Search
412 articles for “PKA/CREB pathway”
Nothing matched all of your words, so these match any of them.
-
Rheumatoid Arthritis and Stem Cell Therapies Perspectives for It
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by systemic inflammation, primarily affecting synovial joints, leading to joint destruction and systemic complications. The pathogenesis involves immune system dysregulation, autoantibody production, and enzymatic imbalances. Enzymes, including matrix metalloproteinases (MMPs), serine proteases, and kinases, play crucial roles in these processes. Their dysregulation contributes significantly to disease progression through the imbalance of pro-inflammatory cytokines, oxidative stress, and extracellular matrix (ECM) degradation. MMPs, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
-
Formulation and Evaluation of Herbal Anti-inflammatory oil using Tamarindus Indica oil, Vitex Negundo oil and Ipomoea batatas oil
Abstract: The formulation and evaluation of a herbal anti-inflammatory oil derived from the leaves of Tamarindus indica (Tamarind) Ipomoea batatas (Sweet potato) Vitex negundo (Nirgundi) aim to explore the therapeutic potential of these plants in managing pain and inflammation. Tamarind leaves are rich in flavonoids like quercetin, which primarily provide anti-inflammatory benefits by inhibiting pro-inflammatory cytokines, though their analgesic effects are moderate. Nirgundi leaves contain eugenol, known for its strong analgesic …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 01–06 Read article
-
Mechanisms of Crystal Growth: From Spiral Steps to Surface Adhesion
Abstract: Crystal growth is a complex interplay between thermodynamic stability and kinetic processes, influenced heavily by the conditions under which crystallization occurs—particularly the degree of supersaturation. This abstract outline three principal regimes of solution-grown crystal growth: defect-driven, two-dimensional, and adhesive growth. At low supersaturation, growth is facilitated at surface defects, such as screw dislocations, where energy barriers to attachment are minimized. This results in the formation of spiraling steps that propagate …
Published in International Journal of Crystalline Materials · Vol. 2, Issue 1, 2025 · pp. 46–31 Read article
-
Nanotechnology in Internet of Things: A Powerful Partnership Shaping the Future
Abstract: IOT holds potential to improve lives and revolutionize industries. However, its widespread adoption depends on addressing the growing energy consumption concerns. Nanotechnology provides a pathway to create a more energy-efficient IoT ecosystem by enabling the development of self-powered devices, low-power electronics, high-performance batteries, and advanced sensors. IoT is changing our daily lives and work by linking countless devices and producing vast amounts of data.. However, this explosive growth comes with …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 15, Issue 2, 2025 Read article
-
Comparison Analysis of Transformer Boosting and Induced Degeneration Topology Design of LNA for Millimeter Wave Frequency Range Using Polymeric Substrates
Abstract: In this study, a comparison between transformer boosting and source degeneration LNA topologies is conducted using two polymeric substrates—Polyimide (PI) and Liquid Crystal Polymer (LCP)—for millimeter-wave (mmWave) applications. With growing interest in flexible and high-frequency electronics, polymeric materials offer unique advantages such as low dielectric constants, mechanical flexibility, and thermal stability. The analysis explores gain, return loss, and noise figure performance while evaluating the influence of dielectric properties on the …
Published in International Journal of Electrical and Communication Engineering Technology · Vol. 3, Issue 2, 2025 · pp. 1–24 Read article
-
Comparison of Several Clinical Scoring Systems in Predicting the Outcome of Variceal Bleeding
Abstract: Background: Stratification of variceal bleeding patients into high-risk and low-risk group is very important to guide them through the suitable clinical pathway and to save the medical costs. We purposed to find out the best scoring system in the prediction of rebleeding and death after variceal bleeding by comparing four clinical scoring systems(clinical Rockall score, complete Rockall score, AIMS65 score, Child-Pugh score) which seemed to be applicable and simple. Method: …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 2, 2025 Read article
-
Development of 3D Printing Filaments from Industrial Waste Plastics
Abstract: The global plastic waste crisis has prompted innovative approaches to sustainable material reuse, particularly in additive manufacturing. Simultaneously, the accumulation of plastic waste presents significant environmental concerns. Recycling plastic into filament supports eco-friendly innovation and brings us closer to a circular economy where materials are reused instead of thrown away. This study investigates the development of 3D printing filaments from industrial waste plastics, including polypropylene (PP), acrylonitrile butadiene styrene (ABS), …
Published in International Journal of Energy and Thermal Applications · Vol. 3, Issue 1, 2025 · pp. 12–17 Read article
-
Crossroads of Ecology and Medicine: Evaluating Pollutant-Induced Risks to Biodiversity and Human Health
Abstract: Environmental pollution has emerged as a central challenge at the crossroads of ecology and human medicine. The rapid pace of industrialization, urbanization, and agricultural intensification has led to an unprecedented release of pollutants into the air, water, and soil—triggering cascading effects on ecosystems and human health. Pollutants such as particulate matter, heavy metals, pesticides, microplastics, endocrine-disrupting chemicals, and persistent organic pollutants not only degrade biodiversity but also exert multifaceted health …
Published in International Journal of Environmental Noise and Pollution Control · Vol. 3, Issue 1, 2025 · pp. 41–53 Read article
-
Impacts of Climate Change on Land Degradation: A Review of Mitigation
Abstract: Land degradation has emerged as one of the most pressing environmental challenges globally, significantly impacted by the multifaceted and escalating effects of climate change. The degradation of land, including soil erosion, nutrient depletion, deforestation, and desertification, directly threatens food security, biodiversity, and human livelihoods. As climate change leads to increasingly erratic weather patterns, including prolonged droughts, intense rainfall, and extreme temperatures, land degradation has become more pronounced and widespread, exacerbating …
Published in International Journal of Land · Vol. 2, Issue 1, 2025 · pp. 6–10 Read article
-
Polymer-Based Materials in Green and Sustainable Construction
Abstract: The escalating impacts of global warming, driven by greenhouse gas emissions, demand urgent action in the construction sector, which contributes over 40% of global CO₂ emissions. Smart buildings, designed to optimize energy use, water efficiency, and occupant comfort through automation and advanced materials, represent a transformative response to these challenges. The convergence of sustainability and urban development has spotlighted the need for green materials in smart building design. With buildings …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 42–48 Read article
-
The Role of Optimization and Probability in Shaping Artificial Intelligence
Abstract: This study discusses the basic roles of optimization algorithms and the theory of probability in the process of evolution and development of Artificial intelligence (AI). First, we introduce the role played by the next generation of leading-edge optimization algorithms developed since gradient descent to evolutionary strategies with respect to the learning of high-level AI models and how to enable them to learn to effectively explore high-dimensional parameter spaces. At the …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 2, 2025 · pp. 123–128 Read article
-
Innovative Polymer Membranes for Enhanced Gas Separation: Applications in Energy and Environmental Technologies
Abstract: Energy and environmental technology could benefit greatly from novel gas-separation membranes, especially those based on new polymers. This includes the design and characterization of new polymer membranes with enhanced selectivity and permeability for critical industrial gas separations like CO₂/CH₄ as well as CO₂/H₂. Using molecular design strategies, the membranes are addressed toward properties relevant for gas transport, which are important for applications that include carbon capture, natural gas purification, and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article
-
High Expectations, Low Outcomes: Exploring Coping Mechanisms and Psychological Adaptation
Abstract: This review paper explores the psychological impact of high expectations and low outcomes, focusing on coping mechanisms to manage the resulting emotional and mental challenges. The anticipation of a guaranteed future often elevates self-esteem and brings a state of emotional ecstasy. When individuals perceive the future in alignment with their personal terms and conditions, they experience heightened happiness and acceptance of life. This sense of assurance often influences risk-taking capacity, …
Published in International Journal of Trends in Humanities · Vol. 2, Issue 2, 2025 · pp. 31–38 Read article
-
Understanding the Impact of GMO on Hormones and Their Effect on Mood: A Review Paper
Abstract: The research evaluates how consuming genetically modified organisms affects endocrine functioning that can potentially lead to mood changes or disorders. This is a systematic review paper that analysed sixty publications before selecting thirty which were obtained from Sciencedirect, Frontiers, Springer, Oxfordacadamic, Cabidigitallibrary, Wileyonlinelibrary, Cambridgeuniversitypress, Scijournals, Mdpi, Metabolismjournal; while using Prisma Flow Diagram as the research tool; acknowledging that human hormonal health risks from GMO consumption remain largely unknown due to …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 14, Issue 3, 2025 Read article
-
Evaluating Delay Impacts: From Root Cause Analysis to Dispute Resolution
Abstract: Construction projects inherently involve complex coordination among multiple stakeholders, interdependent tasks, and unpredictable external challenges, which frequently cause schedule overruns and disputes. Traditional contractual mechanisms—such as extensions of time (EoT), liquidated damages, and force majeure clauses—serve to define responsibilities, allocate risk, and establish formal dispute pathways when delays arise. For example, EoT provisions protect contractors from penalties when delays are beyond their control, provided proper notice and evidence are submitted …
Published in Journal of Structural Engineering and Management · Vol. 12, Issue 3, 2025 · pp. 11–25 Read article
-
Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
-
Bio-Inspired Nanostructured Catalysts for CO2 Valorization: Green Chemistry Approaches in Polymer Nanocomposites for Sustainable Energy Solutions
Abstract: Artificial photosynthesis is a pioneering technology inspired by natural photosynthetic processes, offering a sustainable solution to address global energy crises and mitigate environmental impact. By harnessing solar energy, artificial photosynthesis aims to convert carbon dioxide (CO₂) and water into high-energy chemicals, such as methanol and hydrogen, while concurrently reducing harmful greenhouse gas emissions. This innovative process represents a transformative shift toward carbon-neutral or even carbon-negative energy production, helping reduce dependency …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 38–46 Read article
-
Intergenerational Trauma and Cultural Resilience: Exploring the Impact of Family Norms on Mental Health Disclosure
Abstract: This comprehensive review examines how intergenerational trauma and cultural resilience influence individuals' choices to disclose or conceal their mental health challenges in family contexts. This paper utilizes 50 peer-reviewed studies out of 80 in total from various cultural contexts, this paper explores how family norms, especially in collectivist cultures, impact the disclosure of mental health issues. This review paper uses a thematic analysis strategy, systematically integrating qualitative, quantitative, and mixed-method …
Published in International Journal of Behavioral Sciences · Vol. 2, Issue 2, 2025 · pp. 53–58 Read article
-
Chronic Obstructive Pulmonary Disease (COPD) in Younger Adults: Challenges and Considerations – A Review
Abstract: Chronic Obstructive Pulmonary Disease (COPD) phenomenon rapidly converting into chronic significant health issues for many young adults. A disease calculated for older age gives way to early-onset COPD, which creates new issues for diagnosing and treating the illness and even interacts with the quality of life. The article reviews the epidemiology, risk factors, pathophysiology, clinical presentation, and treatment considerations related to this set of conditions. From those risk factors, early-onset …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 08–19 Read article
-
Nutraceuticals Unveiled: Exploring the Science, Benefits, and Future of Functional Food
Abstract: The rapidly developing subject of nutraceuticals is critically examined in this review, with a focus on its scientific basis, proven health advantages, and possible future applications in the functional food industry. Key bioactive ingredients that contribute to the therapeutics effectiveness of functional foods, including flavonoids, polyphenols, carotenoids, probiotics, and essential fatty acids, have been identified and characterized as a result of recent developments in nutritional science. Both experimental and clinical …
Published in International Journal of Nutritions · Vol. 2, Issue 2, 2025 Read article