synthesis, Characterization and Biological Activity: Co(II), Ni(II), Cu(II) and Zn(II) Complexes of Schiff Bases Derived from 4-Cyanobenzaldehye and 4-Amino-5-Mercapto-3-Methyl/Ethyl-1,2,4-triazoles
Abstract: Co(II), Ni(II), Cu(II) and Zn(II) complexes of bidentate Schiff bases derived from the condensation of 4-amino-5-mercapto-3-methyl-1,2,4-triazole and 4-amino-3-ethyl-5-mercapto-1,2,4-triazole with 4-cyanobenzaldehyde have been synthesized. The synthesized Schiff bases and their metal complexes were then characterized by elemental analysis, spectroscopic methods (IR, NMR, electronic spectra), magnetic moment measurement and thermogravimetric techniques. The electronic spectra and magnetic moment studies suggest octahedral geometry for Co(II), Ni(II) and Zn(II) complexes and square planar geometry for …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 5, Issue 2, 2014 · pp. 27–36 Read article
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Design and Development of Self Microemulsyfying Drug Delivery System of Olmesartan Medoxomil
Abstract: Olmesartan Medoxomil is poorly water soluble drug. It comes into the BCS II drug. Hence oral bioavailability of Olmesartan Medoxomil is less (26%). The purpose of this study is to develop novel dosage form of the self-microemulsifying drug delivery systems (SMEDDS) for the Olmesartan Medoxomil for enhancing its solubility hence the oral bioavailability. Before the formulation of SMEDDS, solubility study was performed in different excipients and select excipients on basis …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 3, Issue 3, 2013 · pp. 1–14 Read article
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Friendly and Efficient Synthesis of Chalcone Derivatives under Solvent-Free Condition
Abstract: A series of various chalcone derivatives were synthesized using solvent free technique by grinding different substituted benzaldehyde, acetophenone and NaOH pellets at room temperature, and same reactions were carried out under solvent condition (50% EtOH). The reaction time needed to synthesize desired chalcones was 15–45 min; and 13 h stirring in the presence of solvent. All compounds were identified by comparison of their melting points with that of the substrates; …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 6, Issue 1, 2016 · pp. 17–24 Read article
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Isolation and Characterization of β -D-Glucan from Yeast and its In Vitro Biological Study
Abstract: In many microorganisms, fungi and algae, β-D-glucan can be found as cell wall polysaccharide. Various publications describe the strong positive influence of these glucans on the immune system comprising antibacterial, woundhealing and antitumor activities. Recently, it was found that β-D-glucan from the yeast Saccharomyces cervisiae also exhibit antioxidative capabilities. In the present study, the β-D-glucan was isolated from the cell wall of yeast and it is characterized by chromatographic, spectroscopic …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 2, Issue 1, 2012 · pp. 16–23 Read article
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Chemical Constituents from High Altitude Herbs of Kumaun Himalaya: Swertia Purpurascens Wall
Abstract: ABSTRACTA rare triterpenoid queretoric acid from Swertia purpurascens Wall. (Gentianaceae) has been isolated along with β-sitosterol-D-glycoside, oleanolic acid. Except oleanolic acid these two compounds for the first time have been reported from this plant source and identified by means of chemical as well as spectroscopic methods.Keywords: Swertia, queretoric acid, β-sitosterol-D-glycoside, oleanolic acid, isolation
Published in Research & Reviews : Journal of Herbal Science · Vol. 1, Issue 1, 2012 · pp. 24–30 Read article
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Design and Development of Self Microemulsyfying Drug Delivery System of Olmesartan Medoxomil Smita D Patel*, M R Patel, K R Patel
Abstract: Olmesartan Medoxomil is poorly water soluble drug. It comes into the BCS II drug. Hence oral bioavailability of Olmesartan Medoxomil is less (26%). The purpose of this study is to develop novel dosage form of the self-microemulsifying drug delivery systems (SMEDDS) for the Olmesartan Medoxomil for enhancing its solubility hence the oral bioavailability. Before the formulation of SMEDDS, solubility study was performed in different excipients and select excipients on basis …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 3, Issue 3, 2013 · pp. 1–15 Read article
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Analytical Method Development and Validation for Estimation of Brisoprolol Fumerate in Bulk and Pharmaceutical Dosage Form by UV Spectrometric Method
Abstract: The objective of the present work is to develop a new, rapid, simple, economical, precise, sensitive, linear and accurate, UV Spectrophotometric method has been developed. Phosphate buffer of pH 6.8 is used as solvent for the estimation of Brisoprolol Fumerate bulk and pharmaceutical formulation as per ICH guidelines. Spiked Brisoprolol Fumerate was checked over UV-visible extend for its wavelength of greatest absorbance. The wavelength of most extreme absorbance for Brisoprolol …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 1, 2022 · pp. 34–40 Read article
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SUBSTITUTED TRI-PEPTIDE DERIVATIVES SYNTHESIS, CHARACTERIZATION
Abstract: By using amino acid residues the peptides can be synthesized using either solid phase peptide synthesis or solution phase peptide synthesis. In this research article we preferred solution phase peptide synthesis because the formed intermediate unnecessary products can be easily isolated and purified. On through literature survey we found that the solution phase synthesis of tripeptides employing HATU/HOBt as coupling agent by using microwave irradiation[720 watts] has been mentioning in …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 10, Issue 1, 2023 · pp. 52–63 Read article
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Comprehensive Overview of Analytical Chemistry: Principles, Techniques, and Method Validation
Abstract: Analytical chemistry constitutes a vital discipline within the realm of scientific inquiry, facilitating the identification and measurement of components present in diverse substances and mixtures. This paper delineates the principles, methodologies, and applications of analytical chemistry, focusing on spectroscopy and chromatography techniques. Spectroscopy, including UV-Visible spectroscopy, elucidates molecular properties by analysing the absorption of electromagnetic radiation, while chromatography enables the separation of compound mixtures based on differential affinities to stationary …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 1, 2024 · pp. 14–21 Read article
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UV Method of Development and Validation of Olaparib
Abstract: An analytical method must be developed and validated in the discovery, development, and production of pharmaceuticals to ensure the identification, purity, potency, and performance of drug commodities. Quality control laboratories use official test protocols that emerge from the processes. A simple ultraviolet spectrophotometric approach was designed and validated using various characteristics, including linearity. Precision, reproducibility, accuracy, robustness, ruggedness, limit of detection, and limit of quantification are among the measuring criteria. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 20–27 Read article
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Hydrothermal synthesis of ZnS for efficient photodegradation of Malachite green
Abstract: In this work, ZnS nanoparticles were prepared by hydrothermal method. Various characterization techniques such as X-ray diffraction (XRD), UV-visible optical spectroscopy and FT-IR spectra were used to study the structural, composition and optical properties of synthesized nanoparticles. The XRD pattern showed that the prepared ZnS nanoparticles have a cubic zinc blende structure. The band gap is calculated from absorption spectra with the help of Taucplot and is found to be …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 10, Issue 1, 2020 · pp. 11–15 Read article
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FT-IR Analysis of Single Walled Carbon Nanotubes based PA12/PMMA Nanocomposites
Abstract: Development of new polymer composites for different applications is gaining interest. In this context, the author has synthesized novel blends and its nanocomposites consisting of Polyamide12 (PA12), Poly methyl methacrylate (PMMA), functionalized and non-functionalized carbon nanotubes by using melt extrusion, followed by injection molding technique. To understand molecular interaction among the blend components, these composites, namely PA12/PMMA blend and PA12/PMMA/SWCNT, SWCNT-OH, SWCNT-COOH nanocomposites are characterized by infrared spectroscopic (IR) methods. …
Published in Research & Reviews : Journal of Physics · Vol. 8, Issue 2, 2019 · pp. 75–82 Read article
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Electron beam irradiation studies of polyethylene maleic anhydride on their Chemical and Thermal properties.
Abstract: The electron beam (e-beam) irradiation effects on polyethylene maleic anhydride (MANPE) are investigated by spectroscopic and thermal methods. The MANPE irradiated with electron beam to a radiation dose of 30, 60 and 90 K Gy and the resultant changes in their chemical structure and thermal properties have been investigated by Electron spin resonance (ESR), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and scanning electron microscopy …
Published in Journal of Polymer & Composites · Vol. 6, Issue 2, 2018 · pp. 17–30 Read article
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Recent Advancements and Comprehensive Review on Hyphenated Techniques
Abstract: Hyphenated techniques represent a powerful class of analytical methods that combine two or more established techniques – typically a separation method with a spectroscopic detection technique – to achieve enhanced analytical performance. First introduced by Hirschfeld in 1980, the term “hyphenation” refers to the online coupling of such methods, enabling more precise, sensitive, and comprehensive analysis of complex samples. These techniques exploit the strengths of individual methods while overcoming their …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 37–50 Read article